Reprogramming Microbial Metabolic Pathways

1. Front Matter

   Pages i-xiv

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2. Emerging Methods for Redesigning Microorganisms

   1. Front Matter

      Pages 1-1

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   2. Towards Synthetic Gene Circuits with Enhancers: Biology’s Multi-input Integrators

      • Roee Amit

      Pages 3-20

   3. Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways

      • Cong T. Trinh, R. Adam Thompson

      Pages 21-42

   4. Evolutionary Engineering for Industrial Microbiology

      • Niti Vanee, Adam B. Fisher, Stephen S. Fong

      Pages 43-71

   5. Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches

      • Joshua T. Ellis, Ronald C. Sims, Charles D. Miller

      Pages 73-94

   6. Synthetic Biology Triggers New Era of Antibiotics Development

      • Jianfeng Wang, Zhiqiang Xiong, Hailin Meng, Yiguang Wang, Yong Wang

      Pages 95-114

   7. Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis

      • Juan F. Martín, Paloma Liras

      Pages 115-138

   8. Systems Analysis of Microbial Adaptations to Simultaneous Stresses

      • Ross P. Carlson, Olusegun J. Oshota, Reed L. Taffs

      Pages 139-157

   9. Metabolic Reprogramming Under Microaerobic and Anaerobic Conditions in Bacteria

      • Yue Shan, Yong Lai, Aixin Yan

      Pages 159-179

   10. Tunable Promoters in Synthetic and Systems Biology

       • Tore Dehli, Christian Solem, Peter Ruhdal Jensen

       Pages 181-201

   11. Analysis of Corynebacterium glutamicum Promoters and Their Applications

       • Jan Nešvera, Jiří Holátko, Miroslav Pátek

       Pages 203-221

3. Metabolic Engineering for Overproducing Chemicals and Materials

   1. Front Matter

      Pages 223-223

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4. Metabolic Engineering for Overproducing Chemicals and Materials

   1. Production of Fumaric Acid by Fermentation

      • Adrie J. J. Straathof, Walter M. van Gulik

      Pages 225-240

   2. Metabolic Engineering of Microorganisms for Vitamin C Production

      • Jingwen Zhou, Guocheng Du, Jian Chen

      Pages 241-259

   3. Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum

      • Takashi Hirasawa, Jongpill Kim, Tomokazu Shirai, Chikara Furusawa, Hiroshi Shimizu

      Pages 261-281

   4. Microbial Metabolic Engineering for L-Threonine Production

      • Xunyan Dong, Peter J. Quinn, Xiaoyuan Wang

      Pages 283-302

   5. The Production of Coenzyme Q10 in Microorganisms

      • Corinne P. Cluis, Dominic Pinel, Vincent J. Martin

      Pages 303-326

   6. Genetic Modification and Bioprocess Optimization for S-Adenosyl-L-methionine Biosynthesis

      • Xiaoqing Hu, Peter J. Quinn, Zhou Wang, Guoqiang Han, Xiaoyuan Wang

      Pages 327-341

   7. Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-Based Products

      • Christopher J. Brigham, Natalia Zhila, Ekaterina Shishatskaya, Tatiana G. Volova, Anthony J. Sinskey

      Pages 343-366

Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

• Fermentation
• Industrial microbes
• Metabolic engineering
• Microbial Metabolic pathways
• Reprogramming microorganisms
• Systems Biology
• Metabolomics

• , State Key Laboratory, Jiangnan University, Wuxi, China, People's Republic

  Xiaoyuan Wang

• School of Biotechnology, Jiangnan University, Wuxi, China, People's Republic

  Jian Chen

• , Div. of Life Sciences, King's College London, London, United Kingdom

  Peter Quinn

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