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Stereochemical Analysis of Alicyclic Compounds by C-13 NMR Spectroscopy

  • Book
  • © 1987

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Authors:
  1. James K. Whitesell
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  2. Mark A. Minton
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Table of contents (19 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Introduction

    • James K. Whitesell, Mark A. Minton
    Pages 1-2

  3. Fundamental Effects on Carbon Shifts

    • James K. Whitesell, Mark A. Minton
    Pages 3-9

  4. Mono- and Bicyclic Systems

    • James K. Whitesell, Mark A. Minton
    Pages 11-35

  5. Stereochemical Considerations

    • James K. Whitesell, Mark A. Minton
    Pages 37-44

  6. Multiple Substituent Shift Additivity

    • James K. Whitesell, Mark A. Minton
    Pages 45-54

  7. Bicyclo[2.2.1]heptanes

    • James K. Whitesell, Mark A. Minton
    Pages 55-92

  8. Bicyclo[2.2.2]octanes

    • James K. Whitesell, Mark A. Minton
    Pages 93-105

  9. Bicyclo[3.1.0]hexanes

    • James K. Whitesell, Mark A. Minton
    Pages 107-111

  10. Bicyclo[3.1.1]heptanes

    • James K. Whitesell, Mark A. Minton
    Pages 113-117

  11. Bicyclo[3.2.0]heptanes

    • James K. Whitesell, Mark A. Minton
    Pages 119-121

  12. Bicyclo[3.2.1]octanes

    • James K. Whitesell, Mark A. Minton
    Pages 123-132

  13. Bicyclo[3.2.2]nonanes

    • James K. Whitesell, Mark A. Minton
    Pages 133-135

  14. Bicyclo[3.3.0]octanes

    • James K. Whitesell, Mark A. Minton
    Pages 137-150

  15. Bicyclo[3.3.1]nonanes and Tricyclo[3.3.1.13,7]decanes

    • James K. Whitesell, Mark A. Minton
    Pages 151-177

  16. Bicyclo[4.1.0]heptanes

    • James K. Whitesell, Mark A. Minton
    Pages 179-187

  17. Bicyclo[4.2.0]octanes

    • James K. Whitesell, Mark A. Minton
    Pages 189-191

  18. Bicyclo[4.3.0]nonanes

    • James K. Whitesell, Mark A. Minton
    Pages 193-203

  19. Bicyclo[4.4.0]decanes

    • James K. Whitesell, Mark A. Minton
    Pages 205-224

  20. Spirocyclics

    • James K. Whitesell, Mark A. Minton
    Pages 225-231
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Keywords

About this book

Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.

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