Abstract
In a previous paper, we studied elementary models for polymerization, depolymerization, and fragmentation of actin filaments (Edelstein-Keshet and Ermentrout, 1998, Bull. Math. Biol. 60, 449–475). When these processes act together, more complicated dynamics occur. We concentrate on a particular case study, using the actin-fragmenting protein gelsolin. A set of biological parameter values (drawn from the experimental literature) is used in computer simulations of the kinetics of gelsolin-mediated actin filament fragmentation.
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Ermentrout, G.B., Edelstein-Keshet, L. Models for the length distributions of actin filaments: II. Polymerization and fragmentation by gelsolin acting together. Bull. Math. Biol. 60, 477–503 (1998). https://doi.org/10.1006/bulm.1997.0012
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DOI: https://doi.org/10.1006/bulm.1997.0012