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Influenza A virus replication is inhibited by tumor necrosis factor-α in vitro

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Summary

Treatment of Madin-Darby canine kidney (MDCK) cells with ≥ 10 ng/ml of recombinant murine tumor necrosis factor-α (rm TNF-α) prior to inoculation with influenza A/PR/8/34, (H1N1), resulted in decreased production of infectious virus as determined by plaque assay, inhibition of viral protein synthesis and a reduction in cytopathic effect. The inhibition of viral replication in vitro suggests a role for TNF-α in the host's defense against influenza A virus infections.

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  1. H. Van Campen

    Present address: Department of Veterinary Sciences, University of Wyoming, Wyoming, USA

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  1. Department of Veterinary Science, The Pennsylvania State University, Pennsylvania, USA

    H. Van Campen

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  1. H. Van Campen
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Van Campen, H. Influenza A virus replication is inhibited by tumor necrosis factor-α in vitro. Archives of Virology 136, 439–446 (1994). https://doi.org/10.1007/BF01321073

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  • DOI: https://doi.org/10.1007/BF01321073

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