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Adenosine 5′-monophosphate, an internal regulatory agent, is a potent chemoattractant for a marine shrimp

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Summary

  1. 1.

    The nucleotide adenosine 5′-monophosphate (AMP) is a potent chemoattractant for the marine shrimp,Palaemonetes pugio. Behavioral bioassays of AMP in the concentration range of 0.1 to 1000 μmol/l show that the dose-response curve is biphasic with the maximum response occurring at about 10 μmol/l.

  2. 2.

    AMP is much more potent than ADP. ATP and adenosine are inactive as attractants.

  3. 3.

    Bioassays of 28 substances structurally related to AMP show that the integrity of both the adenosine and the ribose phosphate moieties are required for maximal activity. However, the integrity of the ribose phosphate is of special importance since most of the substances having changes in this moiety are completely inactive as attractants.

  4. 4.

    The response to AMP is antagonized by theophylline and adenosine.

  5. 5.

    The behavioral results suggest that the shrimp possesses external chemoreceptors with marked similarities to the R-type, or P1-type, purine receptors that are present internally in vertebrate tissues.

  6. 6.

    Comparisons are made of the structure-activity relationships of nucleotides stimulating behavioral responses in the shrimp and other lower organisms. Possible evolutionary relationships between external chemoreceptors in lower organisms and internal receptors for neurotransmitters and modulators are noted.

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Abbreviations

AMP :

adenosine 5′-monophosphate

IMP :

inosine 5′-monophosphate

UMP :

uridine 5′-monophosphate

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Authors and Affiliations

  1. C.V. Whitney Laboratory for Experimental Marine Biology and Medicine, University of Florida, 32084, St. Augustine, FL, USA

    William E. S. Carr

  2. Department of Zoology and Physiology, Louisiana State University, 70803, Baton Rouge, LA, USA

    Hilary W. Thompson

Authors
  1. William E. S. Carr
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  2. Hilary W. Thompson
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Carr, W.E.S., Thompson, H.W. Adenosine 5′-monophosphate, an internal regulatory agent, is a potent chemoattractant for a marine shrimp. J. Comp. Physiol. 153, 47–53 (1983). https://doi.org/10.1007/BF00610341

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  • DOI: https://doi.org/10.1007/BF00610341

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