Artificial Oxygen Carrier

1. Front Matter

   Pages I-XV

   PDF

2. Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes

   • K. Kobayashi, H. Horinouchi, M. Watanabe, Y. Izumi, Y. Teramura, A. Nakagawa et al.

   Pages 1-21

3. Red Blood Cell Substitutes: Past, Present, and Future

   • Thomas Ming Swi Chang

   Pages 22-33

4. Inhaled Nitric Oxide: Update 2003

   • W.M. Zapol

   Pages 34-37

5. The Role of p50 in Tissue Oxygen Delivery by Cell-Free Oxygen Carriers

   • Robert M. Winslow

   Pages 38-52

6. Repetitive Administration of Hemoglobin Raffimer in Experimental Models and Clinical Applications

   • Hae Won Kim, George Biro, A. Gerson Greenburg

   Pages 53-61

7. Oxygen Gradients In Vivo Seen by a High Oxygen Affinity HB Polymer

   • Enrico Bucci, Raymond C. Koehler

   Pages 62-69

8. Oxygen Partition Between Microvessels and Tissue: Significance for the Design of Blood Substitutes

   • Amy G. Tsai, Barbara Friesenecker, Marcos Intaglietta

   Pages 70-74

9. Endothelial Cell Response to Hemoglobin Based Oxygen Carriers. Is the Attenuation of Pathological Reactions Possible?

   • Jan Simoni

   Pages 75-126

10. The Development of a Second-Generation, Designer, Recombinant Hemoglobin

    • Kenneth E. Burhop

    Pages 127-134

11. Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers

    • Hiromi Sakai, Keitaro Sou, Shinji Takeoka, Koichi Kobayashi, Eishun Tsuchida

    Pages 135-168

12. Successful Ex Vivo Normothermic Liver Perfusion with Purely Artificial Products Using Artificial Blood

    • Tadashi Katsuramaki, Akihiro Nui, Hitoshi Kikuchi, Kazuma Kukita, Minoru Nagayama, Makoto Meguro et al.

    Pages 169-175

13. Effect of Hemoglobin-Based Blood Substitutes on Nitric Oxide Transport: Mathematical Models

    • Aleksander S. Popel, Mahendra Kavdia, Nikolaos M. Tsoukias

    Pages 176-185

14. New Strategy for the Preparation of NO-Treated Red Blood Cells as a Blood Substitute

    • Antonio Tsuneshige, Takashi Yonetani

    Pages 186-192

15. Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme

    • Teruyuki Komatsu, Eishun Tsuchida

    Pages 193-204

16. Micromechanical Properties of Newly Developed Polyelectrolyte Microcapsules (PEMC)

    • Hans Bäumler, Christina Kelemen, Rita Mitlöhner, Radostina Georgieva, Astrid Krabi, Silke Schäling et al.

    Pages 205-216

17. Intravascular Microbubbles: An Ultra-Effective Means of Transporting Oxygen

    • Claes E.G. Lundgren, Guri W. Bergoe, Ingvald M. Tyssebotn

    Pages 217-220

18. Oxygen-Dependent and Oxygen-Independent Effects of Perftoran

    • Eugene Maevsky, Genrih Ivanitsky

    Pages 221-228

19. State of the Art and Challenges in Blood Substitutes Research: A Case Study on Perfluorocarbon-Based Oxygen Carriers

    • Juan Carlos Briceño

    Pages 229-236

20. Semifluorinated Alkanes as Stabilizing Agents of Fluorocarbon Emulsions

    • Sabina Marie Bertilla, Pascal Marie, Marie Pierre Krafft

    Pages 237-251

This volume of the Keio University International Symposia for Life Sciences and Medicine contains the proceedings of the 13th symposium held under the sponsorship of the Keio University Medical Science Fund. The fund was est- lished by the generous donation of the late Dr. Mitsunada Sakaguchi. The Keio University International Symposia for Life Sciences and Medicine constitute one of the core activities sponsored by the fund,of which the objective is to contribute to the international community by developing human resources, promoting scienti?c knowledge, and encouraging mutual exchange. Each year, the Committee of the International Symposia for Life Sciences and Medicine selects the most signi?cant symposium topics from applications received from the Keio medical community. The publication of the proce- ings is intended to publicize and distribute the information arising from the lively discussions of the most exciting and current issues presented during the symposium. On behalf of the Committee, I am most grateful to the late Dr. Sakaguchi, who made the series of symposia possible. We are also grateful to the prominent speakers for their contribution to this volume. In addition, we would like to acknowledge the ef?cient organizational work performed by the members of the program committee and the staff of the fund. Naoki Aikawa, M. D. , D. M. Sc. , F. A. C. S.

• blood
• infectious disease
• plasma
• research

• Division of General Thoracic Surgery, Department of Surgery School of Medicine, Keio University, Tokyo, Japan

  Koichi Kobayashi, Hirohisa Horinouchi

• Department of Polymer Chemistry, Waseda University, Tokyo, Japan

  Eishun Tsuchida

Policies and ethics