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Antigenic relationships of hantavirus strains analysed by monoclonal antibodies

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Summary

The antigenic relationships among 71 hantavirus strains, isolated from rodent species or humans in several geographic regions, were examined by immunofluorescence assay (IFA) using human patient sera and a panel of 22 monoclonal antibodies prepared against Hantaan, Seoul, and Puumala viruses. The study included virus strains, mainly from the former USSR, for which little or no serological data were available. Fifty-nine of the 71 isolates could be placed into five antigenic groups of hantaviruses, Hantaan (HTN), Puumala (PUU), Seoul (SEO), Prospect Hill (PH), Dobrava/Belgrade (DOB). Twelve isolates were found antigenically closely related to, but distinct from, HTN (2 strains), PUU (4 strains) and PH (6 strains), respectively. The antigenic characteristics of these 12 isolates suggested two supplementary antigenic subgroups of HTN, one of PUU, and two of PH. The two antigenic subgroups of HTN included strains isolated in the Far-East of Russia. The PUU subgroup included strains isolated in European Russia as well as strains isolated in Far-Eastern Russia. The PH group comprised two subgroups, both represented by strains isolated fromM. fortis in Far-Eastern Russia. The results showed that the PUU and PH antigenic groups are more complex than previously known and that PH-like virus strains isolated in Russia are antigenically more closely related to PUU virus when compared to prototype PH virus isolated in the USA.

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References

  1. Brummer-Korvenkontio M, Henttonen H, Vaheri A (1982) Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. Scand J Infect Dis [Suppl] 36: 88–91

    Google Scholar 

  2. CDC (1993) Hantavirus pulmonary syndrome — United States. CDC Update 42: 816–820

    Google Scholar 

  3. Chu YK, Rossi C, LeDuc JW, Lee HW, Schmaljohn CS, Dalrymple JM (1994) Serological relationships among viruses in theHantavirus genus, familyBunyaviridae. Virology 198: 196–204

    PubMed  Google Scholar 

  4. Dzagurova TK, Tkachenko EA, Petrov VA (1988) Effectiveness of tissue culture antigens for serodiagnosis of HFRS by IFA test. Vopr Virusol 1: 71–75 [in Russian]

    Google Scholar 

  5. Elliott RM (1990) Molecular biology of the Bunyaviridae. J Gen Virol 71: 501–522

    PubMed  Google Scholar 

  6. Hjelle B, Jenison S, Torrez-Martinez N, Yamada T, Nolte K, Zumwalt R, MacInnes K, Myers G (1994) A novel hantavirus associated with an outbreak of fatal respiratory disease in the southwestern United States: evolutionary relationships to known hantaviruses. J Virol 68: 592–506

    PubMed  Google Scholar 

  7. Lee HW, Lee PW, Johnson KM (1978) Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis 137: 298–308

    PubMed  Google Scholar 

  8. Lee HW, Baek LJ, Johnson KM (1982) Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J Infect Dis 146: 638–644

    PubMed  Google Scholar 

  9. Lee PW, Amyx HL, Gajdusek DC, Yanagihara RT, Goldgaber D, Gibbs CJ Jr (1982) New haemorrhagic fever with renal syndrome-related virus in indigenous wild rodents in the United States. Lancet ii: 1405

    Google Scholar 

  10. Lee PW, Gibbs CJ, Gajdusek DC, Yanagihara R (1985) Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests. J Clin Microbiol 22: 940–944

    PubMed  Google Scholar 

  11. Lundkvist Å, Niklasson B (1992) Bank vole monoclonal antibodies against Puumala virus envelope glycoproteins: identification of epitopes involved in neutralization. Arch Virol 126: 93–105

    PubMed  Google Scholar 

  12. Lundkvist Å, Niklasson B (1994) Haemorrhagic fever with renal syndrome and other hantavirus infections. Rev Med Virol 4: 177–184

    Google Scholar 

  13. Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ (1993) Genetic identification of a hantavirus associated with a outbreak of acute respiratory illness. Science 262: 914–917

    PubMed  Google Scholar 

  14. Plyusnin A, Vapalahti O, Lankinen H, Lehväslaiho, Apekina N, Myasnikov Y, Kallio-Kokko H, Henttonen H, Lundkvist Å, Brummer-Korvenkontio M, Gavrilovskaya, Vaheri A (1994) Tula virus: a newly detected hantavirus carried by European common voles. J Virol 68: 7833–7839

    PubMed  Google Scholar 

  15. Schmaljohn CS, Hasty SE, Dalrymple JM, LeDuc JW, Lee HW, von Bonsdorff C-H, Brummer-Korvenkontio M, Vaheri A, Tsai TF, Regnery HL, Goldgaber D, Lee PW (1985) Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome. Science 227: 1041–1044

    PubMed  Google Scholar 

  16. Sheshberadaran H, Niklasson B, Tkachenko EA (1988) Antigenic relationship between Hantaviruses analysed by immunoprecipitation. J Gen Virol 69: 2645–2651

    PubMed  Google Scholar 

  17. Sugiyama K, Morikawa S, Matsuura Y, Tkachenko EA, Morita C, Komatsu T, Akao Y, Kitamura T (1987) Four types of haemorrhagic fever with renal syndrome viruses identified by polyclonal and monoclonal antibodies. J Gen Virol 68: 979–987

    PubMed  Google Scholar 

  18. Tkachenko EA, Bashkiritsev VN, van der Groen G, Dzagurova TK, Ivanov AP, Ryltseva EV (1984) Isolation in Vero E6 cells of hantavirus fromClethrionomys glareolus captured in Bashkiria area of the USSR. Ann Soc Belg Med Trop 65: 121–135

    Google Scholar 

  19. Vapalahti O, Kallio-Kokko H, Salonen E-M, Brummer-Korvenkontio M, Vaheri A (1992) Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. J Gen Virol 73: 829–838

    PubMed  Google Scholar 

  20. Xiao S-Y, LeDuc JW, Chu YK, Schmaljohn CS (1994) Phylogenetic analysis of virus isolates in the genusHantaviruses, familyBunyaviridae. Virology 198: 295–217

    Google Scholar 

  21. Yamanishi K, Dantos F, Takahashi M, Yamanouchi T, Domae K, Takahashi Y, Tanishita O (1984) Antigenic differences between two viruses isolated in Japan and Korea, that cause HFRS. J Virol 52: 231–237

    PubMed  Google Scholar 

  22. Yan DY, Xie YJ, Zhang CA, McCormick JB, Sanchez A (1986) New isolates of HFRS viruses in Sichuan, China and characterisation of antigenic differences by monoclonal antibodies. Lancet i: 203

    Google Scholar 

  23. Yanagihara R, Gajdusek DC (1988) Hemorrhagic fever with renal syndrome: a historical perspective and review of recent advances. In: Gear JHS (ed) Handbook on viral and rickettsial hemorrhagic fevers. CRC Press, Boca Raton, pp 151–188

    Google Scholar 

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Authors and Affiliations

  1. Institute of Poliomyelitis and Viral Encephalitides, Academy of Medical Science, Moscow

    T. Dzagurova, E. Tkachenko & A. Dekonenko

  2. Institute of Epidemiology and Microbiology, Academy of Medical Science, Vladivostok

    R. Slonova

  3. Anti-plague Station, Khabarovsk, Russia

    L. Ivanov

  4. Anti-plague Station, Georgia

    E. Ivanidze

  5. Anti-plague Station, Simferopol, Ukraine

    S. Markeshin

  6. Swedish Institute for Infectious Disease Control, Stockholm

    B. Niklasson & Å. Lundkvist

  7. National Defense Research Establishment, Umeå

    B. Niklasson

  8. Karolinska Institute, Stockholm, Sweden

    Å. Lundkvist

Authors
  1. T. Dzagurova
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  2. E. Tkachenko
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  3. R. Slonova
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  4. L. Ivanov
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  5. E. Ivanidze
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  6. S. Markeshin
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  7. A. Dekonenko
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  8. B. Niklasson
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  9. Å. Lundkvist
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Dzagurova, T., Tkachenko, E., Slonova, R. et al. Antigenic relationships of hantavirus strains analysed by monoclonal antibodies. Archives of Virology 140, 1763–1773 (1995). https://doi.org/10.1007/BF01384340

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  • DOI: https://doi.org/10.1007/BF01384340

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