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Regulation of the Contractile Cycle in Smooth Muscle

  • Conference proceedings
  • © 1995

Overview

Editors:
  1. Takeshi Nakano

    1. Mie University of School Medicine, Mie, Japan

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  2. David J. Hartshorne

    1. University of Arizona, Tucson, USA

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Table of contents (15 papers)

  1. Front Matter

    Pages II-VIII
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  2. Dynamics of Ion Channels Modified by Mobilized Calcium in Vascular Smooth Muscle Cells

    • Kenji Kitamura, Hirosi Kuriyama
    Pages 1-45

  3. Dual Regulation of Smooth Muscle Contraction

    • Hideaki Karaki
    Pages 47-59

  4. Cytosolic Calcium Concentration-Force Relation in Vascular Smooth Muscle

    • Hideo Kanaide
    Pages 61-72

  5. Cross-Bridge Cycle in Phasic and Tonic Smooth Muscle

    • A. V. Somlyo, E. Nishiye, A. Khromov, A. P. Somlyo
    Pages 73-84

  6. Role of Protein Kinase C in the G Protein-Mediated Increase in Myofilament Ca2+ Sensitivity in Skinned Arterial Smooth Muscle of the Rabbit

    • Takeo Itoh, Yoshimasa Watanabe, Makoto Yoshida, Akito Suzuki
    Pages 85-102

  7. Regulation of Ca2+-Dependent Phosphorylation of 20-kDa Myosin Light Chain by the Small Molecular Weight G Protein rho p21 in Vascular Smooth Muscle Cells

    • Yoh Takuwa, Masakuni Noda, Chikako Yasuda, Mamoru Kumada, Kiyoshi Kurokawa
    Pages 103-110

  8. Molecular Dissection of Regulatory Light Chain Function in Vertebrate Smooth Muscle Myosins

    • John Kendrick-Jones, Tony Rowe, Ana C. Rasera da Silva, Fernando C. Reinach
    Pages 111-130

  9. Autoinhibition of Myosin Light Chain Kinase

    • Satoshi Matsushima, Masaaki Ito, David J. Hartshorne, Vince Guerriero Jr.
    Pages 131-137

  10. Regulation of Myosin Light Chain Kinase Activity in Smooth Muscle

    • Kristine E. Kamm, Katherine Luby-Phelps, Malu G. Tansey, Patricia J. Gallagher, James T. Stull
    Pages 139-158

  11. Actin-Binding Property of Myosin Light Chain Kinase and Its Role in Regulating Actin-Myosin Interaction of Smooth Muscle

    • Li-Hong Ye, Kohichi Hayakawa, Tsuyoshi Okagaki, Kazuhiro Kohama
    Pages 159-173

  12. Pharmacomechanical Coupling Through Regulation of Myosin Light Chain Phosphatase

    • A. P. Somlyo, M. Gong, K. Iizuka, T. Haystead, A. V. Somlyo
    Pages 175-185

  13. Smooth Muscle Myosin Phosphatase

    • Masaaki Ito, Hiroyuki Shimizu, Masatoshi Miyahara, Jian-Hua Feng, Setsuya Okubo, Kazuhito Ichikawa et al.
    Pages 187-200

  14. Structure and Expression of Vascular Smooth Muscle Calponin

    • Katsuhito Takahashi, Hiroaki Masuda, Michiko Takagi, Yoshimi Eshita, Nobuhiko Shibata
    Pages 201-209

  15. Modulation of Vascular Smooth Muscle Contraction by Calponin Phosphorylation

    • Toshio Tanaka, Michiko Naka, Terumasa Mino, Uhito Yuasa, Fumiaki Nakamura, Junichi Yamamoto et al.
    Pages 211-221

  16. Smooth Muscle Cell Differentiation and Its Abnormality in Vascular Diseases

    • Ryozo Nagai, Masanori Aikawa, Makoto Kuro-o, Ichiro Manabe, Yasunari Sakomura, Masafumi Watanabe et al.
    Pages 223-232

  17. Back Matter

    Pages 233-239
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Keywords

About this book

At the Mie International Symposium held in Japan in April 1994, leading scientists reviewed recent advances in the understanding of the contractile mechanism in smooth muscle. The present volume collects the papers presented at the symposium, summarizing the latest advances in smooth muscle function and emphasizing important components of the contraction-relaxation cycle. Topics include a discussion of the smooth muscle cell membrane, with emphasis on its ion channels; the regulation of cytosolic Ca2+ levels and the relationship to force in smooth muscle; aspects of the two key regulatory enzymes involved with myosin phosphorylation-dephosphorylation; the molecular basis for pharmacomechanical coupling in smooth muscle; developments in the basic contractile mechanisms involving the crossbridge cycle of tonic and phasic muscle; the role of myosin light chains; and many others. The approach is broad and presents contemporary opinions in pharmacology, physiology, and biochemistry as they relate to smooth muscle function. The book will appeal not only to those working in these disciplines, but to vascular clinicians, obstetric-gynecological physicians, and gastroenterologists as well.

Editors and Affiliations

  • Mie University of School Medicine, Mie, Japan

    Takeshi Nakano

  • University of Arizona, Tucson, USA

    David J. Hartshorne

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