Minimal Neoplasia

1. Front Matter

   Pages n1-IX

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2. General Aspects

   1. Minimal Neoplasia as a Challenge for Early Cancer Detection

      • L. G. Koss

      Pages 1-8

   2. Morphology of Minimal Invasion

      • P. Sträuli

      Pages 9-13

   3. Molecular Biology of Minimal Invasion

      • M. Mareel, F. van Roy, E. Bruyneel, J. Bolscher, D. Schallier, M. de Mets

      Pages 14-20

   4. Minimal Neoplasias in Experimental Liver Carcinogenesis

      • H. M. Rabes

      Pages 21-27

3. Pathology and Therapy

   1. Minimal Endometrial Carcinoma

      • L. D. Stoddard

      Pages 28-38

   2. Therapeutic Procedure for Minimal Endometrial Cancer

      • J. Baltzer

      Pages 39-46

   3. Minimal Cervical Cancer: Definition and Histology

      • Y. S. Fu, J. S. Berek

      Pages 47-56

   4. Therapy of Minimal Cervical Cancer

      • H. G. Bender, H.-G. Schnürch, K. W. Degen

      Pages 57-64

   5. Anatomic Markers of Human Mammary Premalignancy and Incipient Breast Cancer

      • D. L. Page

      Pages 65-72

   6. Treatment Aspects of Minimal Breast Cancer

      • F. K. Beller, C. D. Nitsch, H. Nienhaus

      Pages 73-84

   7. Incipient Prostate Cancer: Definition, Histology, and Clinical Consequences

      • G. Dhom

      Pages 85-93

   8. Incipient Cancer of the Colon: Definition and Histology

      • B. Wiebecke

      Pages 94-103

   9. Immunological Approaches for Early Cancer Detection

      • D. M. Goldenberg

      Pages 104-113

   10. Therapeutic Consequences of Minimal Neoplasia of the Colon

       • J. W. Cole

       Pages 114-118

   11. Early Cancer of the Lung

       • K.-M. Müller

       Pages 119-130

   12. Minimal Thyroid Neoplasia

       • W. Böcker, S. Schröder, H. Dralle

       Pages 131-138

   13. Minimal Thyroid Cancer: Clinical Consequences

       • I. G. Böttger

       Pages 139-145

   14. Cryptic Gliomas

       • F. Gullotta

       Pages 146-151

   15. Cytogenetics of Preleukemic Stages in Experimental and Human Leukemogenesis

       • H. J. Seidel, F. Carbonell, H. Hameister, J. Eul

       Pages 152-158

Minimal neoplasia may be defined as a small cancer that has progressed beyond its site of primary origin into the surrounding tissue, but that has not yet reached the stage of deeper invasion or metastasization. The basic principles of this minimal cancer are presented in chapters on molecular, biological and experimental aspects, and, in particular, on the clinical manifestations in various organs: preleukemia, incipient lymphoma, and minimal carcinomas of the uterine cervix, breast, thyroid, larynx, lung, prostate, stomach and colon. A separate chapter is devoted to cryptic gliomas. The latest morphological methods including cytology, early clinical diagnostics and, in particular, radiodiagnostics, are considered. The reader can expect up-to-date information about prompt diagnosis of the very early manifestations of cancer, together with inferences on therapy, which, especially in tumors of the uterine cervix, breast and thyroid, differs considerably from the treatment of advanced neoplasia.

• breast cancer
• cancer
• carcinogenesis
• carcinoma
• cytogenetics
• diagnostics
• genetics
• histology
• histopathology
• leukemia
• liver
• lymphoma
• molecular biology
• pathology
• prostate cancer

• Gerhard-Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität Münster, Münster, Germany

  Ekkehard Grundmann

• Frauenklinik, Medizinische Einrichtungen, Universität Düsseldorf, Düsseldorf, Germany

  Lutwin Beck

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