Radiation Oncology: Radiobiological and Physiological Perspectives

1. Front Matter

   Pages i-xiii

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2. Development of Radiation Damage from the Initial Physical Events to the Expression of the Clinical Response

   1. Front Matter

      Pages 1-1

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   2. The Overall Radiobiological Effect: The Evolution of Radiation Damage

      • Hassan K. Awwad

      Pages 3-15

3. Measurement of Reproductive Cell Death Modification of the Radiation-Response by Some Intrinsic and Extrinsic Factors

   1. Front Matter

      Pages 17-17

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   2. Dose Survival Relationships: Methodology, Forms, and Interpretations

      • Hassan K. Awwad

      Pages 19-52

   3. Some Modifiers of Dose-Response Relationships

      • Hassan K. Awwad

      Pages 53-83

   4. Interaction of Radiation and Chemotherapeutic Agents

      • Hassan K. Awwad

      Pages 85-106

4. Radiation-Induced Normal Tissue Damage : General Principles and Specific Examples

   1. Front Matter

      Pages 107-107

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   2. Radiation Effects on Normal Tissues: General Principles

      • Hassan K. Awwad

      Pages 109-127

   3. Dose-Time-Volume Relationships in Normal Tissue Response to Irradiation

      • Hassan K. Awwad

      Pages 129-187

   4. Early Reacting Tissues: Skin

      • Hassan K. Awwad

      Pages 189-221

   5. Early Reacting Tissues: The Haematopoietic Tissue

      • Hassan K. Awwad

      Pages 223-246

   6. Early Reacting Tissues: The Lymphoid Tissue and the Immune System

      • Hassan K. Awwad

      Pages 247-290

   7. Early Reacting Tissues: The Digestive Tract

      • Hassan K. Awwad

      Pages 291-322

   8. Early Reacting Tissues: The Testes

      • Hassan K. Awwad

      Pages 323-344

   9. Radiation Effects on the Ovary: A Nonrenewal System

      • Hassan K. Awwad

      Pages 345-356

   10. Late Reacting Tissues: Radiation-Induced Lung Damage

       • Hassan K. Awwad

       Pages 357-393

   11. Late Reacting Tissues: The Urinary Tract

       • Hassan K. Awwad

       Pages 395-420

   12. Late Reacting Normal Tissues: Radiation-Induced Liver Damage

       • Hassan K. Awwad

       Pages 421-427

   13. Late Reacting Tissues: Radiation-Induced Damage to the Central Nervous System

       • Hassan K. Awwad

       Pages 429-447

During the past four decades knowledge about biological effects of ionizing radiations on mammalian cells, normal tissues and tumours has increased enormously and has enabled radiotherapists to obtain a better insight into the advantages and disadvantages of cancer treatments with modified regimens of irradiations and combinations with chemotherapeutic agents. Even for the older scientists and clinicians who have wit­ nessed all these developments and have contributed to the vast amount of information, it is difficult to integrate this knowledge and to apply it in their daily work. For younger workers it is often difficult to select the important main concepts and results from the overwhelming number of publications. It is evident that a book which provides an integrated view of basic and applied radiation oncology can be of great value to students, scientists and, most importantly, to clinicians who can devote only part of their time to the task of understanding the radiobiological background of their application of radiation in cancer treatment. This book "Radiation Oncology" is written by a radiotherapist who has for a long time participated in the integration of basic knowledge and clinical experience. He has selected radiobiological information which is considered important to radiotherapy and in the description and interpretation of normal tissue tolerance and tumour eradication probability, he illustrates how basic knowledge can be applied clinically.

• liver
• radiation
• radiation damage
• radiation oncology
• radiobiology
• radiotherapy
• tumor
• Radiaton Oncology
• Diagnostic Radiology

• National Cancer Institute, University of Cairo, Cairo, Egypt

  Hassan K. Awwad

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