Immunochemistry in Clinical Laboratory Medicine

1. Front Matter

   Pages i-xi

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2. Methods and Problems in Immunochemistry

   1. Front Matter

      Pages 1-1

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   2. Electrophoresis and Immunoelectrophoresis

      • Pamela G. Riches

      Pages 3-15

   3. Radial immunodiffusion and rocket Immunoelectrophoresis

      • D. Kenny

      Pages 17-22

   4. Automated immunoprecipitation and laser nephelometry

      • P. A. E. White, R. Strong

      Pages 23-33

   5. Antiserum requirements

      • A. C. Munro

      Pages 35-49

   6. Problems encountered in immunochemical technique methodology

      • J. T. Whicher

      Pages 51-61

   7. Specific protein measurement and standardization

      • R. S. Wainwright, J. R. Doggart, D. W. Neill

      Pages 63-73

   8. Quality control

      • D. M. Browning

      Pages 75-81

3. Specific Proteins in Laboratory Diagnosis

   1. Front Matter

      Pages 83-83

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   2. Structure and function of the immunoglobulins

      • R. S. H. Pumphrey

      Pages 85-97

   3. Immunoglobulins in blood transfusion

      • P. D. J. Holt

      Pages 99-113

   4. Monoclonal proteins

      • J. Kohn

      Pages 115-126

   5. Iron binding proteins

      • A. Jacobs

      Pages 127-133

   6. Albumin

      • Linda Smith

      Pages 135-148

   7. The complement system

      • J. T. Whicher

      Pages 149-163

   8. Alphafetoprotein in obstetrics

      • D. J. H. Brock

      Pages 165-176

   9. Alphafetoprotein in oncology

      • J. Kohn

      Pages 177-182

   10. α1-Antitrypsin

       • A. Milford Ward

       Pages 183-195

   11. Haptoglobin and orosomucoid in lung and breast tumours

       • A. R. Bradwell

       Pages 197-215

The rapid growth of specific protein estimations in the clinical laboratory over the last 10 years has been due to advances both in methodology and in the understanding of the role of the various plasma proteins in health and disease. This expansion has been made possible by the development of both gel phase and fluid phase techniques for the estimation of proteins and the ready availability of antisera to individual plasma proteins. The specificity of the immunological reaction has allowed the more precise identification and estimation of individual plasma proteins than was possible with dye binding or other chemical techniques, but at the same time these methods have introduced other possible errors and pitfalls. Advances in understanding of the structure and function of various plasma proteins has pointed the way to new clinical applications of plasma protein estimation in the diagnosis and monitoring of disease. The Symposium, of which these are the proceedings, was planned to bring together a number of experts in the field to discuss the available methods and their clinical application.

• blood
• chemistry
• clinical application
• development
• diagnosis
• growth
• health
• immunoglobulin
• lung
• monitoring
• protein
• proteins
• quality
• quality control
• standardization

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