Stem Cells and Human Diseases

1. Front Matter

   Pages i-ix

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2. Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications

   • Brahma N. Singh, Sharmila Shankar, Rakesh K. Srivastava

   Pages 1-22

3. The Perspectives of Stem Cell-Based Therapy in Neurological Diseases

   • Wojciech Maksymowicz, Joanna Wojtkiewicz, Hanna Kozłowska, Aleksandra Habich, Wlodek Lopaczynski

   Pages 23-60

4. Stem Cell-Based Therapy for Lysosomal Storage Diseases

   • Brittni A. Scruggs, Xiujuan Zhang, Jeffrey M. Gimble, Bruce A. Bunnell

   Pages 61-90

5. Drosophila Germline Stem Cells

   • Yalan Xing, Willis X. Li

   Pages 91-99

6. Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation

   • Peiman Hematti, Jaehyup Kim, Minoo Battiwalla

   Pages 101-115

7. Cancer Stem Cells in Solid Tumors, Markers and Therapy

   • Ortiz-Sánchez Elizabeth, González-Montoya José Luis, Langley Elizabeth, García-Carrancá Alejandro

   Pages 117-148

8. Cancer Stem Cells: Paradigm Shifting or Perishing Concept?

   • Senthil K. Pazhanisamy, Keith Syson Chan

   Pages 149-174

9. Genomics of Prostate Cancer

   • Kern Rei Chng, Shin Chet Chuah, Edwin Cheung

   Pages 175-196

10. Ischemia, Reactive Radicals, Redox Signaling and Hematopoietic Stem Cells

    • Suman Kanji, Vincent J. Pompili, Hiranmoy Das

    Pages 197-216

11. Cancer Stem Cell Models and Role in Drug Discovery

    • Rohit Duggal, Boris Minev, Angelo Vescovi, Aladar Szalay

    Pages 217-228

12. Origins of Metastasis-Initiating Cells

    • Sara M. Nolte, Sheila K. Singh

    Pages 229-246

13. The Reduction of Callus Formation During Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells

    • Claudia Keibl, Martijn van Griensven

    Pages 247-266

14. Stem Cells and Leukemia

    • Vincenzo Giambra, Christopher R. Jenkins

    Pages 267-306

15. The Role of Adult Bone Marrow Derived Mesenchymal Stem Cells, Growth Factors and Scaffolds in the Repair of Cartilage and Bone

    • Antal Salamon, Erzsébet Toldy

    Pages 307-322

16. Worth the Weight: Adipose Stem Cells in Human Disease

    • Saleh Heneidi, Gregorio Chazenbalk

    Pages 323-351

17. Neural Crest and Hirschsprung’s Disease

    • Kim Hei-Man Chow, Paul Kwong-Hang Tam, Elly Sau-Wai Ngan

    Pages 353-386

18. Common Denominators of Self-renewal and Malignancy in Neural Stem Cells and Glioma

    • Grzegorz Wicher, Karin Holmqvist, Karin Forsberg-Nilsson

    Pages 387-418

19. Stem-Like Cells from Brain Tumours or Vice Versa?

    • Sara G. M. Piccirillo

    Pages 419-431

20. Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics

    • Rajneesh Pathania, Vadivel Ganapathy, Muthusamy Thangaraju

    Pages 433-450

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

• Cancer Stem Cells
• Drug Resistance
• Physiology and Metabolisms
• Stem Cells
• microRNA
• Entomology

• , Pharmacology and Toxicology, University of Kansas Medical Center, Kansas City, USA

  Rakesh Srivastava

• , Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA

  Sharmila Shankar

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