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Organic Nitrates

  • Book
  • © 1975

Overview

Editors:
  1. Philip Needleman

    1. Pharmacology Department, Washington University, St. Louis, USA

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 40)

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Historical Background

    • John C. Krantz
    Pages 1-13

  3. Chemistry of Organic Nitrates

    • Eugene M. Johnson Jr.
    Pages 15-23

  4. Organic Nitrates: Analytical Techniques

    • Marc G. Bogaert
    Pages 25-37

  5. Pharmacological Properties

    • C. Jelleff Carr
    Pages 39-56

  6. Biotransformation of Organic Nitrates

    • Philip Needleman
    Pages 57-95

  7. The Pharmacological and Biochemical Interaction of Organic Nitrates with Sulfhydryls: Possible Correlations with the Mechanism for Tolerance Development, Vasodilation, and Mitochondrial and Enzyme Reactions

    • Philip Needleman, Eugene M. Johnson Jr.
    Pages 97-114

  8. Physiology and Pathophysiology of the Coronary Circulation and the Role of Nitroglycerin

    • Bertram Pitt
    Pages 115-130

  9. Mechanism of Action of Nitroglycerin: Coronary, Cardiac, and Systemic Effects

    • Stephen F. Vatner, Guy R. Heyndrickx
    Pages 131-161

  10. Use of Nitrates as Antianginal Agents

    • Wilbert S. Aronow
    Pages 163-174

  11. Back Matter

    Pages 175-198
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Keywords

About this book

Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although subยญ lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.

Editors and Affiliations

  • Pharmacology Department, Washington University, St. Louis, USA

    Philip Needleman

Bibliographic Information

  • Book Title: Organic Nitrates

  • Editors: Philip Needleman

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-66024-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin ยท Heidelberg 1975

  • Softcover ISBN: 978-3-642-66026-9Published: 15 November 2011

  • eBook ISBN: 978-3-642-66024-5Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XIV, 198

  • Topics: Medicine/Public Health, general, Pharmacy

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