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Th1/Th2 balance in cancer, transplantation and pregnancy

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References

  1. Adorini L, Guery JC, Ria F, Galbiati F (1997) B cells present antigen to CD4+ T cells, but fail to produce IL-12. Selective APC for Th2 cell development? Ann N Y Acad Sci 815:401

    Google Scholar 

  2. al-Saleh W, Giannini SL, Jacobs N, Moutschen M, Doyen J, Boniver J, Delvenne P (1998) Correlation of T-helper secretory differentiation and types of antigen- presenting cells in squamous intraepithelial lesions of the uterine cervix. J Pathol 184: 283

    Google Scholar 

  3. Ashkenazi E, Deutsch M, Tirosh R, Weinreb A, Tsukerman A, Brodie C (1997) A selective impairment of the IL-2 system in lymphocytes of patients with glioblastomas: increased level of soluble IL-2R and reduced protein tyrosine phosphorylation. Neuroimmunomodulation 4:49

    Google Scholar 

  4. Asselin-Paturel C, Echchakir H, Carayol G, Gay F, Opolon P, Grunenwald D, Chouaib S, Mami-Chouaib F (1998) Quantitative analysis of Th1, Th2 and TGF-beta1 cytokine expression in tumor, TIL and PBL of non-small cell lung cancer patients. Int J Cancer 77:7

    Google Scholar 

  5. Beissert S, Hosoi J, Grabbe S, Asahina A, Granstein RD (1995) IL-10 inhibits tumor antigen presentation by epidermal antigen- presenting cells. J Immunol 154: 1280

    Google Scholar 

  6. Berghella AM, Pellegrini P, Del Beato T, Marini M, Tomei E, Adorno D, Casciani CU (1998) The significance of an increase in soluble interleukin-2 receptor level in colorectal cancer and its biological regulating role in the physiological switching of the immune response cytokine network from TH1 to TH2 and back. Cancer Immunol Immunother 45:241

    Google Scholar 

  7. Bertagnolli MM, Takai Y, Herrmann SH (1991) IL-4-supported induction of cytolytic T lymphocytes requires IL-2 and IL-6. Cell Immunol 133: 327

    Google Scholar 

  8. Bulmer JN, Morrison L, Longfellow M, Ritson A, Pace D (1991) Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies. Hum Reprod 6: 791

    Google Scholar 

  9. Chan SY, DeBruyne LA, Goodman RE, Eichwald EJ, Bishop DK (1995) In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 59:1155

    Google Scholar 

  10. Chen N, Gao Q, Field EH (1996) Prevention of Th1 response is critical for tolerance. Transplantation 61:1076

    Google Scholar 

  11. Chen Q, Daniel V, Maher DW, Hersey P (1994) Production of IL-10 by melanoma cells: examination of its role in immunosuppression mediated by melanoma. Int J Cancer 56:755

    Google Scholar 

  12. Chen WE, Zlotnik A (1991) IL-10: a novel cytotoxic T cell differentiation factor. J Immunol 147:528

    Google Scholar 

  13. Chen YM, Yang WK, Ting CC, Tsai WY, Yang DM, Whang-Peng J, Perng RP (1997) Cross regulation by IL-10 and IL-2/IL-12 of the helper T cells and the cytolytic activity of lymphocytes from malignant effusions of lung cancer patients. Chest 112: 960

    Google Scholar 

  14. Chouaib S, Asselin-Paturel C, Mami-Chouaib F, Caignard A, Blay JY (1997) The host-tumor immune conflict: from immunosuppression to resistance and destruction. Immunol Today 18: 493

    Google Scholar 

  15. Clark DA, Chaouat G, Arck PC, Mittruecker HW, Levy GA (1998) Cytokine-dependent abortion in CBA x DBA/2 mice is mediated by the procoagulant fg12 prothombinase. J Immunol 160:545

    Google Scholar 

  16. Clerici M, Ferrario E, Trabattoni D, Viviani S, Bonfanti V, Venzon DJ, Clerici E, Shearer GM, Villa ML (1994) Multiple defects of T helper cell function in newly diagnosed patients with Hodgkin's disease. Eur J Cancer 10: 1464

    Google Scholar 

  17. Clerici M, Shearer GM, Clerici E (1998) Cytokine dysregulation in invasive cervical carcinoma and other human neoplasias: time to consider the TH1/TH2 paradigm. J Natl Cancer Inst 90: 261

    Google Scholar 

  18. Conrad KP, Benyo DF (1997) Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol 37:240

    Google Scholar 

  19. Conrad KP, Miles TM, Benyo DF (1998) Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 40:102

    Google Scholar 

  20. Cortes J, Kurzrock R (1997) Interleukin-10 in non-Hodgkin's lymphoma. Leuk Lymphoma 26:251

    Google Scholar 

  21. Croy B, Reed N, Malashenko B, Kim K, Kwon B (1991) Demonstration of YAC target cell lysis by murine granulated metrial gland cells. Cell Immunol 133: 116

    Google Scholar 

  22. Cunningham DA, Dunn MJ, Yacoub MH, Rose ML (1994) Local production of cytokines in the human cardiac allograft. A sequential study. Transplantation 57: 1333

    Google Scholar 

  23. Damle RN, Advani SH, Gangal SG (1991) Impairment in proliferation, lymphokine production and frequency distribution of mitogen-responsive and interleukin-2-producing cells in Hodgkin's disease. Cancer Immunol Immunother 34:205

    Google Scholar 

  24. De Smedt T, Van Mechelen M, De Becker G, Urbain J, Leo O, Moser M (1997) Effect of interleukin-10 on dendrifc cell maturation and function. Eur J Immunol 27: 1229

    Google Scholar 

  25. De Totero D, Reato G, Mauro F, Cignetti A, Ferrini S, Guarini A, Gobbi M, Grossi CE, Foa R (1999) IL-4 production and increased CD30 expression by a unique CD8+ T -cell subset in B-cell chronic lymphocytic leukaemia. Br J Haematol 104: 589

    Google Scholar 

  26. Di Renzo M, Rubegni P, De Aloe G, Paulesu L, Pasqui AL, Andreassi L, Auteri A, Fimiani M (1997) Extracorporeal photochemotherapy restores Th1/Th2 imbalance in patients with early stage cutaneous T-cell lymphoma. Immunology 92:99

    Google Scholar 

  27. Donckier V, Wissing M, Bruyns C, Abramowicz D, Lybin M, Vanderhaeghen ML, Goldman M (1995) Critical role of interleukin 4 in the induction of neonatal transplantation tolerance. Transplantation 59:1571

    Google Scholar 

  28. Elliott L, Brooks W, Roszman T (1987) Role of interleukin-2 (IL-2) and IL-2 receptor expression in the proliferative defect observed in mitogen-stimulated lymphocytes from patients with gliomas. J Natl Cancer Inst 78: 919

    Google Scholar 

  29. Elliott LH, Brooks WH, Roszman TL (1984) Cytokinetic basis for the impaired activation of lymphocytes from patients with primary intracranial tumors. J Immunol 132: 1208

    Google Scholar 

  30. Elsasser-Beile U, Kolble N, Grussenmeyer T, Schultze-Seemann W, Wetterauer U, Gallati H, Schulte Morning J, Kleist S von (1998) Th1 and Th2 cytokine response patterns in leukocyte cultures of patients with urinary bladder, renal cell and prostate carcinomas. Tumour Biol 19: 470

    Google Scholar 

  31. Enk AH, Jonuleit H, Saloga J, Knop J (1997) Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Inn J Cancer 73: 309

    Google Scholar 

  32. Esche C, Lokshin A, Shurin GV, Gastman BR, Rabinowich H, Watkins SC, Lotze MT, Shurin MT (1999) Tumor's other immune targets: dendritic cells. J Leukoc Biol 66: 336

    Google Scholar 

  33. Flexner S, Jobling JW (1907) On the promoting influence of heated tumor emulsions on tumor growth. Proc Soc Exp Biol Med 4: 156

    Google Scholar 

  34. Fortis C, Foppoli M, Gianotti L, Galli L, Citterio G, Consogno G, Gentilini O, Braga M (1996) Increased interleukin-10 serum levels in patients with solid tumours. Cancer Lett 104: 1

    Google Scholar 

  35. Fried M, Muga R, Misore A, Duffy P (1998) Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcome. J Immunol 160: 2523

    Google Scholar 

  36. Fujisao S, Tsuda H (1998) Th1/Th2 balance alteration in the clinical course of a patient with pure red cell aplasia and thymoma. Br J Haematol 103: 308

    Google Scholar 

  37. Ghosh P, Komschlies KL, Cippitelli M, Longo DL, Subleski J, Ye J, Sica A, Young HA, Wiltrout RH, Ochoa AC (1995) Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth. J Natl Cancer Inst 87: 1478

    Google Scholar 

  38. Goedegebuure PS, Douville CC, Doherty JM, Linehan DC, Lee KY, Ganguly EK, Eberlein TJ (1997) Simultaneous production of T helper-1-like cytokines and cytolytic activity by tumor-specific T cells in ovarian and breast cancer. Cell Immunol 175: 150

    Google Scholar 

  39. Grohmann U, Silla S, Belladonna ML, Bianchi R, Orabona C, Puccetti P, Moretti MC (1997) Circulating levels of 1L-10 are critically related to growth and rejection patterns of murine mastocytoma cells. Cell Immunol 181: 109

    Google Scholar 

  40. Groux H, Cottrez F, Rouleau M, Mauze S, Antonenko S, Hurst S, McNeil T, Bigler M, Roncarolo MG, Coffman RL (1999) A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells. J Immunol 162: 1723

    Google Scholar 

  41. Guimond MJ, Luross JA, Wang B, Terhorst C, Danial S, Croy BA (1997) Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice. Biol Reprod 56:169

    Google Scholar 

  42. Hall BM (1991) Cells mediating allograft rejection [published erratum appears in Transplantation (1991):936]. Transplantation 51: 1141

    Google Scholar 

  43. Handel-Fernandez ME, Cheng X, Herbert LM, Lopez DM (1997) Down-regulation of IL-12, not a shift from a T helper-1 to a T helper-2 phenotype, is responsible for impaired IFN-γ production in mammary tumor-bearing mice. J Immunol 158: 280

    Google Scholar 

  44. Hara N, Fujii T, Okai T, Taketan iY (1995) Histochemical demonstration of interleukin-2 in decidua cells of patients with preeclampsia. Am J Reprod Immunol 34: 44

    Google Scholar 

  45. Hauer AC, Finn TM, MacDonald TT, Spencer J, Isaacson PG (1997) Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT type lymphomas stimulated in vitro withHelicobacter pylori. J Clin Pathol 50:957

    Google Scholar 

  46. Hirshberg B, Kramer MR, Lotem M, Barak V, Shustin L, Amir G, Ben-Yehuda D, Ben-Yehuda A (1999) Chronic eosinophilic pneumonia associated with cutaneous T-cell lymphoma. Am J Hematol 60: 143

    Google Scholar 

  47. Hrouda D, Baban B, Dunsmuir WD, Kirby RS, Dalgleish AG (1998) Immunotherapy of advanced prostate cancer: a phase I/II trial usingMycobacterium vaccae (SRL172). Br J Urol 82:568

    Google Scholar 

  48. Hu HM, Urba WJ, Fox BA (1998) Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell response from a type 2 to a type 1 cytokine profile. J Immunol 161:3033

    Google Scholar 

  49. Huang M, Wang J, Lee P, Sharma S, Mao JT, Meissner H, Uyemura K, Modlin R, Wollman J, Dubinett SM (1995) Human non-small cell lung cancer cells express a type 2 cytokine pattern. Cancer Res 55:3847

    Google Scholar 

  50. Huettner C, Paulus W, Roggendorf W (1995) Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas. Am J Pathol 146: 317

    Google Scholar 

  51. Inagawa H, Nishizawa T, Honda T, Nakamoto T, Takagi K, Soma G (1998) Mechanisms by which chemotherapeutic agents augment the antitumor effects of tumor necrosis factor: involvement of the pattern shift of cytokines from Th2 to Th1 in tumor lesions. Anticancer Res 18: 3957

    Google Scholar 

  52. Ito N, Nakamura H, Tanaka Y, Ohgi S (1999) Lung carcinoma: analysis of T helper type 1 and 2 cells and T cytotoxic type 1 and 2 cells by intracellular cytokine detection with flow cytometry. Cancer 85: 2359

    Google Scholar 

  53. Jacobs N, Giannini SL, Doyen J, Baptista A, Moutschen M, Boniver J, Delvenne P (1998) Inverse modulation of IL-10 and IL-12 in the blood of women with preneoplastic lesions of the uterine cervix. Clin Exp Immunol 111: 219

    Google Scholar 

  54. Jokhi P, King A, Sharkey A, Smith S, Loke Y (1994) Screening for cytokine messenger ribonucleic acids in purified human. J Immunol 153:4427

    Google Scholar 

  55. Kalinski P, Schuitemaker JH, Hilkens CM, Kapsenberg ML (1998) Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+Cd83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J Immunol 161: 2804

    Google Scholar 

  56. Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P (1999) The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Clin Exp Allergy 29 [Suppl 2]:33

    Google Scholar 

  57. Kaushic C, Frauendorf E, Rossoll R, Richardson J, Wira C (1998) Influence of the estrous cycle on the presence and distribution of immune. Am J Reprod Immunol 39:209

    Google Scholar 

  58. Kavanaugh DY, Carbone DP (1996) Immunologic dysfunction in cancer. Hematol Oncol Clin North Am 10: 927

    Google Scholar 

  59. Kearns M, Lala PK (1982) Bone marrow origin of decidual cell precursors in the pseudopregnant mouse uterus. J Exp Med 155:1537

    Google Scholar 

  60. Kim J, Modlin RL, Moy RL, Dubinett SM, McHugh T, Nickoloff BJ, Uyemura K (1995) IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response. J Immunol 155: 2240

    Google Scholar 

  61. King A, Wellings V, Gardner L, Loke YW (1989) Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle. Hum Immunol 24:195

    Google Scholar 

  62. Klentzeris LD, Bulmer JN, Warren A, Morrison L, Li TC, Cooke ID (1992) Endometrial lymphoid tissue in the timed endometrial biopsy: morphometric and immunohistochemical aspects. Am J Obstet Gynecol 167: 667

    Google Scholar 

  63. Kobayashi M, Kobayashi H, Pollard RB, Suzuki F (1998) A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastasis of murine B 16 melanoma. J Immunol 160: 5869

    Google Scholar 

  64. Krasnow J, Tollerud D, Naus G, DeLoia J (1996) Endometrial Th2 cytokine expression throughout the menstrual cycle and early pregnancy. Hum Reprod 11: 1747

    Google Scholar 

  65. Krishnan L, Guilbert L, Russell A, Wegmann T, Mosmann T, Belosevic M (1996) Pregnancy impairs resistance of C57BL/6 mice toLeishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines. J Immunol 156: 644

    Google Scholar 

  66. Krishnan L, Guilbert L, Wegmann T, Belosevic M, Mosmann T (1996) T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-γ and TNF and reduced IL-10 production by placental cells. J Immunol 156:653

    Google Scholar 

  67. Kruger-Krasagakis S, Krasagakis K, Garbe C, Schmitt E, Huls C, Blankenstein T, Diamantstein T (1994) Expression of interleukin 10 in human melanoma. Br J Cancer 70:1182

    Google Scholar 

  68. Lang T, Krams SM, Martinez OM (1996) Production of IL-4 and IL-10 does not lead to immune quiescence in vascularized human organ grafts. Transplantation 62: 776

    Google Scholar 

  69. Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, Winn KJ, Pearson TC (1996) Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434

    Google Scholar 

  70. Lee PP, Zeng D, McCaulay AE, Chen YF, Geiler C, Umetsu DT, Chao NJ (1997) T helper 2-dominant antilymphoma immune response is associated with fatal outcome. Blood 90:1611

    Google Scholar 

  71. Lin H, Mosmann TR, Guilbert L, Tuntipopipat S, Wegmann TG (1993) Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol 151:4562

    Google Scholar 

  72. Liu L, Rich BE, Inobe J, Chen W, Weiner HL (1998) Induction of Th2 cell differentiation in the primary immune response: dendritie cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4. Int Immunol 10: 1017

    Google Scholar 

  73. Lowes MA, Bishop GA, Crotty K, Bametson RS, Halliday GM (1997) T helper 1 cytokine mRNA is increased in spontaneously regressing primary melanomas. J Invest Dermatol 108: 914

    Google Scholar 

  74. Lowry RP, Konieczny B, Alexander D, Larsen C, Pearson T, Smith S, Narula S (1995) Interleukin-10 eliminates anti-CD3 monoclonal antibody-induced mortality and prolongs heart allograft survival in inbred mice. Transplant Proc 27: 392

    Google Scholar 

  75. Luo Y, Chen X, Downs TM, DeWolf WC, O'Donnell MA (1999) IFN-alpha 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guerin immunotherapy. J Immunol 162: 2399

    Google Scholar 

  76. Macatonia SE, Hsieh CS, Murphy KM, O'Garra A (1993) Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma- dependent. Int Immunol 5: 1119

    Google Scholar 

  77. Maeda H, Shiraishi A (1996) TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice. J Immunol 156:73

    Google Scholar 

  78. Maeda H, Takata M, Takahashi S, Ogoshi S, Fujimoto S (1994) Adoptive transfer of a Th2-like cell line prolongs MHC class II antigen disparate skin allograft survival in the mouse. Int Immunol 6: 855

    Google Scholar 

  79. Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12:991

    Google Scholar 

  80. Miller CL, Hooton JW, Gillis S, Paetkau V (1990) IL-4 potentiates the IL-2-dependent proliferation of mouse cytotoxic T cells. J Immunol 144: 1331

    Google Scholar 

  81. Mondino A, Khoruts A, Jenkins MK (1996) The anatomy of T -cell activation and tolerance. Proc Natl Acad Sci USA 93:2245

    Google Scholar 

  82. Mosmann TR, Sad S (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138

    Google Scholar 

  83. Nakagomi H, Pisa P, Pisa EK, Yamamoto Y, Halapi E, Backlin K, Juhlin C, Kiessling R (1995) Lack of interleukin-2 (IL-2) expression and selective expression of IL- 10 mRNA in human renal cell carcinoma. Int J Cancer 63: 366

    Google Scholar 

  84. Onishi T, Ohishi Y, Imagawa K, Ohmoto Y, Murata K (1999) An assessment of the immunological environment based on intratumoral cytokine production in renal cell carcinoma. British Journal of Urol Int 83:488

    Google Scholar 

  85. Ota H, Igarashi S, Tanaka T (1996) Expression of gamma delta T cells and adhesion molecules in endometriotic tissue in patients with endometriosis and adenomyosis. Am J Reprod Immunol 35:477

    Google Scholar 

  86. Pellegrini P, Berghella AM, Del Beato T, Cicia S, Adorno D, Casciani CU (1996) Disregulation in TH1 and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol Immunother 42: 1

    Google Scholar 

  87. Piccotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK (1996) IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol 157: 1951

    Google Scholar 

  88. Piccotti JR, Li K, Chan SY, Eichwald EJ, Bishop DK (1999) Cytokine regulation of chronic cardiac allograft rejection: evidence against a role for Th1 in the disease process. Transplantation 67: 1548

    Google Scholar 

  89. Pollard JW, Hunt JS, Wiktor-Jedrzejczak W, Stanley ER (1991) A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol 148: 273

    Google Scholar 

  90. Powell TJ, Jr., Streilein JW (1990) Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells. J Immunol 144: 854

    Google Scholar 

  91. Prasad AS, Beck FW, Doerr TD, Shamsa FH, Penny HS, Marks SC, Kaplan J, Kucuk O, Mathog RH (1998) Nutritional and zinc status of head and neck cancer patients: an interpretive review. J Am Coll Nutr 17:409

    Google Scholar 

  92. Punnonen R, Teisala K, Kuoppala T, Bennett B, Punnonen J (1998) Cytokine production profiles in the peritoneal fluids of patients with malignant or benign gynecologic tumors. Cancer 83:788

    Google Scholar 

  93. Qian S, Li W, Li Y, Fu F, Lu L, Fung JJ, Thomson AW (1996) Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice. Transplantation 62: 1709

    Google Scholar 

  94. Qin L, Chavin KD, Ding Y, et al (1995) Multiple vectors effectively achieve gene transfer in a routine cardiac transplantation model. Immunosuppression with TGF-beta 1 or V IL-10. Transplantation 59:809

    Google Scholar 

  95. Reinartz S, Boerner H, Koehler S, Von Ruecker A, Schlebusch H, Wagner U (1999) Evaluation of immunological responses in patients with ovarian cancer treated with the anti-idiotype vaccine ACA125 by determination of intracellular cytokines — a preliminary report. Hybridoma 18:41

    Google Scholar 

  96. Ria F, Penna G, Adorini L (1998) Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells. Ent J Immunol 28: 2003

    Google Scholar 

  97. Rosen HR, Ausch C, Reinerova M, Zaspin E, Renner K, Rosen AC, Schiessel R, Moroz C (1998) Activated lymphocytes from breast cancer patients express the characteristics of type 2 helper cells — a possible role for breast cancer-associated p43. Cancer Lett 127: 129

    Google Scholar 

  98. Rosenberg AS, Singer A (1992) Cellular basis of skin allograft rejection: an in vivo model of immunemediated tissue destruction. Annu Rev Immunol 10: 333

    Google Scholar 

  99. Roussel E, Gingras MC, Grimm EA, Brunet JM, Moser RP (1996) Predominance of a type 2 intratumoural immune response in fresh tumour- infiltrating lymphocytes from human gliomas. Clin Exp Immunol 105:344

    Google Scholar 

  100. Saed G, Fivenson DP, Naidu Y, Nickoloff BJ (1994) Mycosis fungoides exhibits a Th1-type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2-type profile. J Invest Dermatol 103: 29

    Google Scholar 

  101. Saito S, Nishikawa K, Morii T, Enomoto M, Narita N, Motoyoshi K, Ichijo M (1993) Cytokine production by Cd16-CD56bright natural killer cells in the human early pregnancy decidua. Int Immunol 5: 559

    Google Scholar 

  102. Salom R, Maguire J, Esmore D, Hancock W (1995) Endothelial cell activation and cytokine expression during acute human cardiac allograft rejection. Transplant Proc 27: 2164

    Google Scholar 

  103. Sato M, Goto S, Kaneko R, Ito M, Sato S, Takeuchi S (1998) Impaired production of Th1 cytokines and increased frequency of Th2 subsets in PBMC from advanced cancer patients. Anticancer Res 18: 3951

    Google Scholar 

  104. Sayegh MH, Akalin E, Hancock WW, Russell ME, Carpenter CB, Linsley PS, Turka LA (1995) CD28B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 181:1869

    Google Scholar 

  105. Schoof DD, Terashima Y, Peoples GE, Goedegebuure PS, Andrews JV, Richie JP, Eberlein TJ (1993) CD4+ T cell clones isolated from human renal cell carcinoma possess the functional characteristics of Th2 helper cells. Cell Immunol 150: 114

    Google Scholar 

  106. Schuler T, Qin Z, Ibe S, Noben-Trauth N, Blankenstein T (1999) T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice. J Exp Med 189: 803

    Google Scholar 

  107. Serrano D, Ghiotto F, Roncella S, Airoldi I, Cutrona G, Truini M, Burgio VL, Baroni CD, Ferrarini M, Pistoia V (1997) The patterns of IL-2, IFN-gamma, IL-4 and IL-5 gene expression in Hodgkin's disease and reactive lymph nodes are similar. Haematologica 82:542

    Google Scholar 

  108. Shurin MR, Esche C, Lokshin A, Lotze MT (1999) Apoptosis in dendritic cells. In: Lotze MT, Thomson AW (eds) Dendritic cells: biology and clinical applications. Academic Press, San Diego, p 673

    Google Scholar 

  109. Sirianni MC, Vincenzi L, Fiorelli V, Topino S, Scala E, Uccini S, Angeloni A, Faggioni A, Cerimele D, Cottoni F, Aiuti F, Ensoli B (1998) γ-Interferon production in peripheral blood mononuclear cells and tumor infiltrating lymphocytes from Kaposi's sarcoma patients: correlation with the presence of human herpesvirus-8 in peripheral blood mononuclear cells and lesional macrophages. Blood 91: 968

    Google Scholar 

  110. Smith DR, Kunkel SL, Burdick MD, Wilke CA, Orringer MB, Whyte RI, Stricter RM (1994) Production of interleukin-10 by human bronchogenic carcinoma. Am J Pathol 145:18

    Google Scholar 

  111. Sredni B, Tichler T, Shani A, Catane R, Kaufman B, Strassmann G, Albeck M, Kalechman Y (1996) Predominance of TH1 response in tumor-bearing mice and cancer patients treated with AS101. J Natl Cancer Inst 88: 1276

    Google Scholar 

  112. Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB (1995) IL-2 knockout recipient mice reject islet cell allografts. J Immunol 155:489

    Google Scholar 

  113. Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159:4772

    Google Scholar 

  114. Stewart I, Mukhtar D (1988) The killing of mouse trophoblast cells by granulated metrial gland cells in vitro. Placenta 9:417

    Google Scholar 

  115. Stewart-Akers AM, Krasnow JS, Brekosky (1998) Endometrial leukocytes are altered numerically and functionally in women with implantation defects. Am J Reprod Immunol 39: 1

    Google Scholar 

  116. Stinn JL, Taylor MK, Becker G, Nagano H, Hasegawa S, Furakawa Y, Shimizu K, Libby P, Mitchell RN (1998) Interferon-gamma-secreting T -cell populations in rejecting murine cardiac allografts: assessment by flow cytometry. Am J Pathol 153: 1383

    Google Scholar 

  117. Strom TB, Roy-Chaudhury P, Manfro R, Zheng XX, Nickerson PW, Wood K, Bushell A (1996) The Th1/Th2 paradigm and the allograft response. Curr Opin Immunol 8: 688

    Google Scholar 

  118. Suthanthiran M (1997) Molecular analyses of human renal allografts: differential intragraft gene expression during rejection. Kidney Int Suppl 58:S15

    Google Scholar 

  119. Tabata T, Hazama S, Yoshino S, Oka M (1999) Th2 subset dominance among peripheral blood T lymphocytes in patients with digestive cancers. Am J Surg 177: 203

    Google Scholar 

  120. Tadmori W, Zhang M, Beavis AJ, Sullivan LM, Narula SK (1994) Suppression of the allogeneic response by human IL-10: a critical role for suppression of a synergy between IL-2 and TNF-alpha. Cytokine 6:462

    Google Scholar 

  121. Takeuchi T, Lowry RP, Konieczny B (1992) Heart allografts in marine systems. The differential activation of Th2- like effector cells in peripheral tolerance. Transplantation 53: 1281

    Google Scholar 

  122. Tangri S, Raghupathy R (1993) Expression of cytokinesin placentas of mice undergoing immunologically mediated spontaneous fetal resorptions. Biol Reprod 49: 850

    Google Scholar 

  123. Tendler CL, Burton JD, Jaffe J, Danielpour D, Charley M, McCoy JP, Pittelkow MR, Waldmann TA (1994) Abnormal cytokine expression in Sezary and adult T-cell leukemia cells correlates with the functional diversity between these T-cell malignancies. Cancer Res 54: 4430

    Google Scholar 

  124. Toellner KM, Luther SA, Sze DM, Choy RK, Taylor DR, MacLennan ICM, Acha-Orbea H (1998) T helper I (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J Exp Med 187:1193

    Google Scholar 

  125. Toungouz M, Denys C, Groote D de, Andrien M, Dupont E (1996) Optimal control of interferongamma and tumor necrosis factor-alpha by interleukin-10 produced in response to one HLA-DR mismatch during the primary mixed lymphocyte reaction. Transplantation 61:497

    Google Scholar 

  126. Tovey MG, Benizri E, Gugenheim J, Bernard G, Eid P, Blanchard B, Hofman P (1996) Role of the type I interferons in allograft rejection. J Leukoc Biol 59: 512

    Google Scholar 

  127. Turka LA (1998) What's new in transplant immunology: problems and prospects. Ann Intern Med 128:946

    Google Scholar 

  128. Van den Hove LE, Van Gool SW, Van Poppel H, Baert L, Coorevits L, Van Damme B, Ceuppens JL (1997) Phenotype, cytokine production and cytolytic capacity of fresh (uncultured) tumour-infiltrating T lymphocytes in human renal cell carcinoma. Clin Exp Immunol 109:501

    Google Scholar 

  129. Wang Q, Redovan C, Tubbs R, Olencki T, Klein E, Kudoh S, Finke J, Bukowski RM (1995) Selective cytokine gene expression in renal cell carcinoma tumor cells and tumor-infiltrating lymphocytes. Int J Cancer 61:780

    Google Scholar 

  130. Wegmann TG, Lin H, Guilbert L, Mosmann TR (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunology Today 14: 353

    Google Scholar 

  131. White H, Crassi K, Givan A, Stern J, Gonzalez J, Memoli V, Green W, Wira C (1997) CD8 CTL activity within the human female reproductive tract: influence of stage of the menstrual cycle and menopause. J Immunol 158: 3017

    Google Scholar 

  132. Wong CP, Okada CY, Levy R (1999) TCR vaccines against T cell lymphoma: QS-21 and IL-12 adjuvants induce a protective CD8+ T cell response. J Immunol 162:2251

    Google Scholar 

  133. Yahata T, Kurabayashi T, Honda A, Takakuwa K, Tanaka K (1998) Decrease in the proportion of granulated CD56+ T -cells in patients with a history of recurrent abortion. J Reprod Immunol 38: 63

    Google Scholar 

  134. Yamamum M, Modlin RL, Ohmen JD, Moy RL (1993) Local expression of antiinflammatory cytokines in cancer. J Clin Invest 91: 1005

    Google Scholar 

  135. Zhai Y, Ghobrial RM, Busuttil RW. Kupiec-Weglinski JW (1999) Th1 and Th2 cytokines in organ transplantation: paradigm lost? Crit Rev Immunol 19: 155

    Google Scholar 

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Authors and Affiliations

  1. Biologic Therapy and Surgical Oncology Program, University of Pittsburgh Cancer Institute, 200 Lothrop Street, W1540 BST, Pittsburgh, PA, 15261, USA

    Michael R. Shurin, Lina Lu, Pawel Kalinski, Ann M. Stewart-Akers & Michael T. Lotze

  2. Department of Surgery, University of Pittsburgh Medical Center, 15213, Pittsburgh, PA, USA

    Michael T. Lotze

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  1. Michael R. Shurin
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  2. Lina Lu
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  3. Pawel Kalinski
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  4. Ann M. Stewart-Akers
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  5. Michael T. Lotze
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Shurin, M.R., Lu, L., Kalinski, P. et al. Th1/Th2 balance in cancer, transplantation and pregnancy. Springer Semin Immunopathol 21, 339–359 (1999). https://doi.org/10.1007/BF00812261

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