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Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney

  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
  • Published:
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Abstract

  1. 1.

    Renal handling of pig-and rat-insulin was studied in the isolated perfused rat kidney.

  2. 2.

    Metabolic clearance rates of both pig- and rat-insulin excceded GFR.

  3. 3.

    Peritubular uptake of pig-insulin accounted for 13%, of rat-insulin for 31% of the total metabolic clearance.

  4. 4.

    The nonfiltering kidney does not remove insulin from the peritubular circulation.

  5. 5.

    Metabolic clearance rates of pig- and rat-insulin are directly related to GFR.

  6. 6.

    The filtration process seems to be necessary for the uptake of insulin at the peritubular site.

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Authors and Affiliations

  1. Zentrum Innere Medizin and Zentrum Physiologie, Medizinische Hochschule Hannover, D-3000, Hannover, Federal Republic of Germany

    Eberhard Schlatter, Hans-Joachim Schurek & Reinhard Zick

Authors
  1. Eberhard Schlatter
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  2. Hans-Joachim Schurek
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  3. Reinhard Zick
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Supported by the Deutsche Forschungsgemeinschaft

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Schlatter, E., Schurek, HJ. & Zick, R. Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney. Pflugers Arch. 393, 227–231 (1982). https://doi.org/10.1007/BF00584074

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  • DOI: https://doi.org/10.1007/BF00584074

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