Surgical Research: Recent Concepts and Results

1. Front Matter

   Pages I-XVII

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2. Surgical Pathophysiology: Ischemia and Reperfusion, Microcirculation, Tissue Damage and Repair

   1. Front Matter

      Pages 1-1

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   2. New Aspects in the Formation of Vasogenic Brain Edema

      • A. Unterberg, A. Baethmann, M. Wahl, L. Schürer, A. Marmarou

      Pages 3-8

   3. Neurosurgical Research In Vitro: Contradiction or Promise?

      • O. Kempski, F. Staub, M. Zimmer, G. H. Schneider, A. Baethmann

      Pages 9-17

   4. Influence of the Inhalation Anesthetics Isoflurane and Enflurane on the Normal and Ischemic Myocardium

      • J. Hobbhahn, K. Peter, A. E. Goetz, P. Conzen

      Pages 18-30

   5. Prostaglandin, and Thromboxane Release in Critical States

      • W. Oettinger, H. G. Beger

      Pages 31-38

   6. New Perspectives in Resuscitation and Prevention of Multiple Organ System Failure

      • U. Kreimeier, K. Messmer

      Pages 39-50

   7. Histological, and Hemodynamic Alterations Produced by Progressive Ligation of the Pulmonary Artery Branches

      • F. A. Sanguinetti, N. Silva

      Pages 51-58

   8. A Model of Experimental Silicosis in a Compressed Air Environment

      • F. Krombach, R. Ronge, S. Hildemann, E. Fiehl, A. Wanders, D. Burkhardt et al.

      Pages 59-68

   9. The Role of Surgery in Cancer Metastasis of the Lung: Results and Trends

      • L. Sunder-Plassmann, H. Dienemann, G. Heberer

      Pages 69-74

3. Novel Technologies in Surgery and Medicine

   1. Front Matter

      Pages 75-75

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   2. Extracorporeal Shock-Wave Lithotripsy of Gallstones

      • M. Delius

      Pages 77-81

   3. Breakdown of Tumor Microcirculation Induced by Shock-Waves or Photodynamic Therapy

      • A. E. Goetz, R. Königsberger, J. Feyh, P. F. Conzen, W. Lumper

      Pages 82-93

   4. New Treatment Concepts for Insulin-Dependent Diabetes Mellitus

      • B. U. von Specht, A. Dibelius, H. Königsberger

      Pages 94-100

   5. Computer Applications in Surgical Research

      • R. Schosser, H. Forst, W. Gross, C. Weiss, H. Zeintl, K. Messmer

      Pages 101-116

4. Intestinal Immunology

   1. Front Matter

      Pages 117-117

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   2. Immune System of the Gut

      • G. Enders

      Pages 119-124

   3. Absorption of Macromolecules and Particles from the Gut

      • J. Seifert, W. Sass

      Pages 125-137

   4. Role of Immunology in Gastric Cytoprotection

      • R. K. Teichmann, E. Pratschke, H. H. Kraemling, H.-G. Liebich

      Pages 138-144

5. Transplantation Immunology

   1. Front Matter

      Pages 145-145

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Since surgery became a method of treating patients, progress in the field has been intimately associated with experimentation and serendipitous research. As in other clinical specialties advances in surgery can be considered to result from experimental attempts to increase basic knowledge and to improve technical skills. However, virtually in no other area do concepts and approaches of experimental research enter clinical routine as fast as in surgery. There are numerous examples of this. Thus, allocation of manpower and resources for surgical research can be considered particu- 1arly profitable as convincingly shown, for instance, in renal transplantation by comparison of the long-term burden of hemodialysis vs. kidney grafting, apart from the relief of suffering and misery. Surgery is a continuously spreading field, and so is surgical research. This volume is a case in point. Its spectrum reaches from basic molecular biological aspects of immune mechanisms to the current state of the art of pulmonary surgery of cancer metastases, and from the molecular processes of cell swelling in ischemic brain edema and blood-brain barrier damage to novel forms of resuscitation or of treatment of insulin-dependent diabetes mellitus. Surgical research faithfully reflects a constant reorientation of medical disciplines. Treatment of renal or gallbladder concrements was a major domain of surgery, where the introduction of extracorporeal shock wave treatment now supplies noninvasive, virtually conservative alternatives.

• brain
• cancer
• cell
• diabetes mellitus
• insulin
• kidney
• medicine
• pathophysiology
• patients
• resuscitation
• shock
• surgery
• tissue
• transplantation
• tumor

• Institute for Surgical Research, Klinikum Großhadern, Ludwig-Maximilians-University, Munich, Germany

  Alexander Baethmann

• Department of Experimental Surgery, Surgical University Clinic, Ruprecht-Karls-University, Heidelberg, Germany

  Konrad Messmer

Policies and ethics