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Minimal Residual Disease in Acute Leukemia 1986

  • Book
  • © 1986

Overview

Editors:
  1. Anton Hagenbeek

    1. The Dr. Daniël den Hoed Cancer Center, Rotterdam, The Netherlands
      Radiobiological Institute TNO, Rijswijk, The Netherlands

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  2. Bob Löwenberg

    1. The Dr. Daniël den Hoed Cancer Center, Rotterdam, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Oncology (DION, volume 45)

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Table of contents (36 chapters)

  1. Front Matter

    Pages I-XIV
    Download chapter PDF

  2. Detection of Minimal Residual Disease in Acute Leukemia

    1. New Possibilities for Cytogenetic Analysis of Leukemic Cells

      • A. Hagemeijer, H. J. Adriaansen, C. R. Bartram
      Pages 1-11

    2. Breakpoint Analysis in CML: Potentials for Detection of Minimal Residual Disease

      • G. C. Grosveld, D. Bootsma, A. de Klein, N. Heisterkamp, K. Stam, J. Groffen
      Pages 12-22

    3. The Mammalian ETS Genes: Two Unique Chromosomal Locations in Cat, Mice and Man and Novel Translocated Position in Human Leukemias

      • T. S. Papas, D. K. Watson, N. Sacchi, S. J. O’Brien, R. Ascione
      Pages 23-42

    4. Activated RAS Oncogenes in Acute Leukemia

      • J. L. Bos, M. Verlaan-de Vries, A. J. van der Eb, R. Delwel, B. Löwenberg, S. J. Roodenhuis et al.
      Pages 43-50

    5. DNA Rearrangements as Unique Markers of Clonal Evolution, Recurrence and Translocation

      • J. J. Wright, D. G. Poplack, A. Bakhshi, S. J. Korsmeyer
      Pages 51-57

    6. The application of monoclonal antibodies for the detection and classification of AML

      • James D. Griffin
      Pages 58-67

    7. Towards Detection of Minimal Disease: Discrimination of AML Precursors from Normal Myeloid Precursors using a Combination of Surface Markers

      • Ruud Delwel, Ivo Touw, Bob Löwenberg
      Pages 68-75

    8. An Immunological Approach to Analyse the Kinetics of Minimal Residual Disease in Acute Leukemia

      • Anton Hagenbeek, Anton C. M. Martens
      Pages 76-85

    9. Visualization of Minor Cell Populations with Simultaneous Three-Parameter Flow Cytometry: BN Rat Marrow and Spleen Model

      • Arthur K. Sullivan, Alan Brox, Gerald Price
      Pages 86-96

    10. Growth Kinetics of Minimal Residual Disease in the Brown Norway Rat Acute Myelocytic Leukemia

      • F. W. Schultz, A. C. M. Martens, A. Hagenbeek
      Pages 97-111

    11. Detection of Minimal Residual Acute Lymphoblastic Leukemia by Immunological Marker Analysis: Possibilities and Limitations

      • J. J. M. van Dongen, H. Hooijkaas, H. J. Adriaansen, K. Hahlen, G. E. van Zanen
      Pages 113-133

    12. Surveillance of Terminal Deoxynucleotidyl Transferase-Positive Cells in Peripheral Blood of Patients with Acute Lymphoblastic Leukemia

      • R. G. Smith, M. L. Hetherington, P. R. Huntsman, G. R. Buchanan
      Pages 134-140

    13. In Vitro Colony Forming Cells of Acute Lymphoblastic Leukemia: Analysis of 24 Cases with Recombinant Interleukin 2 as Growth Stimulus

      • Ivo Touw, Willem Hofhuis, George van Zanen, Ruud Delwel, Bob Lowenberg
      Pages 141-147

  3. Intensive Chemotherapy Regimens for ‘Minimal Residual Disease’ in Acute Myeloblastic and Lymphoblastic Leukemia

    1. Biologic and Treatment Determinants of Curability in Acute Myelogenous Leukemia

      • Michael J. Keating, Kenneth B. McCredie, Emil J. Freireich
      Pages 148-158

    2. High-Dose Cytosine-Arabinoside Plus AMSA for Reinduction or Consolidation-Maintenance in Acute Myelogenous Leukemia

      • R. Zittoun
      Pages 159-166

    3. Treatment of Residual Disease in AML: Interim Analysis of a Southeastern Cancer Study Group Prospective Randomized Clinical Trial

      • Roy S. Weiner, Marilyn Raney, Gerald J. Elfenbein, Barnett S. Kramer, W. Ralph Vogler, Elliott F. Winton et al.
      Pages 167-179

    4. L-20 Protocol for Adult Patients with Acute Lymphoblastic Leukemia: A Protocol Utilizing Prognostic Factors, Intensive Chemotherapy and Autologous “Purged” Marrow Transplantation to Eradicate Minimal Residual Disease

      • T. Gee, S. Gulati, B. D. Clarkson
      Pages 180-195

    5. Treatment of Minimal Residual Disease in Adult ALL: The German National Study

      • D. Hoelzer, E. Thiel, H. Löffler, Th. Büchner, D. Bodenstein, R. Engelhardt et al.
      Pages 196-204

    6. Treatment of Minimal Residual Disease in “Poor Risk” Acute Lymphoblastic Leukaemia with High-Dose Cytosine Arabinoside

      • M. J. Barnett, J. E. Kingston, A. Miller, A. Z. S. Rohatiner, M. A. Horton, M. F. Greaves et al.
      Pages 205-210
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Keywords

About this book

Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia. Leukemia recurs most frequently in patients with acute myeloblastic leukemia (AML) and high risk acute lymphoblastic leukemia (ALL) following chemotherapy and less often in patients with low risk ALL and particularly in patient groups> submitted to allogeneic marrow transplantation. ' It is likely that the great majority of these recurrences originate from residual leukemic cells that survive initial remission-induction chemotherapy. Today, several research groups throughout the world place emphasis on studies concerned with the detection and treatment of 'minimal residual disease' (MRD). These investigations are conducted with the common objective to tackle the remaining cells. 'Minimal Residual Disease in Acute Leukemia: 1986' summarizes the fast advancements in this area. Several disciplines are concerned with the analysis of leukemic cells. The perspectives of cytogenetic and molecular genetic approaches for applica­ tion in the detection of MRD are reviewed. In this respect, modern cyto­ genetics provide highly specific tumor markers. The resolution of cyto­ genetic methods can be particularly improved when combined with other techniques which select relevant subpopulations of cells. Characterization of oncogenes and gene rearrangements, including those of immunoglobulin and T-cell receptor genes, and the measurement of gene products, have been established. Techniques based on these approaches offer interesting tools for the detection of MRD. New possibilities of employing monoclonal anti­ bodies are also presented.

Editors and Affiliations

  • The Dr. Daniël den Hoed Cancer Center, Rotterdam, The Netherlands

    Anton Hagenbeek, Bob Löwenberg

  • Radiobiological Institute TNO, Rijswijk, The Netherlands

    Anton Hagenbeek

Bibliographic Information

  • Book Title: Minimal Residual Disease in Acute Leukemia 1986

  • Editors: Anton Hagenbeek, Bob Löwenberg

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-94-009-4273-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, Dordrecht 1986

  • Hardcover ISBN: 978-0-89838-799-5Published: 31 March 1986

  • Softcover ISBN: 978-94-010-8398-0Published: 03 November 2011

  • eBook ISBN: 978-94-009-4273-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 393

  • Topics: Oncology, Hematology

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