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Development of hamster circadian rhythms: Role of the maternal suprachiasmatic nucleus

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Summary

During development, the circadian rhythms of rodents become entrained to rhythmicity of the mother. Rhythms in behavior and in neuroendocrine function are regulated by a circadian pacemaker thought to be located within the suprachiasmatic nucleus (SCN) of the hypothalamus. Evidence indicates that this pacemaker begins to function and to be entrained by maternal rhythms before birth. Although the maternal rhythms which mediate prenatal entrainment of the fetal circadian pacemaker have not been identified, it is likely that they are regulated by the maternal SCN.

The role of the maternal SCN in entrainment of the offspring was examined in Syrian hamsters (Mesocricetus auratus) by measuring the activity/rest rhythms of pups. Using the synchrony among the rhythms of pups within a litter as an indication that the pups had been entrained, the effect on entrainment of ablating the maternal SCN was determined. Lesions of the maternal SCN which were performed early in gestation (day 7) and which destroyed at least 75% of the SCN were found to disrupt the normal within litter synchrony among pups, indicating interference with the normal mechanism of entrainment.

The effect of lesions on day 7 of gestation could mean that the maternal SCN is important for entrainment of the pups before birth, after birth, or during both of these times. To determine if the maternal SCN is specifically important for prenatal entrainment, lesions were performed two days before birth on day 14 of gestation. Lesions of the maternal SCN on day 14 were not as disruptive as were lesions on day 7. This suggests that the maternal SCN is important between days 7 and 14 of gestation and that the synchrony normally observed at weaning is already established, in part, on or before day 14 of gestation. This further suggests that an entrainable circadian pacemaker is present in the fetus only two weeks after fertilization.

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Abbreviations

SCN :

suprachiasmatic nucleus

L:D :

light:dark

LL :

constant light

r :

mean vector length

2DG :

2-deoxyglucose

NAT :

N-acetyltransferase

References

  • Altman J, Bayer SA (1978) Development of the diencephalon of the rat: I. Autoradiographic study of the time of origin and settling patterns of neurons of the hypothalamus. J Comp Neurol 183:945–972

    Google Scholar 

  • Batschelet E (1972) Recent statistical methods for orientation data. In: Galler SR (ed) Animal orientation and navigation. US Government Printing Office, Washington, DC, pp 61–91

    Google Scholar 

  • Crossland WJ, Uchwat CJ (1983) Neurogenesis in the central visual pathways of the golden hamster. Dev Brain Res 5:99–103

    Google Scholar 

  • Davis FC, Gorski RA (1983) Entrainment of circadian rhythms in utero: role of the maternal suprachiasmatic nucleus. Soc Neurosci Abstr 8:625

    Google Scholar 

  • Davis FC, Gorski RA (1985) Development of hamster circadian rhythms I. Within-litter synchrony of mother and pup activity rhythms at weaning. Biol Reprod 33:353–362

    Google Scholar 

  • Davis FC, Gorski RA (1986) Development of hamster circadian rhythms II. Prenatal entrainment of the pacemaker. J Biol Rhythms 1:77–89

    Google Scholar 

  • Davis FC, Menaker M (1981) Development of the mouse circadian pacemaker: Independence from environmental cycles. J Comp Physiol 143:527–539

    Google Scholar 

  • Deguchi T (1975) Ontogenesis of a biological clock for serotonin: acetyl coenzyme A N-acetyltransferase in pineal gland of rat. Proc Natl Acad Sci USA 72:2814–2818

    Google Scholar 

  • Earnest DJ, Sladek CD (1986) Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro. Brain Res 382:129–133

    Google Scholar 

  • Green DJ, Gillette R (1982) Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice. Brain Res 245:198–200

    Google Scholar 

  • Hiroshige T, Honma K-I, Watanabe K (1982a) Possible Zeitebers for external entrainment of the circadian rhythm of plasma corticosterone in blind infantile rats. J Physiol (Lond) 325:507–519

    Google Scholar 

  • Hiroshige T, Honma K-I, Watanabe K (1982b) Prenatal onset and maternal modifications of the circadian rhythm of plasma corticosterone in blind infantile rats. J Physiol (Lond) 325:521–532

    Google Scholar 

  • Honma S, Honma K, Shirakawa T, Hiroshige T (1984a) Effects of elimination of maternal circadian rhythms during pregnancy on the postnatal development of circadian corticosterone rhythm in blinded infantile rats. Endocrinology 114:44–50

    Google Scholar 

  • Honma S, Honma K, Shirakawa T, Hiroshige T (1984b) Maternal phase setting of fetal circadian oscillation underlying the plasma corticosterone rhythm in rats. Endocrinology 114:1791–1796

    Google Scholar 

  • Inouye ST, Kawamura H (1982) Characteristics of a circadian pacemaker in the suprachiasmatic nucleus. J Comp Physiol 146:153–160

    Google Scholar 

  • Moore RY (1983) Organization and function of a central nervous system circadian oscillator: the suprachiasmatic hypothalamic nucleus. Fed Proc 42:2783–2789

    Google Scholar 

  • Moore RY, Lenn NJ (1972) A retinohypothalamic projection in the rat. J Comp Neurol 146:1–14

    Google Scholar 

  • Moore RY, Klein DC (1974) Visual pathways and the central neural control of a circadian rhythm in pineal N-acetyltransferase activity. Brain Res 71:17–33

    Google Scholar 

  • Newman GC, Hospod FE (1986) Rhythm of 2-deoxyglucose uptake in vitro. Brain Res 381:345–350

    Google Scholar 

  • Reppert SM, Schwartz WJ (1984) The suprachiasmatic nuclei of the fetal rat: characterization of a functional circadian clock using C-labeled deoxyglucose. J Neurosci 4:1677–1682

    Google Scholar 

  • Reppert SM, Schwartz WJ (1986a) Maternal suprachiasmatic nuclei are necessary for maternal coordination of the developing circadian system. J Neurosci 6:2724–2729

    Google Scholar 

  • Reppert SM, Schwartz WJ (1986b) Maternal endocrine extirpations do not abolish maternal coordination of the fetal circadian clock. Endocrinology 119:1763–1767

    Google Scholar 

  • Reppert SM, Coleman RJ, Heath HW, Swedlow JR (1984) Pineal N-acetyltransferase activity in 10-day-old rats: a paradigm for studying developing circadian system. Endocrinology 115:918–925

    Google Scholar 

  • Rusak B, Zucker I (1979) Neural regulation of circadian rhythms. Physiol Rev 59:449–526

    Google Scholar 

  • Schwartz WT, Davidson LC, Smith CB (1980) In vivo metabolic activity of a putative circadian oscillator, the rat suprachiasmatic nucleus J Comp Neurol 189:157–167

    Google Scholar 

  • Takahaski K, Murakami N, Hayafugi C, Sasaki Y (1984) Further evidence that circadian rhythm of blinded rat pups is entrained by the nursing dam. Am J Physiol 246:R359-R363

    Google Scholar 

  • Viswanathan N, Chandrashekaran MK (1985) Cycles of presence and absence of mother mouse entrain the circadian clock of pups. Nature 317:530–531

    Google Scholar 

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Davis, F.C., Gorski, R.A. Development of hamster circadian rhythms: Role of the maternal suprachiasmatic nucleus. J. Comp. Physiol. 162, 601–610 (1988). https://doi.org/10.1007/BF01342635

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  • DOI: https://doi.org/10.1007/BF01342635

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