Summary
Insulin has been shown to decrease sodium, potassium and water excretion by direct action on the kidney. Reduction of sodium excretion is due to enhanced tubular reabsorption as a probable consequence of stimulated active sodium transport. The renal effect of insulin is demonstrated with plasma hormone concentration observable in pathophysiological conditions; it offers therefore a possible explanation for some clinical findings such as the changes in sodium, potassium and water excretion occurring in man after fasting and subsequent glucose feeding.
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Nizet, A., Lefebvre, P. & Crabbé, J. Control by insulin of sodium potassium and water excretion by the isolated dog kidney. Pflugers Arch. 323, 11–20 (1971). https://doi.org/10.1007/BF00586561
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DOI: https://doi.org/10.1007/BF00586561