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Atomic Force Microscopy in Molecular and Cell Biology

  • Book
  • © 2018

Overview

Editors:
  1. Jiye Cai

    1. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China

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  • Introduces the latest development of atomic force microscopy and related high techniques in the molecular and cell biology

  • Summarizes the new progress regarding high-resolution imaging for membrane structure and nanomechanical measurements for cell

  • Provides examples to illustrate how to achieve high resolution in AFM experiments

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Principles of Atomic Force Microscopy

    • Wanxin Sun
    Pages 1-28

  3. Atomic Force Microscopy-Based Single Molecule Force Spectroscopy for Biological Application

    • Chao Tang, Youjie Fan, Junhong Lü
    Pages 29-40

  4. In Situ Single Molecule Detection on Cell Membrane and Label Molecule Distributions Using AFM/NSOM

    • Jiang Pi, Hua Jin, Jiye Cai
    Pages 41-54

  5. AFM Imaging-Force Spectroscopy Combination for Molecular Recognition at the Single-Cell Level

    • Filomena A. Carvalho, Nuno C. Santos
    Pages 55-76

  6. Atomic Force Microscopy: A Nanoscopic Application in Molecular and Cell Biology

    • Huai-Hong Cai, Xueyi Zeng, Xiao Tang, Jiye Cai
    Pages 77-103

  7. The Hyphenated Technique of High Speed Atomic Force Microscopy and Super Resolution Optical Detection System

    • Xiao Feng, Yunchang Guo, Hongjie An, Hongshun Yang
    Pages 105-130

  8. AFM and NSOM/QD Based Direct Molecular Visualization at the Single-Cell Level

    • Liyun Zhong, Jiye Cai, Zhengwei Chen
    Pages 131-145

  9. Assessment of Pathological or Drug-Dependent Changes in Cell Membrane Morphology and Cell Biomechanical Properties by Atomic Force Microscopy

    • Hua Jin, Yue Zhao, Wandang Wang, Jinhuan Jiang, Jiye Cai, Colin E. Evans
    Pages 147-160

  10. In Situ Measuring Mechanical Properties of Normal and Disease Cells

    • Sui-Ping Deng, Yi-Li Yang, Xing-Xing Cheng, Wen-Rong Li, Jiye Cai
    Pages 161-178

  11. High Resolution AFM and Its Applications

    • Hao Sun, Ming Ye, Wanxin Sun
    Pages 179-235
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Keywords

About this book

The book addresses new achievements in AFM instruments – e.g. higher speed and higher resolution – and how AFM is being combined with other new methods like NSOM, STED, STORM, PALM, and Raman. This book explores the latest advances in atomic force microscopy and related techniques in molecular and cell biology. Atomic force microscopy (AFM) can be used to detect the superstructures of the cell membrane, cell morphology, cell skeletons and their mechanical properties.

Opening up new fields of in-situ dynamic study for living cells, enzymatic reactions, fibril growth and biomedical research, these combined techniques will yield valuable new insights into molecule and cell biology. This book offers a valuable resource for students and researchers in the fields of biochemistry, cell research and chemistry etc.

Editors and Affiliations

  • State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China

    Jiye Cai

About the editor

Dr. Jiye Cai is a Professor at Department of Chemistry, Jinan University, Guangzhou, China

Bibliographic Information

  • Book Title: Atomic Force Microscopy in Molecular and Cell Biology

  • Editors: Jiye Cai

  • DOI: https://doi.org/10.1007/978-981-13-1510-7

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2018

  • Hardcover ISBN: 978-981-13-1509-1Published: 15 November 2018

  • eBook ISBN: 978-981-13-1510-7Published: 03 November 2018

  • Edition Number: 1

  • Number of Pages: XIII, 235

  • Number of Illustrations: 27 b/w illustrations, 109 illustrations in colour

  • Topics: Biochemistry, general, Biomedical Engineering/Biotechnology

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