Skip to main content
SpringerLink
Log in

Transmissible Spongiform Encephalopathies:

Scrapie, BSE and Related Human Disorders

  • Book
  • © 1991

Overview

Editors:
  1. Bruce W. Chesebro

    1. Laboratory of Persistent Viral Diseases Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 172)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. The Human Spongiform Encephalopathies: Kuru, Creutzfeldt-Jakob Disease, and the Gerstmann-Sträussler-Scheinker Syndrome

    • P. Brown, D. C. Gajdusek
    Pages 1-20

  3. Bovine Spongiform Encephalopathy

    • J. W. Wilesmith, G. A. H. Wells
    Pages 21-38

  4. Purification of Scrapie Agents: How Far Have We Come?

    • D. C. Bolton, P. E. Bendheim
    Pages 39-55

  5. The Scrapie Fibril Protein and Its Cellular Isoform

    • J. Hope, J. Manson
    Pages 57-74

  6. Ultrastructural Studies of Prions

    • M. P. McKinley, S. B. Prusiner
    Pages 75-91

  7. In Vitro Expression and Biosynthesis of Prion Protein

    • B. Caughey
    Pages 93-107

  8. Prion Protein Genes: Evolutionary and Functional Aspects

    • B. Oesch, D. Westaway, S. B. Prusiner
    Pages 109-124

  9. Scrapie Strain Variation and Its Implications

    • M. E. Bruce, H. Fraser
    Pages 125-138

  10. Evidence for Biological and Structural Diversity Among Scrapie Strains

    • R. J. Kascsak, R. Rubenstein, R. I. Carp
    Pages 139-152

  11. Genetics of Prion Diversity and Host Susceptibility

    • G. A. Carlson
    Pages 153-164

  12. Natural Transmission and Genetic Control of Susceptibility of Sheep to Scrapie

    • N. Hunter
    Pages 165-180

  13. The Scrapie Agent In Vitro

    • R. Race
    Pages 181-193

  14. The Scrapie Agent: “A Virus by Any Other Name”

    • R. G. Rohwer
    Pages 195-232

  15. Novel Properties and Biology of Scrapie Prions

    • S. B. Prusiner
    Pages 233-257

  16. Identifying and Mapping Changes in Gene Expression Involved in the Neuropathology of Scrapie and Alzheimer’s Disease

    • J. Diedrich, S. Wietgrefe, A. Haase, J. Duguid, R. I. Carp
    Pages 259-274

  17. Search for a Transmissible Agent in Alzheimer’s Disease: Studies of Human Buffy Coat

    • E. E. Manuelidis, L. Manuelidis
    Pages 275-280

  18. Back Matter

    Pages 281-290
    Download chapter PDF
Back to top

Keywords

About this book

In spite of a long history of intense investigation the transmissible spongiform encephalopathies remain a poorly understood family of neurodegenerative diseases. This group of diseases has been described in a wide variety of animal species and includes kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler syndrome in humans, and scrapie, bovine spongiform encephalopathy, and related syndromes in ruminants and rodents. In all cases spongiform degeneration and astrocytosis are seen in specimens of brain and a filterable transmissible agent is present in the brain and some other tissues of affected individuals. However, the precise nature of this agent remains unknown. Agent infectivity, which can so far only be assayed by serial transmission to new individuals, be remarkably resistant to inactivation has been shown to by heat, chemicals, and irradiation. These properties create significant biohazard possibilities during exposure to infected tissues. Transmission between humans was originally reco­ gnized in the unique epidemiology of kuru in New Guinea tribesmen, and concern about transmission from animals to humans has re-emerged as a result of the current epidemic of bovine spongiform encephalopathy in dairy cattle in Great Britain. Although interspecies transmission has often been achieved experimentally, its efficiency is highly variable. There­ fore, the possibility of spread of bovine spongiform encephalopathy from cattle to humans or various animal populations cannot be accurately predicted at this time. This volume presents a comprehensive update of know­ ledge concerning the transmissible spongiform encephalo­ pathies.

Editors and Affiliations

  • Laboratory of Persistent Viral Diseases Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, USA

    Bruce W. Chesebro

Bibliographic Information

  • Book Title: Transmissible Spongiform Encephalopathies:

  • Book Subtitle: Scrapie, BSE and Related Human Disorders

  • Editors: Bruce W. Chesebro

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-76540-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1991

  • Softcover ISBN: 978-3-642-76542-1Published: 16 December 2011

  • eBook ISBN: 978-3-642-76540-7Published: 11 November 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 288

  • Topics: Virology, Neurosciences, Medical Microbiology, Internal Medicine, Cell Biology

Publish with us

Policies and ethics

Back to top

Search

Navigation