Abstract
Primary malignant non-Hodgkin's lymphomas account for 0.4% of malignant neoplasms arising in the bladder and female urethra, but do not comprise a uniform group, and three subgroups can be identified which account for a majority of cases. The most common is a low-grade B-cell lymphoma similar to neoplasms arising in the mucosa-associated lymphoid tissue at other sites — so-called ‘MALTomas’. These generally display indolent behavior. A second group accounting for approximately one-fifth of cases is composed almost entirely of large lymphoid cells, and these tumors have a poor prognosis. A third possible group comprises only a few patients who present with diffuse thickening of the bladder wall, and have a poor prognosis. The authors present a new case which suggests that this latter group may be of T-cell origin. In addition to these three subtypes, others no doubt await recognition. The different forms of primary lymphoma appear to require different treatments, and some guidelines are proposed.
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References
Sufrin G, Keogh B, Moore RH, Murphy GP. Secondary involvement of the bladder in malignant lymphoma. J Urol 1977;118:251–253
Simpson RHW, Bridger JE, Anthony PP, James KA, Jury I. Malignant lymphoma of the lower urinary tract: a clinicopathological study with review of the literature. Br J Urol 1990;65:254–260
Bhansali SK, Cameron KM. Primary malignant lymphoma of the bladder. Br J Urol 1960;32:440–454
Grabstald H, Hilaris B, Henschke U, Whitmore WF. Cancer of the female urethra. JAMA 1966;197:835–842
Pak K, Takayama H, Tomoyoshi T, Takeoka O. Reticulum cell sarcoma of the female urethra: report of a case. Acta Urol Japan 1980;26:599–601
Touhami H, Brahimi S, Kubisz P, Cronberg S. Non-Hodgkin's lymphoma of the female urethra. J Urol 1987;137:991–992
Nabholtz JM, Friedman S, Tremeaux JC et al. Non-Hodgkin's lymphoma of the urethra: a rare extranodal entity. Gynecol Oncol 1989;35:110–111
Mark JA, Pais VM, Chong FK. Plasmacytoma of the urethra treated with transurethral resection and radiotherapy. J Urol 1990;143:1010–1011
Sanchez Garcia A, Martinez AA, Martinez RC. Linfoma vesical asociado a carcinoma papilar. Arch Esp Urol 1988;41:317–318
Binkovitz LA, Hattery RR, LeRoy AJ. Primary lymphoma of the bladder. Urol Radiol 1988;9:231–233
Lancina Martin JA, Garrido JML, Campora RG, Perez MG, Martin MA. Linfoma maligno primitivo de vejiga. Arch Esp Urol 1989;42:269–272
Jones MW, Primary Hodgkin's disease of the urinary bladder. Br J Urol 1989;63:438
Davidson NGP, Primary non-Hodgkin's lymphoma of the bladder: case report and review of the literature. Scand J Urol Nephrol 1990;24:155–156
Kuhara H, Tamura Z, Suchi T, Hattori R, Kinukawa T. Primary malignant lymphoma of the urinary bladder: a case report. Acta Pathol Japan 1990;40:764–769
Pecze K, Kisbenedek L, Szepeshazi K, Jakab I. Primer hugyholyag lymphoma. Orvosi Hetilap 1990;131:1979–1981
Murayama K, Katsumi T, Watanabe K, Konishi K. Primary malignant lymphoma of the urinary bladder: report of a case. Hinyokika Kiyo 1990;36:697–700
Kashi SH, Murphy JK, Britton JP, Whelan P. Primary lymphoma of the bladder: a clinicopathological study of 3 cases. Eur Urol 1990;17:186–188
Guthman DA, Malek RS, Chapman WR, Farrow GM. Primary malignant lymphoma of the bladder. J Urol 1990;144:1367–1369
Pawade J, Wright DH, Isaacson PG. MALT lymphoma of the bladder. (Abstract) J Pathol 1991;164:353A
Gorfain AD, Extramedullary plasmacytoma of the bladder with local metastasis. Calif Med 1949;71:147–148
Tremann JA, Norris HT, McRoberts JW. Lymphoproliferative disease of the bladder. J Urol 1971;106:687–691
Minervini R, Mansoni T, Aragona F, Fiorentini L. Linfoma primitivo de la vejiga asociado a carcinoma: descripcion de un caso. Arch Esp Urol 1982;35:341–344
Ozan O, Guler M. Extramedullary plasmacytoma of the bladder. Acta Urol Belg 1986;54:431–433
Siegelbaum MH, Edmonds P, Seidmon EJ. Use of immunohistochemistry for identification of primary lymphoma of the bladder. J Urol 1986;136:1074–1076
Mincione GP, Primary malignant lymphoma of the urinary bladder with a positive cytologic report. Acta Cytol 1982;26:69–72
Blomjous CEM, Vos W, de Voogt HJ, van der Walk P, Meijer CJLM. Small cell carcinoma of the urinary bladder: a clinicopathologic, morphometric, immunohistochemical, and ultrastructural study of 18 cases. Cancer 1989;64:1347–1357
Zukerberg LR, Harris NL, Young RH. Carcinomas of the urinary bladder simulating malignant lymphoma: a reportof five cases. Am J Surg Pathol 1991;15:569–576
National Cancer Institute. National Cancer Institute sponsored study of classification of non-Hodgkin's lymphomas. Summary and description of a working formulation for clinical usage. The non-Hodgkin's lymphoma pathologic classification project. Cancer 1982;49:2112–2135
Stansfeld AG, Diebold J, Kapanci Y, Kelengi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundstrom C, van Unnik JAM, Wright DH. Updated Kiel classification for lymphomas. Lancet 1988;i:292–293
Hall PA, Levison DA. Malignant lymphoma in the gastrointestinal tract. Semin Diagn Pathol 1991;8:163–177
Isaacson PG (Commentary). Lymphomas of mucosa-associated lymphoid tissue (MALT). Histopathology 1990;16:617–619
Bejany DE, Lockhart JL, Rhamy RK. Malignant vesical tumors following spinal cord injury. J Urol 1987;138:1390–1392
Harris NL, Extranodal lymphoid infiltrates and mucosaassociated lymphoid tissue (MALT): a unifying concept (Editorial). Am J Surg Pathol 1991;15:879–884
Lebowich J. Hodgkin's disease involving the bladder: report of a case. Am J Cancer 1937;30:758–764
Moloney GE, Lymphosarcoma of the bladder: report of a case. Br J Surg 1947;35:91–94
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Simpson, R.H.W., Amin, R.S. & Pocock, R.D. Malignant lymphoma of the bladder and female urethra. Int Urogynecol J 5, 102–105 (1994). https://doi.org/10.1007/BF00375823
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DOI: https://doi.org/10.1007/BF00375823