Molecular Aspects of Myeloid Stem Cell Development

1. Front Matter

   Pages I-XIV

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2. Regulation of Myeloid Differentiation, Growth Arrest and Apoptosis

   1. Front Matter

      Pages 1-1

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   2. Molecular Control of Development in Normal and Leukemic Myeloid Cells by Cytokines, Tumor Suppressor and Oncogenes

      • L. Sachs

      Pages 3-5

   3. Retinoic Acid Receptors in Hematopoiesis

      • Steven J. Collins, Schickwann Tsai, Irwin Bernstein

      Pages 7-15

   4. Role of c-myc in Myeloid Differentiation, Growth Arrest and Apoptosis

      • B. Hoffman, D. A. Liebermann, M. Selvakumaran, H. Q. Nguyen

      Pages 17-27

   5. Self Renewal and Differentiation in Primary Avian Hematopoietic Cells: An Alternative to Mammalian in Vitro Models?

      • H. Beug, T. Metz, E. W. Müllner, M. J. Hayman

      Pages 29-39

3. Receptors and Signal Transduction

   1. Front Matter

      Pages 41-41

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   2. The Effect of C-raf Antisense Oligonucleotides on Growth Factor-Induced Proliferation of Hematopoietic Cells

      • J. R. Keller, F. W. Ruscetti, G. Heidecker, D. M. Linnekin, U. Rapp, J. Troppmair et al.

      Pages 43-53

   3. Protein Kinase C-δ, an Important Signaling Molecule in the Platelet-Derived Growth Factor β Receptor Pathway

      • W. Li, J. H. Pierce

      Pages 55-65

   4. Novel Adapter Proteins that Link the Human GM-CSF Receptor to the Phosphatidylino-sitol 3-Kinase and Shc/Grb2/ras Signaling Pathways

      • M. Jücker, R. A. Feldman

      Pages 67-75

4. Myb: Proliferation and Maintenance of Stage Specific Genes

   1. Front Matter

      Pages 77-77

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   2. Functional Analysis of the c-myb Proto-Oncogene

      • H. H. Lin, D. C. Sternfeld, S. G. Shinpock, R. A. Popp, M. L. Mucenski

      Pages 79-87

   3. Structure and Function of the Proteins Encoded by the myb Gene Family

      • C. Kanei-Ishii, T. Nomura, K. Ogata, A. Sarai, T. Yasukawa, S. Tashiro et al.

      Pages 89-98

   4. The c-Myb Negative Regulatory Domain

      • T. J. Gonda, D. Favier, P. Ferrao, E. M. Macmillan, R. Simpson, F. Tavner

      Pages 99-109

5. Myeloid-Specific Transcription

   1. Front Matter

      Pages 111-111

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   2. Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1

      • M. C. Simon, M. Olson, E. Scott, A. Hack, G. Su, H. Singh

      Pages 113-119

   3. A Role for STAT Family Transcription Factors in Myeloid Differentiation

      • F. Barahmand-pour, A. Meinke, Matthias Kieslinger, A. Eilers, T. Decker

      Pages 121-128

   4. Regulation of C/EBPβ/NF-M Activity by Kinase Oncogenes

      • G. Twamley-Stein, E. Kowenz-Leutz, S. Ansieau, A. Leutz

      Pages 129-136

   5. Function of PU.1 (Spi-1), C/EBP, and AML1 in Early Myelopoiesis: Regulation of Multiple Myeloid CSF Receptor Promoters

      • D.-E. Zhang, S. Hohaus, M. T. Voso, H.-M. Chen, L. T. Smith, C. J. Hetherington et al.

      Pages 137-147

   6. Regulation of Immature Myeloid Cell Differentiation by PEBP2/CBF, MYB, C/EBP and ETS Family Members

      • A. D. Friedman

      Pages 149-157

A workshop on "MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT" was held at the Historic Inns in Annapolis, MD during April 30-May 3, with approximately 70 persons attend­ ing. The enormous success of this meeting was attributable to the recent outburst of information generated from two areas of study: transcriptional regulation of developmentally important myeloid genes and molecular dissection of chromosomal abnormalities in human myeloid leukemias. It was reassuring that studies of normal myelopoiesis and abnormal myelopoiesis, as observed in dys­ plasias and neoplasia, are revealing several interrelated mechan­ isms of gene regulation. However, great challenges await us as we try to determine how these and other mechanisms in this intricate system orchestrate the ultimate fate of cells e. g. proliferation, differentiation or apoptosis. This volume of Current Topics in Micro­ biology encapsulates many of the key aspects of the workshop summarizing research over the past few years on the ontogeny and pathology of myeloid cells. Investigations into the complex process of normal myeloid cell . maturation were first made possible through development of in vitro clonigenic assays. These established the relationships of colony stimulating factors, interleukins and their combinations to the specific fates of myeloid progenitors derived from the bone , marrow and spleen. Molecular studies became feasible, however, through the later establishment of several cell culture systems in­ volving immortalized cells which, under the proper induction, could fairly accurately recapitulate the myelopoietic process.

• Knochenmark
• apoptosis
• cell
• chromosome
• cytokine
• growth
• growth factor
• hematopoiesis
• leukemia
• macrophages
• protein
• proteins
• regulation
• transcription
• virus

• Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA

  Linda Wolff

• Department of Pathology, Yale University School of Medicine, New Haven, USA

  Archibald S. Perkins

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