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The Eukaryotic Replisome: a Guide to Protein Structure and Function

  • Book
  • © 2012

Overview

Editors:
  1. Stuart MacNeill

    1. , School of Biology, University of St Andrews, St Andrews, United Kingdom

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  • Takes the reader on a guided tour of the structural biology of the eukaryotic DNA replication machinery, the first time that this has been done in a single volume
  • Individual chapters focusing on the three-dimensional structure and function of key components written by leading experts in the field
  • An additional chapter providing a comprehensive overview of the evolutionary distribution of key proteins and protein complexes.

Part of the book series: Subcellular Biochemistry (SCBI, volume 62)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Composition and Dynamics of the Eukaryotic Replisome: A Brief Overview

    • Stuart MacNeill
    Pages 1-17

  3. Evolutionary Diversification of Eukaryotic DNA Replication Machinery

    • Stephen J. Aves, Yuan Liu, Thomas A. Richards
    Pages 19-35

  4. The Origin Recognition Complex: A Biochemical and Structural View

    • Huilin Li, Bruce Stillman
    Pages 37-58

  5. Archaeal Orc1/Cdc6 Proteins

    • Stephen D. Bell
    Pages 59-69

  6. Cdt1 and Geminin in DNA Replication Initiation

    • Christophe Caillat, Anastassis Perrakis
    Pages 71-87

  7. MCM Structure and Mechanics: What We Have Learned from Archaeal MCM

    • Ian M. Slaymaker, Xiaojiang S. Chen
    Pages 89-111

  8. The Eukaryotic Mcm2-7 Replicative Helicase

    • Sriram Vijayraghavan, Anthony Schwacha
    Pages 113-134

  9. The GINS Complex: Structure and Function

    • Katsuhiko Kamada
    Pages 135-156

  10. The Pol α-Primase Complex

    • Luca Pellegrini
    Pages 157-169

  11. The Structure and Function of Replication Protein A in DNA Replication

    • Aishwarya Prakash, Gloria E. O. Borgstahl
    Pages 171-196

  12. Structural Biology of Replication Initiation Factor Mcm10

    • Wenyue Du, Melissa E. Stauffer, Brandt F. Eichman
    Pages 197-216

  13. Structure and Function of Eukaryotic DNA Polymerase δ

    • Tahir H. Tahirov
    Pages 217-236

  14. DNA Polymerase ε

    • Matthew Hogg, Erik Johansson
    Pages 237-257

  15. The RFC Clamp Loader: Structure and Function

    • Nina Y. Yao, Mike O’Donnell
    Pages 259-279

  16. PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA

    • Lynne M. Dieckman, Bret D. Freudenthal, M. Todd Washington
    Pages 281-299

  17. The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation

    • L. David Finger, John M. Atack, Susan Tsutakawa, Scott Classen, John Tainer, Jane Grasby et al.
    Pages 301-326

  18. DNA Ligase I, the Replicative DNA Ligase

    • Timothy R. L. Howes, Alan E. Tomkinson
    Pages 327-341

  19. Back Matter

    Pages 343-345
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Keywords

About this book

High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

Editors and Affiliations

  • , School of Biology, University of St Andrews, St Andrews, United Kingdom

    Stuart MacNeill

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