Systems Biology Application in Synthetic Biology

1. Front Matter

   Pages i-xi

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2. Microbial Chassis Assisting Retrosynthesis

   • Milsee Mol, Vineetha Mandlik, Shailza Singh

   Pages 1-10

3. Computational Proteomics

   • Debasree Sarkar, Sudipto Saha

   Pages 11-20

4. Design, Principles, Network Architecture and Their Analysis Strategies as Applied to Biological Systems

   • Ahmad Abu Turab Naqvi, Md. Imtaiyaz Hassan

   Pages 21-31

5. Structureomics in Systems-Based Drug Discovery

   • Lumbini R. Yadav, Pankaj Thapa, Lipi Das, Ashok K. Varma

   Pages 33-51

6. Biosensors for Metabolic Engineering

   • Qiang Yan, Stephen S. Fong

   Pages 53-70

7. Sustainable Assessment on Using Bacterial Platform to Produce High-Added-Value Products from Berries through Metabolic Engineering

   • Lei Pei, Markus Schmidt

   Pages 71-78

8. Hindrances to the Efficient and Stable Expression of Transgenes in Plant Synthetic Biology Approaches

   • Ana Pérez-González, Elena Caro

   Pages 79-89

9. The New Massive Data: miRnomics and Its Application to Therapeutics

   • Mohammad Ahmed Khan, Maryam Mahfooz, Ghufrana Abdus Sami, Hashim AlSalmi, Abdullah E. A. Mathkoor, Ghazi A. Damanhauri et al.

   Pages 91-97

10. Microscopy-Based High-Throughput Analysis of Cells Interacting with Nanostructures

    • Raimo Hartmann, Wolfgang J. Parak

    Pages 99-115

11. Mathematical Chemodescriptors and Biodescriptors: Background and Their Applications in the Prediction of Bioactivity/Toxicity of Chemicals

    • Subhash C. Basak

    Pages 117-147

12. Epigenetics Moving Towards Systems Biology

    • Arif Malik, Misbah Sultana, Aamer Qazi, Mahmood Husain Qazi, Mohammad Sarwar Jamal, Mahmood Rasool

    Pages 149-160

This book introduces students to methods that will help them understand behaviour in terms of cellular components and their interactions in non-intuitive ways, which calls for an interdisciplinary approach combining mathematical, chemical, computational and biological strategies. Tibor Ganti was one of the early pioneers who proposed a theoretical framework to understand living principles in terms of chemical transformation cycles and their coupling. The twenty-first century then brought with it a novel ‘systems’ paradigm, which shone new light on all previous work and was accompanied by numerous implications for the way we conceive of chemical and biological complexity today. 

This book seeks to equip students to take advantage of any field that investigates living systems. Based on a conceptualisation of science-oriented branches, engineering-oriented branches and biology as astoundingly complex fields, those structures laden with biochemical detail encompass a deeper theory unifying our knowledge of designed systems. 

Readers will be pleasantly surprised at how lucidly the topics are presented. The book offers an indispensable resource for students and professionals working in systems and synthetic biology or any of the various related fields of research.

• Bioinformatics
• Gene Regulatory Networks
• Integrative Biology
• Synthetic Biology
• Systems Biology

• Computational and Systems Biology Lab, National Centre for Cell Science, Pune, India

  Shailza Singh

Shailza Singh is working as Scientist D at National Centre for Cell Science, Pune. She works in the field of Computational and Systems Biology wherein she is trying to integrate the action of regulatory circuits, cross-talk between pathways and the non-linear kinetics of biochemical processes through mathematical models. The current thrust in her laboratory is to explore the possibility of network-based drug design and how rationalized therapies may benefit from Systems Biology. She is the recipient of RGYI (DBT), DST-Young Scientist and INSA (Bilateral Exchange Programme). She is the reviewer of various international and national grants funded from government organizations.

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