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Toxicology of Metals

Biochemical Aspects

  • Book
  • © 1995

Overview

Editors:
  1. Robert A. Goyer

    1. Department of Pathology, University of Western Ontario, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. M. George Cherian

    1. Department of Pathology, University of Western Ontario, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 115)

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Table of contents (19 chapters)

  1. Front Matter

    Pages I-XXII
    Download chapter PDF

  2. Transplacental Transfer of Lead and Cadmium

    • R. A. Goyer
    Pages 1-17

  3. Porphyrin Metabolism as Indicator of Metal Exposure and Toxicity

    • J. S. Woods
    Pages 19-52

  4. Membrane Transporters as Sites of Action and Routes of Entry for Toxic Metals

    • D. C. Dawson, N. Ballatori
    Pages 53-76

  5. Immunotoxicology of Metals

    • L. Pelletier, P. Druet
    Pages 77-92

  6. Effects of Metals on Gene Expression

    • J. Koropatnick, M. E. I. Leibbrandt
    Pages 93-120

  7. Metallothionein and Its Interaction with Metals

    • M. G. Cherian
    Pages 121-137

  8. Biochemical Mechanisms of Aluminum Toxicity

    • E. H. Jeffery
    Pages 139-161

  9. Mercury Toxicity

    • K. Miura, A. Naganuma, S. Himeno, N. Imura
    Pages 163-187

  10. Toxicology of Cadmium

    • P. L. Goering, M. P. Waalkes, C. D. Klaassen
    Pages 189-214

  11. Chromium Toxicokinetics

    • E. J. O’Flaherty
    Pages 215-228

  12. Metals and Stress Proteins

    • P. L. Goering, B. R. Fisher
    Pages 229-266

  13. Metals and Anticancer Drug Resistance

    • J. S. Lazo
    Pages 267-278

  14. Chemistry of Chelation: Chelating Agent Antagonists for Toxic Metals

    • M. M. Jones
    Pages 279-304

  15. Therapeutic Use of Chelating Agents in Iron Overload

    • D. M. Templeton
    Pages 305-331

  16. Zinc Fingers and Metallothionein in Gene Expression

    • J. Zeng, J. H. R. Kägi
    Pages 333-347

  17. Role of Active Oxygen Species in Metal-Induced DNA Damage

    • S. Kawanishi
    Pages 349-371

  18. Metal Mutagenesis

    • T. G. Rossman
    Pages 373-405

  19. Biological Mechanisms and Toxicological Consequences of the Methylation of Arsenic

    • M. Styblo, M. Delnomdedieu, D. J. Thomas
    Pages 407-433

  20. Bacterial Plasmid-Mediated Resistances to Mercury, Cadmium, and Copper

    • S. Silver, M. Walderhaug
    Pages 435-458
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Keywords

About this book

The toxicology of metals has been concerned in the past with effects that produced clinical signs and symptoms. However, this view of metal toxicology has expanded in recent years due principally to two advances. There has been a considerable increase in our knowledge of the biochemical effects of metals. In addition, biomarkers of toxicity can now be recognized that identify toxicity at levels of exposure that do not produce overt clinical effects. Thus, the toxicology of metals is now focused on nonclinical events that reflect adverse health effects. This new awareness has produced the challenge of determining the lowest adverse level of exposure. With increasing analytical sensitivity and methodologies to detect small changes at the molecular level, the lowest level of exposure of some toxic metals, like lead, is very small. Indeed, for metals in which there is no biologic requirement, it may be questioned whether there is a level of exposure that does not produce some degree of toxicity. For essential metals, the question is being asked as to the levels at which exposure exceeds biologic require­ ments and excess exposure becomes toxic. The appropriateness of health decisions and the formation of public policy are dependent on the availability of current scientific information that addresses these questions. The information in this volume is intended to be a resource for this purpose as well as a reference for students of toxicology and other health professionals.

Editors and Affiliations

  • Department of Pathology, University of Western Ontario, Canada

    Robert A. Goyer, M. George Cherian

Bibliographic Information

  • Book Title: Toxicology of Metals

  • Book Subtitle: Biochemical Aspects

  • Editors: Robert A. Goyer, M. George Cherian

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-79162-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-642-79164-2Published: 22 November 2011

  • eBook ISBN: 978-3-642-79162-8Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXII, 467

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Internal Medicine

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