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Tumor necrosis factor receptor genes,TNFR1 andTNFR2, on human chromosomes 12 and 1

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Somatic Cell and Molecular Genetics

Abstract

Tumor necrosis factor, TNF, is a 17-kDa protein secreted by macrophages and classified as a cytokine. TNF binds to high-affinity receptors on the cell surface and is involved in a wide variety of biological responses. There are at least two types of receptors, tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2). The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 1 12 (12pter-cen) and (1pter-p32), respectively, by Southern blot analysis of human × Chinese hamster somatic cell hybrid panels. Recently, the corresponding genes in the mouse have been mapped to chromosomes 4 and 6 in regions that are conserved on human chromosomes 1 and 12.

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Authors and Affiliations

  1. Department of Genetics, Stanford University School of Medicine, 94305, Stanford, California

    A. Milatovich & U. Francke

  2. Howard Hughes Medical Institute, Stanford University School of Medicine, 94305, Stanford, California

    U. Francke

  3. Institute of Cancer and Developmental Biology, Syntex Research, 94304, Palo Alto, California

    K. Song & R. A. Heller

Authors
  1. A. Milatovich
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  2. K. Song
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  3. R. A. Heller
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  4. U. Francke
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Milatovich, A., Song, K., Heller, R.A. et al. Tumor necrosis factor receptor genes,TNFR1 andTNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet 17, 519–523 (1991). https://doi.org/10.1007/BF01233176

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  • DOI: https://doi.org/10.1007/BF01233176

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