Abstract
The effects of chronic treatment (5 mg b.i.d. for 2 days followed by 10 mg b.i.d. for 5 days) with R 58 735 on human memory functions were studied in healthy elderly (age ≥50 years) volunteers in a double-blind placebo-controlled study. Serial learning of nonsense syllables was better under R 58 735, and relearning 1 week after termination of the treatment was superior to relearning of similar material initially learned under placebo. Free recall of nonsense syllables was significantly better when these were learned under active compound. Proactive inhibition induced by consecutive presentation of word lists was attenuated by R 58 735. Short-term memory functions, retrieval accuracy from semantic memory and unprepared reaction times were unchanged. R 58 735 ameliorated both learning and recall in conditions of age-related mild hypofunction in healthy volunteers. The compound seems to have had positive effects on encoding and consolidation of new material.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Clincke G, Saghal A (1986) R 58 735, a novel antihypoxic drug improves memory in rats. Drug Dev Res 8:381–385
Corkin S, Cohen NJ, Sullivan EV, Clegg RA, Rosen TJ, Ackerman RH (1985) Analysis of global memory impairments of different etiologies. In: Olton DS, Ganzu E, Corkin S (eds) Memory dysfunctions: an integration of animal and human research from preclinical and clinical perspectives. Ann NY Acad Sci 444:10–40
Irving G, Robinson RA, McAdam W (1970) The validity of some cognitive tests in the diagnosis of dementia. Br J Psychiatry 117:149–156
Keppel G (1973) Design and analysis. A researcher's handbook. Prentice Hall, Englewood Cliffs
Rosch E (1975) Cognitive representations of semantic categories. J Exp Psychol 104:192–233
Van de Velde V, Van Peer A, Tritsmans L, Gasparini R, Woestenborghs R, Heykants J, Amery W (1986) Single and repeated dose pharmacokinetics of R 58 735 in healthy volunteers. Pharm Weekbl (Sci) 8:311
Verstraeten A, Vandenberghe J, Coussement W, Van Cauteren H, Marsboom R (1986a) Subchronic toxicity study in Beagle dogs (3 months). Preclinical Research Report, Janssen Pharmaceutica
Verstraeten A, Vandenberghe J, Coussement W, Van Cauteren H, Marsboom R (1986b) Subchronic toxicity study in Wistar rats (3 months). Preclinical Research Report, Janssen Pharmaceutica
Wauquier A, Clincke G, Ashton D, De Ryck M, Fransen J, Van Clemen G (1986) R 58 735: A new antihypoxic drug with anticonvulsant properties and possible effects on cognitive functions. Drug Dev Res 8:373–380
Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Clincke, G.H.C., Tritsmans, L., Idzikowski, C. et al. The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers. Psychopharmacology 94, 52–57 (1988). https://doi.org/10.1007/BF00735880
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00735880