Authors:
- A unique and comprehensive survey and description of diseases, the chaperonopathies, in which molecular chaperones are etiologic-pathogenic factors
- An easy-to-grasp, well-illustrated with tables and figures, panoramic view of the state-of-the-art analysis of chaperonopathies
- Unveils new routes to diagnose chaperonopathies, establish prognosis, treat and manage patients properly, thereby showing the path for future research
Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology (BRIEFSBIOCHEM)
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Table of contents (9 chapters)
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Front Matter
About this book
This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.Â
Authors and Affiliations
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School of Medicine, Dept. of Microbiology and Immunology, University of Maryland, Baltimore, USA
Alberto J.L. Macario
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Biotechnology Inst., Department of Microbiology and Immunolog, University of Maryland, Baltimore, USA
Everly Conway de Macario
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, Department of Experimental Biomedicine, University of Palermo, Palermo, Italy
Francesco Cappello
Bibliographic Information
Book Title: The Chaperonopathies
Book Subtitle: Diseases with Defective Molecular Chaperones
Authors: Alberto J.L. Macario, Everly Conway de Macario, Francesco Cappello
Series Title: SpringerBriefs in Biochemistry and Molecular Biology
DOI: https://doi.org/10.1007/978-94-007-4667-1
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Author(s) 2013
Softcover ISBN: 978-94-007-4666-4Published: 26 April 2013
eBook ISBN: 978-94-007-4667-1Published: 10 April 2013
Series ISSN: 2211-9353
Series E-ISSN: 2211-9361
Edition Number: 1
Number of Pages: XVI, 116
Number of Illustrations: 3 b/w illustrations, 23 illustrations in colour
Topics: Biomedicine general, Biochemistry, general, Protein Science