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Brain muscarinic cholinergic receptors in Huntington's disease

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Summary

Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the total number of muscarinic receptors and of M-2 receptors in the hippocampus while the density of M-1 receptors was unaltered. Muscarinic receptor binding was unchanged in the temporal cortex. These results indicate a degeneration in Huntington's disease of the septo-hippocampul cholinergic pathway, but no impairment of the innominato-cortical cholinergic system.

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References

  1. American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd edn. American Psychiatric Association, Washington, DC

    Google Scholar 

  2. Bird ED, Iversen LL (1974) Huntington's chorea: post-mortem measurement of glutamic acid decarboxylase, choline acerytransferase and dopamine in basal ganglia. Brain 97:457–472

    Google Scholar 

  3. Clark AW, Parhard IM, Folstein SE, et al (1983) The nucleus basalis in Huntington's disease. Neurology 33:1262–1267

    Google Scholar 

  4. Kuwert T, Lange HW, Langen K-J, Herzog H, Aulich A, Feinendegen LE (1990) Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease. Brain 113:1405–1423

    Google Scholar 

  5. Lange KW, Wells FR, Rossor MN, Jenner P, Marsden CD (1989) Brain muscarinic receptors in Alzheimer's disease and Parkinson's disease. Lancet II:1279

    Google Scholar 

  6. Mann DMA (1989) Subcortical affarent projection systems in Huntington's chroea. Acta Neuropathol (Berl) 78:551–554

    Google Scholar 

  7. Perry EK, Tomlinson BE, Blessed G, Bergmann K, Gibson PH, Perry RH (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile damentia. BMJ 11:1457–1459

    Google Scholar 

  8. Perry EK, Curtis M, Dick DJ, et al (1985) Cholinergic correlates of cognitive impairment in Parkinson's disease: comparison with Alzheimer's disease. J Neurol Neurosurg Psychiatry 48:413–421

    Google Scholar 

  9. Ruberg M, Ploska A, Javoy-Agid F, Agid Y (1982) Muscarinic binding and choline acetyltransferase activity in Parkinsonian subjects with reference to dementia. Brain Res 232:129–139

    Google Scholar 

  10. Spokes EGS (1980) Neurochemical alterations in Huntington's chorea: a study of post-mortem brain tissue. Brain 103:179–210

    Google Scholar 

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Lange, K.W., Javoy-Agid, F., Agid, Y. et al. Brain muscarinic cholinergic receptors in Huntington's disease. J Neurol 239, 103–104 (1992). https://doi.org/10.1007/BF00862983

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  • DOI: https://doi.org/10.1007/BF00862983

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