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Taxol encapsulation in poly(ɛ-caprolactone) microspheres

  • Original Article
  • Taxol, Microspheres Antiangiogenesis
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Abstract

Poly(ɛ-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.

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Dordunoo, S.K., Jackson, J.K., Arsenault, L.A. et al. Taxol encapsulation in poly(ɛ-caprolactone) microspheres. Cancer Chemother. Pharmacol. 36, 279–282 (1995). https://doi.org/10.1007/BF00689043

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  • DOI: https://doi.org/10.1007/BF00689043

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