Summary
Neurons containing a central pale area which may possibly represent an early cytoplasmic change before Lewy body maturation were observed in the substantia nigra from a rare autopsy case of juvenile parkinsonism. Ultrastructurally, such neurons exhibited cytoplasmic swelling along with disappearance of the rough endoplasmic reticulum from the central part of the perikaryon. The pale central cytoplasm was replaced by numerous-cored vesicles, mitochondria, ribosomelike granules and a few Lewy body filaments. The relation of this central pale area to the pale body is discussed.
References
Dale GE, Probst A, Luthert P, Martin J, Anderton BH, Leigh PN (1992) Relationships between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathol 83:525–529
Duffy PE, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus caeruleus in Parkinson's disease. J Neuropathol Exp Neurol 24:398–414
Forno LS (1986) The Lewy body in Parkinson's disease. Adv Neurol 45:35–43
Forno LS, Alvord EC (1974) Depigmentation in the nerve cells of the substantia nigra and locus ceruleus in Parkinsonism. Adv Neurol 5:195–202
Forno LS, Norville RL (1976) Ultrastructure of Lewy bodies in the satellate ganglion. Acta Neuropathol (Berl) 34:183–197
Gibb WRG (1986) Idiopathic Parkinson's disease and the Lewy body disorders. Neuropathol Appl Neurobiol 12:223–234
Gibb WRG (1988) The neuropathology of parkinsonian disorders. In: Jankovic J, Tososa E (eds) Parkinson's disease and movement disorders. Urban and Schwarzenberg, Baltimore, pp 205–223
Gibb WRG, Narabayashi H, Yokochi M, Iizuka R, Lees AJ (1991) New pathologic observations in juvenile onset parkinsonism with dystonia. Neurology 41:820–822
Gibb WRG, Scott T, Lee AJ (1991) Neuronal inclusions of Parkinson's disease. Mov Disord 6:2–11
Mizutani Y, Yokochi M, Oyanagi S (1991) Juvenile parkinsonism: A case report with neuropathological findings suggesting a new pathogenesis. Clin Neuropathol 10:91–97
Papolla MA, Shank DL, Alzofon J, Dudley AW (1988) Colloid(hyaline) inclusion bodies in the central nervous system: their presence in the substantia nigra is diagnostic of Parkinson's disease. Hum Pathol 19:27–31
Roy S, Wolmann L (1969) Ultrastructural observations in Parkinsonism. J Pathol 99:39–44
Watanabe I, Vachal E, Tomita T (1977) Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study. Acta Neuropathol (Berl) 39:173–175
Yagishita S, Itoh Y, Amano N, Nakano T (1980) Atypical senile dementia with widespread Lewy type inclusion in the cerebral cortex. Acta Neuropathol (Berl) 49:187–191
Yokochi M, Narabayashi H, Iizuka R, Nagatsu T (1984) Juvenile parkinsonism: some clinical, pharmacological, and neuropathological aspects. Adv Neurol 40:407–413
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Hayashida, K., Oyanagi, S., Mizutani, Y. et al. An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism. Acta Neuropathol 85, 445–448 (1993). https://doi.org/10.1007/BF00334457
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DOI: https://doi.org/10.1007/BF00334457