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Leucocyte Trafficking

The Role of Fucosyltransferases and Selectins

  • Conference proceedings
  • © 2004

Overview

Editors:
  1. Alf Hamann

    1. Experimental Rheumatology, Medical Clinic, University Hospital Charité, Berlin, Germany

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  2. Khusru Asadullah

    1. Corporate Research Business, Area Dermatology, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Arndt Schottelius

    1. Corporate Research Business, Area Dermatology, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 44)

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Table of contents (11 papers)

  1. Front Matter

    Pages I-XIV
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  2. Selectin Ligands on T Cells

    • A. Hamann, U. Syrbe, U. Kretschmer, S. Jennrich, J. Hühn
    Pages 1-14

  3. Skin Homing T Cells

    • M. Akdis, S. Klunker, K. Blaser, C. A. Akdis
    Pages 15-26

  4. Cutaneous Lymphocyte Localization in the Pathogenesis of Psoriasis

    • M. P. Schön
    Pages 27-51

  5. The Role of Fucosylation in Leukocyte Adhesion Deficiency II

    • D. Vestweber, K. Lühn, T. Marquardt, M. Wild
    Pages 53-74

  6. Substrate Specificity and Synthetic Use of Glycosyltransferases

    • J. Thiem
    Pages 75-94

  7. Control of FucT-VII Expression in CD4+ T Cells

    • G. S. Kansas
    Pages 95-107

  8. Selectin Avidity Modulation by Chemokines at Subsecond Endothelial Contacts: A Novel Regulatory Level of Leukocyte Trafficking

    • O. Dwir, V. Grabovsky, R. Alon
    Pages 109-135

  9. Interactions of Selectins with PSGL-1 and Other Ligands

    • R. P. McEver
    Pages 137-147

  10. Saturation Transfer Difference NMR Spectroscopy for Identifying Ligand Epitopes and Binding Specificities

    • B. Meyer, J. Klein, M. Mayer, R. Meinecke, H. Möller, A. Neffe et al.
    Pages 149-167

  11. Chemokine Receptor Antagonists from Discovery to the Clinic

    • R. Horuk
    Pages 169-190

  12. The Role of Chemokines in Inflammatory Skin Diseases

    • G. Girolomoni, S. Pastore, A. Cavani, C. Albanesi
    Pages 191-225

  13. Back Matter

    Pages 227-238
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Keywords

About this book

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

Editors and Affiliations

  • Experimental Rheumatology, Medical Clinic, University Hospital Charité, Berlin, Germany

    Alf Hamann

  • Corporate Research Business, Area Dermatology, Schering AG, Berlin, Germany

    Khusru Asadullah, Arndt Schottelius

Bibliographic Information

  • Book Title: Leucocyte Trafficking

  • Book Subtitle: The Role of Fucosyltransferases and Selectins

  • Editors: Alf Hamann, Khusru Asadullah, Arndt Schottelius

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-05397-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2004

  • Hardcover ISBN: 978-3-540-40112-4Published: 07 October 2003

  • Softcover ISBN: 978-3-662-05399-7Published: 03 October 2013

  • eBook ISBN: 978-3-662-05397-3Published: 29 June 2013

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XIV, 242

  • Topics: Human Physiology, Immunology, Molecular Medicine, Dermatology

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