Abstract
Possible etiological factors of congenital malformations as well as of human trisomies are considered in the framework of the repressor hypothesis. In this approach gene expression is envisaged from the point of view of the functional variations of the total activation energy for normal gene expression in homeostatic equilibrium. We restrict our attention to variations of the total activation energy under the effect of temperature gradients. We discuss the evidence that hyperthermia may be an etiological factor for trisomies in humans.
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References
Ayala, F.J. and Kiger, J. (1984). Modern Genetics. 2nd ed.- Menlo Park, California: Benjamin/Cummings, pp. 720–721.
Chela-Flores, J. (1987). Towards a collective biology of the gene.- J. theor. Biol. 126: 127–136.
Clarren, S.K., Smith, D.W., Harvey, M.A., Ward, R.H. and Mynianthopoulos, N.C. (1979). Hyperthermia - a prospective evaluation of a possible teratogenic agent in man.- J. Pediatric 95: 81–83.
Coppen, A. and Cowie, V. (1960). Maternal health and mongolism.- Brit. Med. J. 1: 1843–1847.
Edwards, M.J. (1967). Congenital defects in Guinea pigs following induced hyperthermia during gestation.- Arch. Pathol. 84: 42.
Edwards, M.J. (1969). Congenital defects in Guinea pigs: Prenatal retardation of brain growth of Guinea pigs following hyperthermia during gestation.- Teratology 2: 329.
Ek, J.I. (1959). Thyroid function in mothers of mongoloid infants.- Acta Pediatr. 48: 33–41.
Fialkow, P.J., Hecht, F., Uchida, I.A. and Motulsky, A.G. (1965). Increased frequency of thyroid autoantibodies in mothers of patients with Down's syndrome.- Lancet 2: 868–870.
Fraser, F.C. and Skelton, J. (1978). Possible teratogenicity of maternal fever. Lancet 2: 634.
Hawe, P. and Harold, F. (1962). Pregnancy and thyrotoxicosis.- Brit. Med. J. 2: 817–822.
Herbst, A.L. and Selenkow, H.A. (1965). Hyperthyroidism during pregnancy.- New Eng. J. Med. 273: 627–633.
Miller, P., Smith, D.W. and Shepard, T.H. (1978). Maternal hyperthermia as a possible cause of anencephaly.- Lancet 1: 519–521.
Nilsson, C., Hansson, A. and Nilsson, G. (1975). Influence of thyroid hormones on satellite association in man and the origin of chromosome abnormalities.- Hereditas 80: 157–166.
Pleet, H., Graham, J.M. and Smith, D.W. (1981). Central nervous system and facial defects associated with maternal hyperthermia at 4 to 14 weeks' gestation. Pediatrics 67: 785–789.
Smith, D.W., Clarren, S.K. and Sedwick, M.A. (1978). Hyperthermia as a possible teratogenic agent.- J. Pediatric 92: 878–883.
Stern, J.H. (1983). Medicina Interna, Vol. 2.- Barcelona: Salvat. pp. 1830–1831.
van Wijck, J.A.M., Stolte, L.A.M., van Kessel, H.I.A.M. and Tijdink, G.A.J. (1961). A trisomic child of a hyperthyroid mother.- Lancet 1: 887–888.
Vogel, F. and Motulsky, A.G. (1986a). Human Genetics. Problems and Approaches. 2nd ed.- Berlin: Springer-Verlag, p. 345.
Vogel, F. and Motulsky, A.G. (1986b). Human Genetics. Problems and Approaches. 2nd ed.- Berlin: Springer-Verlag, p. 45–46.
Webster, W.S., Germain, M.A. and Edwards, M.J. (1985). The induction of microphthalmia, encephalocele, and other head defects following hyperthermia during the gastrulation process in the rat. Teratology 31: 73–82.
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Also at the Instituto Internacional de Estudios Avanzados Apartado 17606, Parque Central, Caracas 1015-A, Venezuela.
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Chela-Flores, J., Espejo Acuiña, C. On the possible effects of homeostatic shifts in human embryonic development. Acta Biotheor 38, 135–142 (1990). https://doi.org/10.1007/BF00047550
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DOI: https://doi.org/10.1007/BF00047550