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  • Conference proceedings
  • Open Access
  • © 2020

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

  • Discusses the latest concepts regarding the molecular mechanism of congenital heart disease

  • Includes contributions by an international group of distinguished scientists and clinicians

  • Highlights the latest research on pulmonary hypertension, with a focus on clinical implications and future directions

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Softcover Book USD 59.99
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Table of contents (65 papers)

  1. Front Matter

    Pages i-xiii
  2. Basic Science of Pulmonary Development and Pulmonary Arterial Disease

    1. Front Matter

      Pages 1-1
    2. Perspective for Part I

      • Hiroyuki Yamagishi
      Pages 3-5Open Access
    3. The Alveolar Stem Cell Niche of the Mammalian Lung

      • Brigid L. M. Hogan
      Pages 7-12Open Access
    4. Lung Development and Notch Signaling

      • Mitsuru Morimoto
      Pages 13-23Open Access
    5. Specialized Smooth Muscle Cell Progenitors in Pulmonary Hypertension

      • Fatima Zahra Saddouk, Aglaia Ntokou, Daniel M. Greif
      Pages 25-30Open Access
    6. Diverse Pharmacology of Prostacyclin Mimetics: Implications for Pulmonary Hypertension

      • Lucie H. Clapp, Jeries H. J. Abu-Hanna, Jigisha A. Patel
      Pages 31-61Open Access
    7. Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

      • Benoît Ranchoux, Virginie F. Tanguay, Frédéric Perros
      Pages 63-70Open Access
    8. Extracellular Vesicles, MicroRNAs, and Pulmonary Hypertension

      • Tianji Chen, J. Usha Raj
      Pages 71-77Open Access
    9. Roles of Tbx4 in the Lung Mesenchyme for Airway and Vascular Development

      • Keiko Uchida, Yu Yoshida, Kazuki Kodo, Hiroyuki Yamagishi
      Pages 79-81Open Access
    10. A lacZ Reporter Transgenic Mouse Line Revealing the Development of Pulmonary Artery

      • Reina Ishizaki, Keiko Uchida, Akimichi Shibata, Takatoshi Tsuchihashi, Jun Maeda, Katsuhiko Mikoshiba et al.
      Pages 83-85Open Access
    11. Roles of Stem Cell Antigen-1 in the Pulmonary Endothelium

      • Jun Maeda, Keiko Uchida, Kazuki Kodo, Hiroyuki Yamagishi
      Pages 87-89Open Access
    12. Morphological Characterization of Pulmonary Microvascular Disease in Bronchopulmonary Dysplasia Caused by Hyperoxia in Newborn Mice

      • Hidehiko Nakanishi, Shunichi Morikawa, Shuji Kitahara, Asuka Yoshii, Atsushi Uchiyama, Satoshi Kusuda et al.
      Pages 91-93Open Access
    13. Involvement of CXCR4 and Stem Cells in a Rat Model of Pulmonary Arterial Hypertension

      • Tingting Zhang, Nanako Kawaguchi, Emiko Hayama, Yoshiyuki Furutani, Toshio Nakanishi
      Pages 95-96Open Access
    14. Ca2+ Signal Through Inositol Trisphosphate Receptors for Cardiovascular Development and Pathophysiology of Pulmonary Arterial Hypertension

      • Akimichi Shibata, Keiko Uchida, Katsuhiko Mikoshiba, Hiroyuki Yamagishi
      Pages 97-99Open Access
  3. Abnormal Pulmonary Circulation in the Developing Lung and Heart

    1. Front Matter

      Pages 101-101
    2. Perspective for Part II

      • Toshio Nakanishi
      Pages 103-108Open Access
    3. Pathophysiology of Pulmonary Circulation in Congenital Heart Disease

      • Megumi Hashimoto, Masahiro Kaneko, Naohisa Nishida, Hina Serizawa, Kohei Kawata, Rika Sekiya et al.
      Pages 109-123Open Access

About this book

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Editors and Affiliations

  • Department of Pediatric Cardiology, Tokyo Women’s Medical University, Tokyo, Japan

    Toshio Nakanishi

  • Department of Pediatrics and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, USA

    H. Scott Baldwin

  • UCSF Benioff Children’s Hospital, University of California, San Francisco, USA

    Jeffrey R. Fineman

  • Division of Pediatric Cardiology, Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

    Hiroyuki Yamagishi

About the editors

Toshio Nakanishi

Tokyo Women's Medical University

Department of Pediatric Cardiology

Tokyo, Japan

nakanishi.toshio@twmu.ac.jp

 

Scott Baldwin

Vanderbilt University Medical Center

Department of Pediatrics (Cardiology) and Cell and Development Biology

Nashville

Tennessee, USA

scott.baldwin@Vanderbilt.Edu

 

Jeffrey Fineman

University of California

UCSF Benioff Children's Hospital

San Francisco

California, USA

Jeff.Fineman@ucsf.edu

 

Hiroyuki Yamagishi

Keio University School of Medicine

Department of Pediatrics

Shinjyuku-ku

Tokyo, Japan

hyamag@keio.jp



Bibliographic Information

  • Book Title: Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

  • Editors: Toshio Nakanishi, H. Scott Baldwin, Jeffrey R. Fineman, Hiroyuki Yamagishi

  • DOI: https://doi.org/10.1007/978-981-15-1185-1

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2020

  • License: CC BY

  • Hardcover ISBN: 978-981-15-1184-4Published: 29 February 2020

  • Softcover ISBN: 978-981-15-1187-5Published: 11 September 2020

  • eBook ISBN: 978-981-15-1185-1Published: 28 February 2020

  • Edition Number: 1

  • Number of Pages: XIII, 405

  • Number of Illustrations: 14 b/w illustrations, 74 illustrations in colour

  • Topics: Cardiology, Pediatrics

Buy it now

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 59.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access