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Magnetic Resonance Spectroscopy in Multiple Sclerosis

  • Book
  • © 2001

Overview

Editors:
  1. Massimo Filippi

    1. Neuroimaging Research Unit, Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

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  2. Douglas L. Arnold

    1. Magnetic Resonance Spectroscopy Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Canada

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  3. Giancarlo Comi

    1. Clinical Trials Unit, Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

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  • Magnetic resonance spectroscopy is a new, very promising method to understand the MS process
  • The book underlines how new technology can help to understand old diseases

Part of the book series: Topics in Neuroscience (TOPNEURO)

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-XII
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  2. Introduction

    • M. Filippi, D. L. Arnold, G. Comi
    Pages 1-4

  3. Axonal Signals and Central Nervous System Myelination

    • C. Lubetzki, B. Zalc
    Pages 5-13

  4. Axonal Loss in Multiple Sclerosis

    • C. Bjartmar, B. D. Trapp
    Pages 15-32

  5. Magnetic Resonance Spectroscopy: Fundamentals

    • J. C. McGowan
    Pages 33-49

  6. Magnetic Resonance Spectroscopy in Experimental Allergic Encephalomyelitis

    • S. P. Morrissey
    Pages 51-59

  7. Axonal Injury and Disability in Multiple Sclerosis: Magnetic Resonance Spectroscopy as a Measure of Dynamic Pathological Change in White Matter

    • D. L. Arnold, N. De Stefano, S. Narayanan, P. M. Matthews
    Pages 61-67

  8. Functional Magnetic Resonance Imaging and Multiple Sclerosis: Cortical Reorganisation and Recovery

    • H. Reddy, D. L. Arnold, P. M. Matthews
    Pages 69-77

  9. Correlations between Magnetic Resonance Spectroscopy and Other Magnetic Resonance Parameters in Multiple Sclerosis

    • M. Rovaris, M. Filippi
    Pages 79-86

  10. Magnetization Transfer and Diffusion-Weighted Magnetic Resonance Imaging in Multiple Sclerosis and Other White Matter Diseases

    • M. Filippi, G. Comi
    Pages 87-96

  11. New Magnetic Resonance Spectroscopy Strategies

    • O. Gonen, R. I. Grossman
    Pages 97-112

  12. Optimization and Standardization of Magnetic Resonance Spectroscopy Techniques for Multicenter Longitudinal Multiple Sclerosis Studies

    • J. C. McGowan
    Pages 113-119

  13. Overview of Magnetic Resonance Spectroscopy Studies in White Matter Diseases Other than Multiple Sclerosis

    • N. De Stefano, A. Federico
    Pages 121-133

  14. Overview of Magnetic Resonance Studies in Other Neurological Conditions

    • A. Falini
    Pages 135-147

  15. Back Matter

    Pages 149-153
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Keywords

About this book

Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".

Editors and Affiliations

  • Neuroimaging Research Unit, Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

    Massimo Filippi

  • Magnetic Resonance Spectroscopy Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Canada

    Douglas L. Arnold

  • Clinical Trials Unit, Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

    Giancarlo Comi

Bibliographic Information

  • Book Title: Magnetic Resonance Spectroscopy in Multiple Sclerosis

  • Editors: Massimo Filippi, Douglas L. Arnold, Giancarlo Comi

  • Series Title: Topics in Neuroscience

  • DOI: https://doi.org/10.1007/978-88-470-2109-9

  • Publisher: Springer Milano

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Italia 2001

  • Hardcover ISBN: 978-88-470-0123-7Published: 01 December 2000

  • Softcover ISBN: 978-88-470-2164-8Published: 23 October 2012

  • eBook ISBN: 978-88-470-2109-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 153

  • Topics: Neuroradiology, Neurology

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