Summary
The nucleotide sequence of a 1.76 Kbp segment from rat liver mitochondrial DNA has been determined. It contains the gene for the cytochrome b apoprotein and the tRNA genes for threonine, glutamic acid, and proline. The arrangement of these genes in rat liver mitochondria is the same as in human (Anderson et al. 1981) or mouse (Bibb et al. 1981) mitochondria. The comparison of the cytochrome b sequences so far determined, reveals that several regions in these proteins are highly conserved.
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Anderson S, Bankier AT, Barrell BG, de Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DC, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG (1981) Nature 290:457–464
Anderson S, De Bruijn MLH, Coulson AR, Eperon IC, Sanger F, Young IG (1982) J Mol Biol 156:683–717
Bibb MJ, van Etten RA, Wright CT, Walberg MW, Clayton DA (1981) Cell 26:167–180
Birnboim HC, Doly J (1979) Nucleic Acids Res 7:1513–1523
Bolivar F, Rodriguez RL, Greene PJ, Betlach MC, Heynecker HL, Boyer HW, Crosa JH, Falkow S (1977) Gene 2:95–113
Brown WM, Wilson AC (1979) Proc Natl Acad Sci USA 76:1967–1971
Buzzo K, Fouts DL, Wolstenholme DR (1978) Proc Natl Acad Sci USA 75:909–913
Feldmann H, Grosskopf R (1979) Curr Genet 1:13–19
Grosskopf R, Feldmann H (1981a) Curr Genet 4:151–158
Grosskopf R, Feldmann H (1981b) Curr Genet 4:191–196
Kobayashi M, Yaginuma K, Seki T, Koike K (1980) In: Kroon AM, Saccone C (eds) The Organization and Expression of the Mitochondrial Genome. Elsevier/North Holland, Amsterdam, pp 221–229
Kobayashi M, Seki T, Yaginuma K, Koike K (1981) Gene 16:297–307
Lederberg EM, Cohen SN (1974) J Bacteriol 119:1072–1074
Montoya J, Ojala D, Attardi G (1981) Nature 290:465–470
Nobrega FG, Tzagoloff A (1980) J Biol Chemistry 225:9828–9837
Pech M, Streeck RE, Zachau HG (1979) Cell 18:883–893
Saccone C, Cantatore P, Gadaleta G, Gallerani R, Lanave C, Pepe G, Kroon AM (1981) Nucleic Acids Res 9:4139–4148
Sekiya T, Kobayashi M, Seki T, Koike K (1980) Gene 11:53–62
Upholt WB, Dawid IB (1979) Cell 11:571–583
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Abbreviations: Cyt b, cytochrome b apoprotein; U.R.F., unidentified reading frame (Anderson et al. 1981). Other abbreviations follow IUB-IUPAC conventions
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Görtz, G., Feldmann, H. Nucleotide sequence of the cytochrome B gene and adjacent regions from rat liver mitochondrial DNA. Curr Genet 5, 221–225 (1982). https://doi.org/10.1007/BF00391810
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DOI: https://doi.org/10.1007/BF00391810