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  • © 2014

The Intervertebral Disc

Molecular and Structural Studies of the Disc in Health and Disease

  • Comprehensive approach to recent research results on disc de- and regeneration

  • Numerous 4c illustrations

  • Contributions of international authors

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-x
  2. Biomechanical and Molecular Studies of the Intervertebral Disc

    1. Front Matter

      Pages 1-1
    2. The Intervertebral Disc: Overview of Disc Mechanics

      • Daniel H. Cortes, Dawn M. Elliott
      Pages 17-31
    3. Development of the Intervertebral Disc

      • Megan K. Cox, Rosa Serra
      Pages 33-51
    4. Proteoglycans of the Intervertebral Disc

      • James Melrose, Peter Roughley
      Pages 53-77
    5. The Role of the ADAMTS Proteins in the Intervertebral Disc

      • Jason C. Ho, James Wylie, Suneel S. Apte
      Pages 125-135
  3. Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities

    1. Front Matter

      Pages 137-137
    2. Epidemiology of Lumbar Disc Degeneration

      • Yue Wang, Michele C. Battié
      Pages 139-156
    3. Genetic Basis of Intervertebral Disc Degeneration

      • Anita Yee, Danny Chan
      Pages 157-176
    4. Pathogenesis of Intervertebral Disc Degeneration

      • Stephen M. Richardson, Anthony J. Freemont, Judith A. Hoyland
      Pages 177-200
    5. Imaging Modalities for Studying Disc Pathology

      • Ari Borthakur, Ravinder Reddy
      Pages 201-212
    6. Surgical Indications for Lumbar Degenerative Disease

      • Ravi R. Patel, Jeffrey A. Rihn, Ravi K. Ponnoppan, Todd J. Albert
      Pages 213-224
    7. Spinal Motion Restoration Devices for the Degenerative Disc

      • Daniel G. Kang, Melvin D. Helgeson, Alexander R. Vaccaro
      Pages 225-246
    8. The Nonsurgical Treatment of Back Pain

      • Isaac L. Moss, Howard S. An, Francis H. Shen, Zemin Li, Gunnar B. J. Andersson, Yejia Zhang
      Pages 247-259
    9. Clinical Features and Pathobiology of Chordoma

      • John A. Abraham, Brian Neuman, Francis J. Hornicek
      Pages 277-288

About this book

The intervertebral disc is a complex structure that separates opposing vertebrae, permits a wide range of motion, and accommodates high biomechanical forces. Disc degeneration leads to a loss of function and is often associated with excruciating pain.

Written by leading scientists and clinicians,  the first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies to mitigate the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is devoted to approaches to model normal development and elucidate the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques. 

The book bridges the gap between the basic and clinical sciences; the target audience includes basic scientists, orthopaedists and neurologists, while at the same time appealing to the needs of  graduate students, medical students, interns and fellows.

Editors and Affiliations

  • Jefferson Medical College Div Ortho Rsch/Dept Othro Surgery, Thomas Jefferson University, Philadelphia, USA

    Irving M. Shapiro

  • Jefferson Medical College Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, USA

    Makarand V. Risbud

About the editors

Irving M. Shapiro BDS, PhD

Makarand Risbud, Ph.D.

Division of Orthopaedic Research, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA

Bibliographic Information

  • Book Title: The Intervertebral Disc

  • Book Subtitle: Molecular and Structural Studies of the Disc in Health and Disease

  • Editors: Irving M. Shapiro, Makarand V. Risbud

  • DOI: https://doi.org/10.1007/978-3-7091-1535-0

  • Publisher: Springer Vienna

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Wien 2014

  • Hardcover ISBN: 978-3-7091-1534-3Published: 13 September 2013

  • Softcover ISBN: 978-3-7091-1943-3Published: 23 August 2016

  • eBook ISBN: 978-3-7091-1535-0Published: 02 September 2013

  • Edition Number: 1

  • Number of Pages: X, 446

  • Number of Illustrations: 88 b/w illustrations, 42 illustrations in colour

  • Topics: Surgical Orthopedics, Neurosurgery, Orthopedics

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access