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Role of the CDC8 gene in the repair of single strand breaks in DNA of the yeast Saccharomyces cerevisiae

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It has been found that the repair of single strand breaks is defective in the DNA replication mutants cdc8-1 and cdc8-3 of Saccharomyces cerevisiae both in permissive (23°C) and restrictive conditions (36°C). In permissive conditions we observed a significant delay in single strand break repair in a diploid strain HB7 (cdc8-1/cdc8-1), as compared with the wild-type strain. Under restrictive conditions no repair was observed, but rather degradation of MMS-damaged DNA occurred. It has been also found that the repair of single strand breaks in yeast is inhibited by cycloheximide but not by hydroxyurea.

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Communicated by H. Bertrand

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Baranowska, H., Zaborowska, D., Jachymczyk, W.J. et al. Role of the CDC8 gene in the repair of single strand breaks in DNA of the yeast Saccharomyces cerevisiae . Curr Genet 18, 175–179 (1990). https://doi.org/10.1007/BF00318376

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  • DOI: https://doi.org/10.1007/BF00318376

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