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Cytokines and bone marrow transplantation

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Abstract

This article summarizes the various current uses of cytokines, and bone marrow and peripheral blood stem cell transplantation for cancer treatment. Interferons, interleukin-2 and hematopoietic growth factors are extensively used for the treatment of hematopoietic as well as nonhematopoietic malignancies, either as the main therapeutic agents or as an adjuvant. Research on gene therapy using cytokines is in progress. Stem cell transplantation is also discussed in the context of gene therapy of cancer. Gene therapy is expected to become a future modality in cancer treatment.

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References

  • Ackerstein A, Kedar E, Slavin S (1991) Use of recombinant human interleukin-2 in conjunction with syngeneic bone marrow transplantation in mice as a model for control of minimal residual disease in malignant hematologic disorders. Blood 78:1212–1215

    PubMed  Google Scholar 

  • Andrews RG, Bensinger WI, Kniter GH, Bartelmez SH, Longin K, Bernstein ID, Appelbaum FR, Zsebo KM (1992) The ligand for c-kit, stem cell factor (SCF), stimulates the circulation of cells that engraft lethally irradiated baboons. Blood 80:2715–2720

    PubMed  Google Scholar 

  • Andrews RG, Briddell RA, Knitter GH, Rowley SD, Appelbaum FR, Mc Piece IK (1995) Rapid engraftment by peripheral blood progenitor cells mobilized by recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in nonhuman primate. Blood 85:15–20

    PubMed  Google Scholar 

  • Antman KS, Griffin JD, Elias A, Socinski MA, Ryan L, Lannistra SA, Oette D, Whitley M, Frei E, Schnipper LE (1988) Effect of human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 319:593–598

    PubMed  Google Scholar 

  • Asano S, Okano A, Ozawa K, Nakahata T, Ishibashi T, Koike K, Kimura H, Tanioka Y, Shibuya A, Hirano T, Kishimoto T, Takaku F, Akiyama Y (1990) In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets. Blood 75:1602–1605

    PubMed  Google Scholar 

  • Asano S, Masaoka T, Takaku F (1991) Beneficial effect of recombinant human glycosylated granulocyte colony-stimulating factor in marrow transplanted patients: results of multicenter phase II–III studies. Transplant Proc 23:1701–1703

    PubMed  Google Scholar 

  • Bartley TD, Bogenherger J, Hunt P, Li PS, Lu HS, Manin F, Chang MS, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu RY, Parker VP, Sugs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, Mc Ninch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Masu R, Celander L, Trollinger D, Sieu L, Padilla D, Trail G, Flliot G, Izumi R, Coney T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MCT, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA (1994) Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor. Mpl. Cell 77:1117–1124

    Google Scholar 

  • Beatty PG (1995) Bone marrow transplantation for the treatment of hematologic diseases, status in 1994. Exp Hematol 23:277–288

    PubMed  Google Scholar 

  • Berck JS (1992) Intraperitoneal immunotherapy for ovarian cancer with alpha interferon. Eur J Cancer 20A:719–721

    Google Scholar 

  • Brandt SJ, Peters WP, Atwater SK, Kurtzberg J, Borowitz MJ, Jones RB, Shpall EJ, Bast RC Jr, Gilbert CF, Oette DH (1988) Effect of recombinant human granulocyte-macrophage colony stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. N Engl J Med 318:869–876

    PubMed  Google Scholar 

  • Brandt J, Briddell RA, Srour EF, Leemhuis TB, Hoffman R (1992) Role of c-kit ligand in the expansion of human hematopoietic progenitor cells. Blood 79:634–641

    PubMed  Google Scholar 

  • Brenner MK, Rill DR, Holladay MS, Heslop H, Moen RC, Buschle M, Krance RA, Santana VM, Anderson WF (1993a) Gene marking to determine whether autologous marrow infusion restores long-term haematopoiesis in cancer patients. Lancet 342: 1134–1137

    PubMed  Google Scholar 

  • Brenner MK, Rill DR, Moen RC, Krance RA, Mirroj Jr, Anderson WF, Ihle JN (1993b) Gene-marking to trace origin of relapse after antologous bone-marrow transplantation. Lancet 341: 85–86

    PubMed  Google Scholar 

  • Bronchud MM, Howell A, Crowther D, Hopwood P, Souza LM, Dexter TM (1989) The use of granulocyte colony-stimulating factor to increase the intensity of treatment with doxorubicin in patients with advanced breast and ovarian cancer. Br J Cancer 60:121–125

    PubMed  Google Scholar 

  • Brugger W, Mocklin W, Heimfeld S, Bereuson RJ, Mertelsmann R, Kanz L (1993) Ex vivo expansion of enriched peripheral blood CD 34 progenitor cells by stem cell factor, interleukin 1 (IL-1), IL-6, IL-3, interferon-gamma, and erythropoietin. Blood 81:661–669

    PubMed  Google Scholar 

  • Brugger W, Bross KJ, Glatt M, Weber F, Mertelsmann R, Kanz L (1994) Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 83:636–640

    PubMed  Google Scholar 

  • Butturini A, Keating A, Goldman J, Gale RP (1990) Autotransplants in chronic myelogenous leukemia: strategies and results. Lancet 335:1255–1258

    PubMed  Google Scholar 

  • Charak BS, Chondhary GD, Tefft M, Mazumder A (1992) Interleukin-2 in bone marrow transplantation: preclinical studies. Bone Marrow Transplant 10:103–111

    PubMed  Google Scholar 

  • Clift RA, Appelbaum FR, Thomas ED (1993) Treatment of chronic myelogenous leukemia by marrow transplantation. Blood 82:1954–1956

    PubMed  Google Scholar 

  • Dimopoulos MA, Hester J, Huh Y, Champlin R, Alexanian R (1994) Intensive chemotherapy with blood progenitor transplantation for primary resistant multiple myeloma. Br J Hematol 87:730–734

    Google Scholar 

  • Dranoff G, Jaffe E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC. (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci USA 90:3539–3543

    PubMed  Google Scholar 

  • Dreger P, Suttorp M, Haferlach T, Hoffler H, Schmitz N, Schroyens W (1993) Allogeneic granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for treatment of engraftment failure after bone marrow transplantation. Blood 81:1404–1407

    Google Scholar 

  • Dreger P, Viehmann K, Steinmann J, Eckstein V, Muller-Ruckholtz W, Loffler H, Schmitz N (1995) G-CSF mobilized peripheral blood progenitor cells for allogeneic transplantation, comparison of T cell depletion strategies using different CD34+ selection systems on CAMPATH-1. Exp Hematol 23:147–154

    PubMed  Google Scholar 

  • Dunlop DJ, Wright EG, Lorimore S, Graham GJ, Holyoake T, Kerr DJ, Wolpe SD, Pragnell IB (1992) Demonstration of stem cell inhibition and myeloprotective effect of SCI/rhMIPI in vivo. Blood 79:2221–2225

    PubMed  Google Scholar 

  • Eddy DM (1992) High-dose chemotherapy with autologous bone marrow transplantation for the treatment of metastatic breast cancer. J Clin Oncol 5:327–332

    Google Scholar 

  • Flaherty L, Redman B, Chabot G, Martino S, Valdivieso M, Bradley E (1988) Combination of dacarbazine and interleukin-2 in metastatic malignant melanoma (abstract). Proc Am Soc Clin Oncol 7:254

    Google Scholar 

  • Gabrilove JL, Jakubowski A, Scher H, Sternberg C, Wong G, Grous J, Yogoda A, Faui K, Moore MAS, Clarkson B, Oetigen HF, Alton K, Welte K, Souza LM (1988) Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 318:1414–1422

    PubMed  Google Scholar 

  • Gahrton G, Tura S, Ljungman P, Belanger C, Brandt L, Cavo M, Facon T, Granena A, Gore M, Gratwohl A, Lowenberg B, Nikoskelainen J, Reiffers JJ, Samson D, Verdonck L, Volin L, for the European Group for Bone Marrow Transplantation (1991) Allogeneic bone marrow transplantation in multiple myeloma. N Engl J Med 325:1267–1273

    PubMed  Google Scholar 

  • Gorin NC, Labopin M, Meloni G, Korbling M, Carella A, merve P, Burnett A, Rizzoli V, Alessandrino EP, Bjorkstrand B, Ferrnat A, Lowenberg B, Coser P, Simonsson B, Helbig W, Brunet MS, Verdonck LF, Iriondo A, Polli E, Clombat P, Franklin IM, Sonillet G, Willemze R (1991) Autologous bone marrow transplantation for acute myeloblastic leukemia in Europe: further evidence of the role of marrow purging by mafosfamide. Leukemia 5:876–904

    Google Scholar 

  • Gribben JG, Freedman AS, Newberg D, Roy DC, Blake KW, Woo SD, Grossbard ML, Rabinowe SN, Coral F, Freedman GJ, Ritz J, Nadler LM (1991) Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. N Engl J Med 325:1525–1533

    PubMed  Google Scholar 

  • Haas R, Mo AD, Bredthauer U, Cayeux S, Egerer G, Knauf W, Hunstein W (1990) Successful autologous transplantation of blood stem cells mobilized with recombinant human GM-CSF. Exp Hematol 18:94–99

    PubMed  Google Scholar 

  • Haylock DN, To LB, Dowse TL, Juttner CA, Simons PJ (1992) Ex vivo expansion and maturation of peripheral blood CD34 cells into the myeloid lineage. Blood 180:1405–1412

    Google Scholar 

  • Kernan NA, Bartsch G, Ash RC, Beatty PG, Champlin R, Filipovich A, Gajewski J, Hansen JA, Henslee-Downey J, Mc Culloch J, Mc Glave P, Perkins HA, Phillips GL, Sanders J, Stroncek D, Thomas ED, Blume KG (1993) Analysis of 462 transplantations from unrelated donors facilitated by the national marrow donor program. N Engl J Med 328:593–602

    PubMed  Google Scholar 

  • Kerseys JH, Weisdorf D, Nesbort ME, LeBian TW, Woods WG, McClave PB, Kim T, Vallera DA, Goldman AI, Bostrom B, Hurd D, Ramsay NKC (1987) Comparison of autologous and allogeneic bone marrow transplantation for treatment of high-risk refractory acute lymphoblastic leukemia. N Engl J Med 317:461–473

    PubMed  Google Scholar 

  • Kirchner H, Korfer A, Palmer PA, Evers P, Riese WD, Knuver-Hopf J, Madman M, Goldman U, Franks CR, Poliwoda M, Atzpodien J (1990) Subcutaneous interleukin-2 and interferon-α 2b in patients with metastatic renal cell cancer: the German outpatients experience. Mol Biother 2:145–154

    PubMed  Google Scholar 

  • Kolb HJ, Mittermuller J, Clemm C, Holler E, Ledderose G, Brehm G, Heim M, Willmans W (1990) Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 76:2462

    PubMed  Google Scholar 

  • Lissoni P, Marni S, Ardizzoia A, Paolorossi F, Tisi E, Crispino S, Tancini G (1992) Imtracavitary administration of interleukin-2 as palliative therapy for neoplastic effusions. Tumori 78:118–120

    PubMed  Google Scholar 

  • Lok S, Kaushansky K, Holly RD, Kuijper JL, Lafton-Day CE, Oort PJ, Grant FJ, Heipel MD, Kurkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn JW, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC (1994) Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565–568

    PubMed  Google Scholar 

  • Ludwig M, Fritz E, Kotzmann H, Hocker P, Gisslinger H, Barnas U (1990) Erythropoietin treatment of anemia associated with multiple myeloma. N Engl J Med 322:1693–1699

    PubMed  Google Scholar 

  • Mandelli F, Avvisati G, Amadori S, Boccadoro M, Gernone A, Lauta VM, Marmont F, Petrucci MT, Tribalto M, Vegna ML, Dammacco F, Pileri A (1990) Maintenance treatment with recombinant interferon alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy. N Engl J Med 322:1430–1434

    PubMed  Google Scholar 

  • Masuzawa M, Higashi K, Nishioka K, Nishiyama S (1988) Successful immunotherapy for malignant hemangioendothelioma using recombinant interleukin-2 (in Japanese). Jpn J Dermatol 98: 367–369

    Google Scholar 

  • Mc Glae PB, Arthur D, Miller WJ, Lasky L, Kersey J (1990) Autologous transplantation for CML using marrow treated ex vivo with recombinant human interferon gamma. Bone Marrow Transplant 6:115–120

    PubMed  Google Scholar 

  • Miller CB, Jones RJ, Piantadosi S, Abeloff MD, Spivak JL (1990) Decreased erythropoietin response in patients with the anemia of cancer. N Engl J Med 322:1684–1692

    Google Scholar 

  • Mitchell MS, Kempt RA, Harel W, Shau H, Boswell WD, Lind S, Bradley EC (1988) Effectiveness and tolerability of low-dose cyclophosphamide and low-dose intravenous interleukin-2 in disseminated melanoma. J Clin Oncol 6:409–424

    PubMed  Google Scholar 

  • Miyazaki H, Kato T, Ogami K, Iwamatsu A, Shimada Y, Souma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kawamura K, Sudo T (1994) Isolation and cloning of a novel human thrombopoietic factor. Exp Hematol 22:838

    Google Scholar 

  • Montuoro A, DeRosa L, DeBlasio A, Pacilli L, Petti N, De Laurenzi A (1990) Alpha-2a-interferon/melphalan/prednisone versus melphalan/prednisone in previously untreated patients with multiple myeloma. Br J Haematol 76:365–368

    PubMed  Google Scholar 

  • Morstyn G, Campbell L, Souza LM, Alton NK, Keech J, Green M, Sheridan W, Metcalf D (1988) Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet I:667–672

    Google Scholar 

  • Motoyoshi K, Yoshida K, Hatake K, Saito M, Miura Y, Yanai N, Yamada M, Kawashima T, Wong GG, Temple PA, Leary AC, Witek-Giamotti JS, Fujisawa M, Yuo A, Okabe T, Takaku F (1989) Recombinant and native human urinary colony-stimulating factor directly augments granulocyte and granulocyte-macrophage colony-stimulating factor production of human peripheral blood monocytes. Exp Hematol 17:68–71

    PubMed  Google Scholar 

  • Neumaniatis J, Singer JW, Buckner D, Hill R, Storb R, Thomas ED, Appelbaum FU (1988) Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies. Blood 72:834–836

    PubMed  Google Scholar 

  • Nimer SD, Giorgi G, Gajewski N, Ku N, Schiller GJ, Lee K, Territo M, Ho W, Feig S, Selch M, Isacescu V, Reichert TA, Champlin RE (1994) Selective depletion of CD8+ cells for prevention of graft-versus host disease after bone marrow transplantation: A randomized controlled trial. Transplantation 57:82–87

    PubMed  Google Scholar 

  • Oster W, Mertelsmann R (1990) Erythropoietin for the treatment patients with anemia of malignancy. In: Mertelsmann R, Hermann F (eds) Hematopoietic growth factors in clinical applications. Dekker, New York, pp 141–148

    Google Scholar 

  • Oster W, Herrmann F, Gamm H, Zeile G, Lindermann A, Muller G, Brune T, Kaemer HP, Mertelsmann R (1990) Erythropoietin for the treatment of anemia of malignancy associated with neoplastic bone marrow infiltration. J Clin Oncol 8:956–962

    PubMed  Google Scholar 

  • Pichert G, Alyea EP, Soiffer RJ, Yoy DC, Ritz J (1994) Persisteance of myeloid progenitor cells expressing BCR-ABL mRNA after allogeneic bone marrow transplantation for chronic myelogenous leukemia. Blood 84:2109–2114

    PubMed  Google Scholar 

  • Pierelli L, Iacone A, Quaglietta AM, Nicolucci A, Menichella G, Panici PB, D'Antonio D, De Laurenzi A, De Rosa L, Fioritoni G, Indovina A, Leone G, Majolino I, Montuoro A, Scime R, Torlontano G (1994) Hematopoietic reconstitution after autologous blood stem cell transplantation in patients with malignancies: a multicenter retrospective study. Br J Haematol 86:70–75

    PubMed  Google Scholar 

  • Quesda JR, Reuken J, Manning JT, Hersh EM, Gutterman JR (1984) Alpha interferon for induction of remission in hairy cell leukemia. N Engl J Med 310:15–18

    PubMed  Google Scholar 

  • Rastum YM (1991) Rational basis for the metabolic modulation of 5-fluorouracil by leucovorin and interferon alfa. Br J Haematol 19 [Suppl]:52–55

    Google Scholar 

  • Recombinant Human Interferon Gamma (S-6810) Research Group on Renal Cell Carcinoma (1987) Phase II study of recombinant human interferon gamma (S-6810) on renal cell carcinoma: summary of two collaborative studies. Cancer 60:929–933

    Google Scholar 

  • Rosenberg SA, Lotze MT, Mull LM, Lettman A, Chang AE, Etinghausen SE, Matory YL, Skibber JM, Shiloni E, Vetto JT, Seipp CA, Simpson C, Reichert C (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313:1485–1492

    PubMed  Google Scholar 

  • Rosenberg SA, Lotze MT, Muul LM, Chang AE, Avis FP, Leitman S, Linehan WM, Rosenberg CN, Lee RE, Rubin JT, Seip CA, Simpson CG, White DE (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 316:889–897

    PubMed  Google Scholar 

  • Rosenberg SA, Packard BS, Aebersold PM, Solomon D, Topalian SL, Toy ST, Simon P, Lotze MT, Yang JC, Seipp CA, Simpson C, Carter C, Bock S, Schwartzentruber D, Wei JP, White DE (1988) Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. N Engl J Med 319:1676–1680

    PubMed  Google Scholar 

  • Rosenberg SA, Lotze MT, Yang JC, Linehan WM, Seipp C, Calabro S, Karp SE, Sherry RM, Steinberg S, White DE (1989) Combination therapy with interleukin-2 and alpha-interferon for the treatment of patients with advanced cancer. J Clin Oncol 7:145–154

    Google Scholar 

  • Rowley SD, Miller CB, Piantadosi S, Davis JM, Santos GW, Jones RJ (1991) Phase I study of combination drug purging for autologous bone marrow transplantation. J Clin Oncol 19: 2210–2215

    Google Scholar 

  • Schmidt-Wolf IGH, Dejbakhsh-Jones S, Ginzton N, Greenberg P, Strober S (1992) T cell subsets and suppressor cells in human bone marrow. Blood 80:3242–3250

    PubMed  Google Scholar 

  • Schulz G, Frisch J, Greifenbergy B, Nicolay U, Oster W (1991) New therapeutic modalities for the clinical use of rhGM-CSF in patients with malignancies. Am J Clin Oncol 14 [Suppl 1]: 19–26

    Google Scholar 

  • Sheridan WP, Begley CG, Jutter CA, Szer J, To LB, Maher D, McGrath KM, Morstyn G, Fox RM (1992) Effect of peripheral-blood progenitor cells mobilized by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy. Lancet 399:640–644

    Google Scholar 

  • Shpall EJ, Jones RB, Bearman S (1994) High-dose therapy with autologous bone marrow transplantation for the treatment of solid tumors. Curr Opin Oncol 6:135–138

    PubMed  Google Scholar 

  • Smaley RV, Anderson JW, Hawking MJ, Bhide V, O'Connell MJ, Oken MM, Borden EC (1992) Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma. N Engl J Med 327:1336–1341

    PubMed  Google Scholar 

  • Smith JW I, Longs DL, Urba WJ, Clark JW, Watson T, Beveridge J, Colon KC, Sznol M, Creekmore SP, Alvord WG, Lawrence JB, Steis R (1971) Prolonged, continuous treatment of hairy cell leukemia patients with recombinant interferon-α2a. Blood 78:1664–1671

    Google Scholar 

  • Smith JW, Longo D, Alvord W, Janik J, Shanfran W, Gause B, Curti B, Sznol M, Steis R, Miller L, Fenton R, Creekmore S, Holmlund J, Feim S, Shimize M, Oppenheim J, Hursey J, Houck M, Rubi WJ (1992) Thrombopoietic effects of IL-1 alpha in combination with high dose carboplatin. Proc Am Soc Clin Oncol 11:820a

    Google Scholar 

  • Snyder DS, Wu Y, Wang JL, Rossi JJ, Swiderski P, Kaplem BE, Forman SJ (1993) Ribozyme-mediated inhibition ofbcr-abl gene expression in a Philadelphia chromosome-positive cell line. Blood 82:600–605

    PubMed  Google Scholar 

  • Stahl CP, Winton EF, Monroe MC, Haff E, Holman RC, Myers L, Liehl E, Evatt BL (1992) Differential effect of sequential, simultaneous and single agent interleukin-3 and granulocyte-macrophage colony-stimulating factor on megakaryocyte maturation and platelet response in primates. Blood 80:2479–2485

    PubMed  Google Scholar 

  • Suavage FJ de, Hass, PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Solberg A Jr, Goeddel DV, Eaton DL (1994) Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533–536

    PubMed  Google Scholar 

  • Szczlik C, Skorski T, Nicolaides NC, Manzella L, Malaguanera L. Venturellli D, Gewirtz AM, Calabretta B (1991) Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligonucleotides. Science 253:562–565

    PubMed  Google Scholar 

  • Takaku F (1990) Clinical use of human granulocyte colony stimulating factor. In: Clark SC, Golde DW (eds) Hematopoiesis. Liss, New York, pp 217–227

    Google Scholar 

  • Talpaz M, McCredie KB, Mavligit GM, Gutterman JU (1983) Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia. Blood 62:689–692

    PubMed  Google Scholar 

  • Talpaz M, Kantarijian HM, McCredic KB, Trujillo JM, Keating MJ, Gutterman JU (1986) Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia. N Engl J Med 314:1065–1069

    PubMed  Google Scholar 

  • Taylor K, Jagannath S, Spitzer G, Spinolo JA, Tucker SL, Fogel B, Cabanillas FF, Magemeister EB, Souza LM (1989) Recombinant human granulocyte colony-stimulating factor hastens granulocyte recovery after high-dose chemotherapy and autologous bone marrow transplantation in Hodgkin's disease. J Clin Oncol 7:1791–1799

    PubMed  Google Scholar 

  • Tepper RI, Mule JJ (1994) Experimental and clinical studies of cytokine gene-modified tumor cells. Human Gene Ther 5:153–164

    Google Scholar 

  • The Japanese Society of Pediatric Hematology Bone Marrow Transplantation Committee (1994) National registry of bone marrow transplantation in children—1993. Jpn J Pediatr Hematol 8232–8242

  • Tiberghien P, Reynolds CW, Keller J, Spence S, Deschaseaux M, Certoux JM, Contassot E, Murphy WJ, Lyons R, Chiang Y, Merve P, Longo DL, Ruscetti FW (1994) Gancyclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation? Blood 84: 1333–1341

    PubMed  Google Scholar 

  • To LB, Roberts MM, Haylock DN, Dysin PG, Braniford AL, Thorp D, Ho K, Dart GW, Horvath N, Davy MLJ, Olwney CLM, Abdi E, Juttner CA (1992) Comparison of haematological recovery times and supportive care requirements of autologous recovery phase peripheral blood stem cell transplants, autologous bone marrow-transplants and allogeneic bone marrow transplants. Bone Marrow Transplant 9:277–284

    PubMed  Google Scholar 

  • Tricot G, Jagannath S, Vesoli D, Nelson J, Tinelli S, Miller L, Cheson B, Crowley J, Barlogie B (1995) Peripheral blood stem cell transplants for multiple myeloma. Identification of favorable variables for rapid engraftment in 225 patients. Blood 85:585–596

    Google Scholar 

  • Uckun FM, Kersey JH, Haake R, Weisdorf D, Ramsay NKC (1992) Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CD10) plus complement and 4-hydroxyperoxycyclophos-phamide for ex vivo marrow purging. Blood 79:1094–1104

    PubMed  Google Scholar 

  • Verdonck LF, Dekker AE, De Gast GC, Lokhorst HM, Nieuwenhuis HK (1992) Autologous bone marrow transplantation for adult poor-risk lymphoblastic lymphoma in first remission. J Clin Oncol 10:644–646

    PubMed  Google Scholar 

  • Wadler S, Schwartz EL, Goldman M, Lyver A, Rader M, Zimmerman M, Itri L, Weinberg V, Wiernik PH (1989) Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma. J Clin Oncol 7:1769–1775

    PubMed  Google Scholar 

  • Weiden PL, Flournoy N, Thomas ED, Prentice R, Fefer A, Buckner CD, Storb B (1979) Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med 300:1068–1073

    PubMed  Google Scholar 

  • Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Boreton-Gorius J, Cosman D, Vainchenker W (1994) cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571–574

    PubMed  Google Scholar 

  • Zittoun RA, Mandelli F, Willemze R, de Witte T, Labar B, Resegotti L, Leoni F, Damasio E, Visani G, Papa G, Caronia F, Hayat M, Stryckmans P, Rotoli B, Leoni P, Peetermans ME, Dardenne M, Vegna ML, Petti MC, Solbu G, and Suciu S for the EOR and EORTC and GIMENA Leukemia Cooperative Groups (1995) Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in actue myelogenous leukemia. N Engl J Med 332:217–223

    PubMed  Google Scholar 

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  1. International Medical Center of Japan, Toyama 1-21-1, 162, Tokyo, Japan

    Fujimaro Takaku

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Takaku, F. Cytokines and bone marrow transplantation. J Cancer Res Clin Oncol 121, 701–709 (1995). https://doi.org/10.1007/BF01213315

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