References
Barber, G. & Spaeth, G. (1969). The successful treatment of homocystinuria with pyridoxine.Journal of Pediatrics, 75, 463–474.
Bendich, A., & Cohen, M. (1990). Vitamin B6 safety issues.Annals of the New York Academy of Science, 585, 321–337.
Cohen, M. & Bendich, A. (1986). Safety of pyridoxine—A review of human and animal studies.Toxicology Letters, 34, 129–146.
Freeman, B. J., Ritvo, E. R., Yokota, A., & Ritvo, A. (1986). A scale for rating symptoms of patients with the syndrome of autism in real life settings.Journal of the American Academy of Child Psychiatry, 25, 130–136.
Gerger, A. & Schaumburg, A. (1984). More on neuropathy from pyridoxine abuse.New England Journal of Medicine, 311, 986–988.
Gill, H. S., & Rose, G. A. (1986). Mild metabolic hyperoxaluria and its response to pyridoxine.Urology International, 41, 393–396.
Kasdan, M. L., & Janes, C. (1987). Carpal tunnel syndrome and vitamin B6.Plastic and Reconstructive Surgery, 79, 456–466.
Lelord, G., Callaway, E. & Much, J. P., (1982). Clinical and biological effects of high doses of Vitamin B6 and magnesium on autistic children.Acta Vitaminology and Enzymology, 4, 27–36.
Lelord, G., Much, J. P., Barthélémy, C., Martineau, J. & Garreau, B. (1981). Effects of pyridoxine and magnesium on autistic symptoms—initial observations.Journal of Autism and Developmental Disorders, 11, 219–223.
Martineau, J., Barthélémy, C., Chelickine, C., & Lelord, G. (1988). Brief Report: An open middle term study of combined Vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.Journal of Autism and Developmental Disorders, 18, 435–443.
Martineau, J., Barthélémy, C., Garreau, B., & Lelord, G. (1985). Vitamin B6, magnesium, and combined B6−Mg: Therapeutic effects of childhood autism.Biological Psychiatry, 20, 467–473.
Martineau, J., Barthélémy, C. & Lelord, G. (1986). Long-term effects of combined Vitamin B6-magnesium administration in an autistic child.Biological Psychiatry, 21, 511–519.
Martineau, J., Barthélémy, C., Roux, S., Garreau, B., & Lelord, G. (1989). Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behavior.Developmental Medicine and Childhood Neurology, 31, 721–726.
Martineau, J., Garreau, B., Barthélémy, C., Callaway, E., & Lelord, G. (1981). Effects of vitamin B6 on average evoked potentials in infantile autism.Biological Psychiatry, 16, 627–635.
O'Brien, P. M. S. (1982). The premenstrual syndrome: A review of the present status of therapy.Drugs, 24, 140–161.
Pettit, R. E. (1987). Pyridoxine dependency seizures: Report of a case with unusual features.Journal of Childhood Neurology, 2, 38–41.
Rimland, B. (1973). High dosage levels of certain vitamins in the treatment of children with severe mental disorders. In D. Hawkins & L. Pauling (Eds.),Orthomolecular psychiatry. San Francisco: W. H. Freeman.
Rimland, B., Callaway, E., & Dreyfuss, P. (1978). The effects of high doses of vitamin B6 on autistic children: A double-blind cross-over study.American Journal of Psychiatry, 135, 472–478.
Schaumburg, H., Kaplan, J., Windebank, A., Vick, N., Rasmus, S., Pleasure, D., & Brown, M. J. (1983). Sensory neuropathy from pyridoxine.New England Journal of Medicine, 309, 445–447.
Author information
Authors and Affiliations
Additional information
The authors thank Ted Butterworth, Tom Vaughan, and Al Bartolucci, as well as the staff of Allan Cott School for their assistance with this project. We also thank Hoffmann LaRoche for the pyridoxine and placebo.
Rights and permissions
About this article
Cite this article
Tolbert, L., Haigler, T., Waits, M.M. et al. Brief report: Lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium. J Autism Dev Disord 23, 193–199 (1993). https://doi.org/10.1007/BF01066428
Issue Date:
DOI: https://doi.org/10.1007/BF01066428