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Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation

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Summary

Cryostat sections of 12 gliomas and of 3 peritumoral brain tissue samples were investigated for mononuclear cell infiltration by immunohistochemistry, concentrating on cells expressing monocyte/macrophage markers. Only low numbers of T cells were detected in the tumors, whereas in average 20%–30% of all cells present in the samples were recognized by various macrophage markers. These cells carried surface epitopes with known function, like Fc-γ (Fcg) and complement receptors. Microglial cells, in comparison to typical debris laden macrophages, were only recognized by a restricted panel of macrophages markers (anti-Fcg receptors 1, 2, 3, complement receptor CR3, HLA DR, common leucocyte antigen CD45 and the monocyte marker RM3/1). In peritumoral tissue mainly dendritic, microglia-like cells were present, which revealed decreased expression of antigens CD4, RM3/1 and Fcg receptors in comparison to those in gliomas. A significant positive correlation was found between the number of RM3/1 or CR3 (CD11b)-positive cells and the proliferation rate of the tumors as documented by the number of bromodeoxyuridine-positive or Ki-67+ cells.

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Author notes

  1. T. Morimura

    Present address: Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

Authors and Affiliations

  1. Neurologisches Institut, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria

    T. Morimura, C. Neuchrist, H. Budka & H. Lassmann

  2. Neurochirurgische Klinik, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria

    K. Kitz

  3. Institut für allgemeine und experimentelle Pathologie, Universität Wien, Schwarzspanierstrasse 17, A-1090, Wien, Austria

    O. Scheiner & D. Kraft

  4. Institut für Hirnforschung, Österreichische Akademie der Wissenschaften, Austria

    H. Lassmann

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Supported by Science Research Fund, Austria, Project P6438M and by the Anton-Dreher-Memorial Fund for Medical Research, Austria

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Morimura, T., Neuchrist, C., Kitz, K. et al. Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation. Acta Neuropathol 80, 287–294 (1990). https://doi.org/10.1007/BF00294647

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  • DOI: https://doi.org/10.1007/BF00294647

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