Overview
Buy print copy
Tax calculation will be finalised at checkout
Table of contents (7 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
The success of the early nucleoside agents, the toxicity and metabolic instability of many nucleoside analogues, and the effects of viral pathogens on public health are driving the design, synthesis and evaluation of new nucleoside analogues, with much attention turning to nucleosides containing `non natural' sugar analogues. This book focuses on the development of these agents, and draws together all the available material in an easily consulted form, which at the same time guides the reader into the research literature on the subject. Written primarily for the medicinal chemist, coverage includes both synthetic strategies and outline guidance on the main trends in biological activity. Particular attention is drawn to the comparison of synthetic routes to compounds with their natural analogues. Finally, the important antiviral activities of the compounds are treated, including anti-retrovirus, anti-hepadnavirus and anti-herpes virus properties.
Written mainly for medicinal chemists in the pharmaceutical industry and synthetic organic chemists in academe, this book will also be attractive to researchers in institutions focusing on cellular metabolism. Advanced students of organic chemistry will find the clear discussion of the synthetic strategies adopted in the development of these compounds a useful introduction to this exciting and challenging area.
Authors and Affiliations
Bibliographic Information
Book Title: Acyclic, Carbocyclic and L-Nucleosides
Authors: L. A. Agrofoglio, S. R. Challand
DOI: https://doi.org/10.1007/978-94-007-0816-7
Publisher: Springer Dordrecht
-
eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 1998
Hardcover ISBN: 978-0-7514-0434-0Published: 31 October 1998
Softcover ISBN: 978-94-010-3734-1Published: 07 September 2012
eBook ISBN: 978-94-007-0816-7Published: 08 September 2012
Edition Number: 1
Number of Pages: X, 383
Topics: Bioorganic Chemistry, Organic Chemistry, Industrial Chemistry/Chemical Engineering, Pharmacy