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Prevalences of CT-detected calcification in the basal ganglia in idiophathic hypoparathyroidism and pseudohypoparathyroidism

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Summary

Sixteen patients with idiopathic hypoparathyroidism (IHP) and eight patients with pseudohypoparathyroidism (PHP) were examined by CT scan of the brain. Calcification in the basal ganglia was observed in 11 patients with IHP (69%) and in all eight patients with PHP. Of the 19 patients with basal ganglia calcification, nine had calcification in the cerebral cortex (47%), and four had calcification in the cerebellum (21%). Observation of basal ganglia calcification on CT gave rise to suspicion of IHP or PHP in three patients (12%). The remaining patients were examined at varying time after diagnosis. Since arrest in growth of calcification after institution of treatment has never been proven, the reported prevalences of calcification may not be valid to the situation at the time of diagnosis.

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References

  1. Löwenthal A, Bruyn GW (1968) Calcification of the striopallidodentate system. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, Vol 6 North Holland, Amsterdam, pp 703–729

    Google Scholar 

  2. Frame B (1976) Neuromuscular manifestations of parathyooid disease. In: Vinken PJ, Bruyn GW, Klawans, HL (eds) Handbook of clinical neurology, Vol 27 North Holland, Amsterdam, pp 283–320

    Google Scholar 

  3. Bronsky D, Kushner DS, Dubin A, Snapper I (1958) Idiopathic hypoparathyroidism and pseudohypoparathyroidism: Case reports and review of the literature. Medicine (Baltimore) 37: 317–352

    Google Scholar 

  4. Norman D, Diamond C, Boyd D (1978) Relative detectability of intracranial calcifications on computed tomography and skull radiography. J Comput Assist Tomogr 2:61–64

    Google Scholar 

  5. Murphy MJ (1979) Clinical correlations of CT-scan detected calcifications of the basal ganglia. Ann Neurol 6:507–511

    Google Scholar 

  6. Keck E, Schuier FJ, Thörner G, Ischebeck W, Durdel R, Wiegelmann W (1978) Symmetrische, intrakranielle Verkalkungen bei gestörter Nebenschilddrüsenfunktion. Med Klin 73: 1507–1512

    Google Scholar 

  7. Pellock JM, Behrens M, Lewis L, Holub D, Carter S, Rowland LP (1978) Kearns-Sayre syndrome and hypoparathyroidism. Ann Neurol 3:455–458

    Google Scholar 

  8. Guberman A, Jaworski ZFG (1979) Pseudohypoparathyroidism and epilepsy: Diagnostic value of computerized cranial tomography. Epilepsia 20:541–553

    Google Scholar 

  9. Hochman HI (1979) Idiopathic (pseudoidiopathic?) hypoparathyroidism. Am J Dis Child 133:435–436

    Google Scholar 

  10. Logan KR (1979) Pseudo-pseudohypoparathyroidism developing pseudohypoparathyroidism. Ir J Med Sci 148:194

    Google Scholar 

  11. Seigel RS, Seeger JF, Gabrielsen TO, Allen RJ (1979) Computed tomography in oculocraniosomatic disease (Kearns-Sayre syndrome). Radiology 130:159–164

    Google Scholar 

  12. Walters RO (1979) Idiopathic hypoparathyroidism with extrapyramidal and myopathic features. Arch Dis Child 54: 236–238

    Google Scholar 

  13. Forman MB, Sandler MP, Danziger A, Kalk WG (1980) Basal ganglia calcifications in postoperative hypoparathyroidism. Clin Endocrinol 12:385–390

    Google Scholar 

  14. Arisaka O (1981) A case of pseudohypoparathyroidism associated with remarkable intracranial calcification. Horumon To Rinsho 29:151–154

    Google Scholar 

  15. Nagashima C, Kubota S (1981) Parathyroid epilepsy with continuous EEG abnormality. Clin Electroencephalogr 12: 133–138

    Google Scholar 

  16. Pearson DWM, Durward WF, Fogelman I, Boyle IT, Beastall G (1981) Pseudohypoparathyroidism presenting as severe parkinsonism. Postgr Med J 57:445–447

    Google Scholar 

  17. Windeck R, Menken U, Benker G, Reinwein D (1981) Basal ganglia calcification in pseudohypoparathyroidism type II. Clin Endocrinol 15:57–63

    Google Scholar 

  18. Fantesini C, Lucci B, Manicardi E, Pilastri G, Valcavi R (1982) Sindrome neurologica protratta tetanica e sincopale da ipoparatiroidismo idiopatico con calcificazioni endocraniche. Riv Neurobiol 27:315–320

    Google Scholar 

  19. Mateo D, Gimenez-Roldan S (1982) Dementia in idiopathic hypoparathyroidism. Arch Neurol 39:424–425

    Google Scholar 

  20. Sachs C, Sjöberg HE, Ericsson K (1982) Basal ganglia calcifications on CT: Relation to hypoparathyroidism. Neurology (NY) 32:779–782

    Google Scholar 

  21. Savettieri G, Butera C, Lupo I, Giordano D (1982) Cerebral calcinosis and hypoparathyroidism. Acta Neurol (Napoli) 37:209–211

    Google Scholar 

  22. Smits M, Gabreëls F, Froeling P, Thijssen H, Colon E, ter Haar B, Ruland C, 't Lam R (1982) Autosomal dominant idiopathic hypoparathyroidism and nervous system dysfunction: report of three cases and review of the lieerature. J Neurol 228: 113–122

    Google Scholar 

  23. Hansted C, Holst G (1952) Changes in dental tissues in hypoparathyroidism. Acta Odontol Scand 10:70–74

    Google Scholar 

  24. Hansted C, Brandt S (1953) Electroencephalographic changes in siblings with hypocalcemia due to hypoparathyroidism. Electroencephalogr. Clin Neurophysiol 5:101–104

    Google Scholar 

  25. Risum G (1973) Psoriasis exacerbated by hypoparathyroidism with hypocalcemia. Br J Dermatol 89:309–312

    Google Scholar 

  26. Frederiksen PK, Jacobsen JG (1980) Pseudohypoparathyroidism. A 25-year delay in diagnosis. Acta Med Scand 207: 341–344

    Google Scholar 

  27. Hyldstrup L, Ladefoged SD, Aastrup H (1981) Reversible dementia in idiopathic hypoparathyroidism. Dan Med Bull 28: 74–75

    Google Scholar 

  28. Rasmusson B, Roesdahl K, Lindgren P (1978) Parathyroid hormone and calcitonin in serum of patients with mammary carcinoma. Acta Radiol Oncol Radiat Phys Biol 17:269–276

    Google Scholar 

  29. Soelling H (1981) A rapid and inexpensive radioimmunoassay for parathyroid hormone utilizing the Wide-principle in combination with an improved separation technique. Clin Chim Acta 116:349–359

    Google Scholar 

  30. Christensen MS (1976) A sensitive radioimmunoassay of parathyroid hormone in human serum using a specific extraction procedure. Scand J Clin Invest 36:313–322

    Google Scholar 

  31. Tomlinson S, Hendy GN, O'Riordan LHH (1976) A simplified assessment of response to paratyyroid hormone in hypoparathyroid patients. Lancet I:62–64

    Google Scholar 

  32. Tovey KC, Oldham KG, Whelan JAM (1974) A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique. Clin Chim Acta 56:221–234

    Google Scholar 

  33. Deuxchaisnes NC, Krane SM (1978) Hypoparathyroidism. In: Avioli LV, Krane SM (eds) Metabolic bone disease vol II. Academic Press, New York, pp 217–445

    Google Scholar 

  34. Schwarz G (1964) Pseudohypoparathyreoidismus und Pseudo-Pseudohypoparathyreoidismus. Springer, Berlin Göttingen Heidelberg New York, pp 96–97

    Google Scholar 

  35. Alterman SL, Lieber AL (1965) Albright's hereditary osteodystrophy. The effect of treatment during adolescence. Ann Intern Med 3:140–146

    Google Scholar 

  36. Hastings-James R (1970) Lenticulodentate calcification. Radiology 97:571–576

    Google Scholar 

References

  1. Koller WC, Cochran JW, Klawans HL (1979) Calcification of the basal ganglia: Computerized tomography and clinical correlation. Neurology (NY) 29:328–333

    Google Scholar 

  2. Murphy MJ (1979) Clinical correlations of CT-scan detected calcifications of the basal ganglia. Ann Neurol 6:507–511

    Google Scholar 

  3. Sachs C, Ericson K, Erasmie U, Bergström M (1979) Incidence of basal ganglia calcifications on computed tomography. J Comput Assist Tomogr 3:339–344

    Google Scholar 

  4. Aii H, Kameyama M, Nakano Y, Handa J (1980) Calcification of basal ganglia on computed tomography. No To Shinkei 32: 971–979

    Google Scholar 

  5. Brannan TS, Burger AA, Chaudhary MY (1980) Bilateral basal ganglia calcifications visualised on CT scan. J Neurol Neurosurg Psychiatry 43:403–406

    Google Scholar 

  6. Cohen CR, Duschesneau PM, Weinstein A (1980) Calcification of the basal ganglia as visualized by computed tomography. Radiology 134:97–99

    Google Scholar 

  7. Goldscheider HG, Lischewski R, Claus D, Streibl W, Waiblinger G (1980) Klinische, endokrinologische und computertomographische Untersuchungen zur symmetrischen Stammganglienverkalkung (M Fahr). Arch Psychiatr Nervenkr 228: 53–65

    Google Scholar 

  8. Smith D, Bloch S, Al-Raschid RA (1980) Basal ganglia calcification on CT scanning in children with acute lymphocytic leukemia. Neuroradiology 20:91–93

    Google Scholar 

  9. Graham J, Jayasinghe L, Baddeley H (1981) Cerebellar calcification. Diagn Imaging 50:99–106

    Google Scholar 

  10. Harrington MG, Macpherson P, McIntosh WB, Allam BF, Bone I (1981) The significance of the incidental finding of basal ganglia calcification on computed tomography. J Neurol Neurosurg Psychiatry 44:1168–1170

    Google Scholar 

  11. Vles JSH, Lodder J, van der Lugt PJM (1981) Clinical significance of basal ganglia calcifications detected by CT. Clin Neurol Neurosurg 83:253–256

    Google Scholar 

  12. Puvanendran K, Low CH, Boey HK, Tan KP (1982) Basal ganglia calcification on computer tomographic scan. Acta Neurol Scand 66:309–315

    Google Scholar 

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Authors and Affiliations

  1. Department of Neuroradiology P, Radiology and Neurology, University of Aarhus, Municipal Hospital, Aarhus, Denmark

    F. Illum & E. Dupont

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  1. F. Illum
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  2. E. Dupont
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Illum, F., Dupont, E. Prevalences of CT-detected calcification in the basal ganglia in idiophathic hypoparathyroidism and pseudohypoparathyroidism. Neuroradiology 27, 32–37 (1985). https://doi.org/10.1007/BF00342514

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  • DOI: https://doi.org/10.1007/BF00342514

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