Skip to main content
Log in

Histomorphometry of iliac crest trabecular bone in adult male baboons in captivity

  • Laboratory Investigations
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Summary

Dat in the literature on bone histomorphometry in the baboon are scant. This study provides data from analysis of trabecular bone of the iliac crest of 16 adult male chacma baboons (Papio ursinus) in captivity. Five animals were young adults judging by the presence of growth cartilage in the iliac crest biopsy. Bone volume resembled that in humans, but trabeculae were thinner and more closely spaced. Bone turnover appeared somewhat lower than in humans. Coupling of resorption and formation was excellent as judged by cellular and kinetic variables; erosion surface was an unreliable indicator of ongoing coupling. The similarities between human and baboon trabecular bone make the baboon suited for the study of microstructure and bone turnover of trabecular bone with relevance to humans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jerome CP, Kimmel DG, McAlister JA, Weaver DS (1986) Effects of ovariectomy on iliac trabecular bone in baboons (Papio anubis). Calcif Tissue Int 39:206–208

    Google Scholar 

  2. Goodwin BT, Jerome CP (1987) Iliac biopsy for histomorphometric analysis of trabecular bone in cynomolgus monkeys and baboons. Lab Anim Sci 37:213–216

    Google Scholar 

  3. Pettifor JM, Marie PJ, Sly MR, Du Bruyn DB, Ross FP, Isdale JM, De Klerk WA, Van der Walt WH (1984) The effect of differing dietary calcium and phosphorus contents on mineral metabolism and bone histomorphometry in young vitamin D-replete baboons. Calcif Tissue Int 36:668–676

    Google Scholar 

  4. Ripamonti U, Ma S, Cunningham NS, Yeates L, Reddi AH (1992) Initiation of bone regeneration in adult baboons by osteogenin, a bone morphogenetic protein. Matrix Coll Rel Res 12:369–380

    Google Scholar 

  5. Thompson DD, Seedor JG, Quartuccio H, Solomon H, Fioravanti C, Davidson J, Klein H, Jackson R, Clair J, Frankenfield D, Brown E, Simmons HA, Rodan GA (1992) The bisphosphonate, Alendronate, prevents bone loss in ovariectomized baboons. J Bone Miner Res 7:951–960

    Google Scholar 

  6. Aufdermorte T, Buffum K, Fox C, Miller D (1992) A potential animal model for the study of osteoporosis and oral bone loss (abstract). Bone 13:A2

    Google Scholar 

  7. Aufdemorte TB, Fox WC, Holt GR, McGuff HS, Ammann AJ (1992) An intraosseous device for studies of bone healing. J Bone Joint Surg 74A:1153–1161

    Google Scholar 

  8. Frost HM (1973) Remodeling as a determinant of envelope physiology. In: Frost HM (ed) Bone remodeling and its relationship to metabolic bone diseases. Charles C Thomas, Springtield, p 51

    Google Scholar 

  9. Nogues C, Milhaud DFM (1988) A new technique for iliac crest biopsy in rhesus monkeys for use in weightlessness experiments: some results of ground studies. Aviat Space Environ Med April: 374–378

  10. Durnova GN, Vorotnikova EV, Sakharova ZF, Kaplanskii AS, Kniazev VM, Dochenko MA (1989) Histomorphologic study of the bones of monkeys after 14-day anti-orthostatic hypokinesia. Kosm Biol Aviaksom Med 23:22–26

    Google Scholar 

  11. Durnova GN, Vorotnikova EV, Kaplanskii AS, Novikov VE (1990) Osteoporosis in monkeys after antiorthostatic hypokinesia. Kosm Biol Aviakosm Med (USSR) 24:29–31

    Google Scholar 

  12. Yamaguchi A, Kohno Y, Yamazaki T et al (1986) Bone in the marmoset: a resemblance to vitamin D-dependent rickets. Calcif Tissue Int 39:22–27

    Google Scholar 

  13. Melton DA, Melton CL (1982) Blood parameters of the wild chacma baboon,Papio ursinus. S Afr J Zool 17:85–90

    Google Scholar 

  14. Dreyer JJ, Du Bruyn DB (1968) Composition of a food mixture developed at the NNRI for supplementation of predominantly cereal diets. S Afr Med J 42:600–604

    Google Scholar 

  15. Ripamonti U (1991) The morphogenesis of bone in replicas of porous hydroxyapatite obtained from conversion of calcium carbonate exoskeletons of coral. J Bone Joint Surg 73A:692–703

    Google Scholar 

  16. Melsen F, Mosekilde L (1981) The role of bone biopsy in the diagnosis of metabolic bone disease. Orthop Clin North Am 12:571–602

    Google Scholar 

  17. Malluche HH, Meyer W, Sherman D, Massry SG (1982) Quantitative bone histology in 84 normal American subjects. Morphometric analysis and evaluation of variance in iliac bone. Calcif Tissue Int 34:449–455

    Google Scholar 

  18. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche HH, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols and units. J Bone Miner Res 2:595–610

    Google Scholar 

  19. Nordin BEC, Young MM, Bulusu L, Horsman A (1970) Osteoporosis re-examined. In: Barzel US (ed) Osteoporosis. Grune and Stratton, New York, pp 47–67

    Google Scholar 

  20. Villanueva AR, Mathews CHE, Parfitt AM (1981) Relationship between the size and shape of osteoblasts and the width of osteoid seams in bone. In: Takahashi H (ed) The Second Japanese Workshop on Histomorphometry. University School of Medicine, Niigata, pp 191–196

    Google Scholar 

  21. Schnitzler CM, Pettifor JM, Mesquita JM, Bird MDT, Schnaid E, Smyth AE (1990) Histomorphometry of iliac crest bone in 346 normal black and white South African adults. Bone Miner 10:183–199

    Google Scholar 

  22. Croucher PI, Mellish RWE, Vedi S, Garrahan NJ, Compston JE (1989) The relationship between resorption depth and mean interstitial bone thickness: age-related changes in man. Calcif Tissue Int 45:15–19

    Google Scholar 

  23. Gray's Anatomy (1938) Longmans, Green and Co, London, pp 352, 378

  24. Lips P, Courpron P, Meunier P (1978) Mean wall thickness of trabecular bone packets. Metab Bone Dis Rel Res 26:13–17

    Google Scholar 

  25. Malluche HH, Faugere MC (1990) Bone biopsies: histology and histomorphometry of bone. In: Avioli LV, Krane SM (eds) Metabolic bone disease and clinically related disorders. WB Saunders Co, Philadelphia, pp 283–328

    Google Scholar 

  26. Schnitzler CM, Kok JA, Jacobs DW, Thomson PD, Milne FJ, Mesquita JM, King PC, Fabian VA (1991) Skeletal manifestations of primary oxalosis. Pediatr Nephrol 5:193–199

    Google Scholar 

  27. De Rousseau CJ (1985) Aging in the musculoskeletal system of rhesus monkeys. III. Bone loss. Am J Phys Anthropol 68:157–167

    Google Scholar 

  28. Pope NS, Gould KG, Anderson DC, Mann DR (1989) Effects of age and sex on bone density in the rhesus monkey. Bone 10: 109–112

    Google Scholar 

  29. Bowden DM, Teets C, Witkin J, Young DM (1979) Long bone calcification and morphology. In: Bowden DW (ed) Aging in non-human primates. van Nostrand Reinhold Co, New York, pp 335–347

    Google Scholar 

  30. Pettifor JM, Schnitzler CM, Ross FP, Moodley GP (1989) Endemic skeletal fluorosis in children: hypocalcaemia and the presence of renal resistance to parathyroid hormone. Bone Miner 7:275–288

    Google Scholar 

  31. Young DR, Niklowitz WJ, Brown RJ, Jee WSS (1986) Immobilization-associated osteoporosis in primates. Bone 7:109–117

    Google Scholar 

  32. Cann CE, Genant HK, Young DR (1980) Comparison of vertebral and peripheral mineral losses in disuse osteoporosis in monkeys. Radiology 134:525–529

    Google Scholar 

  33. Young DR, Schneider VS (1986) Radiographic evidence of disuse osteoporosis in the monkey (M. nemestrina). Calcif Tissue Int 33:631–639

    Google Scholar 

  34. Schock CC, Noyes FR, Crouch MM, Mathews CHE (1975) The effects of immobility on long bone remodeling in the rhesus monkey. Henry Ford Hosp Med J 23:107–116

    Google Scholar 

  35. Minaire P, Meunier P, Edouard C, Bernard J, Bourret J (1974) Quantitative histological data on disuse osteoporosis. Calcif Tissue Res 17:57–73

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schnitzler, C.M., Ripamonti, U. & Mesquita, J.M. Histomorphometry of iliac crest trabecular bone in adult male baboons in captivity. Calcif Tissue Int 52, 447–454 (1993). https://doi.org/10.1007/BF00571335

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00571335

Key words

Navigation