Jaagsiekte Sheep Retrovirus and Lung Cancer

1. Front Matter

   Pages I-XI

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2. A History of Ovine Pulmonary Adenocarcinoma (Jaagsiekte) and Experiments Leading to the Deduction of the JSRV Nucleotide Sequence

   • D. F. York, G. Querat

   Pages 1-23

3. Pathology of Ovine Pulmonary Adenocarcinoma

   • M. De Las Heras, L. González, J. M. Sharp

   Pages 25-54

4. Natural History of JSRV in Sheep

   • J. M. Sharp, J. C. DeMartini

   Pages 55-79

5. Molecular Biology of Jaagsiekte Sheep Retrovirus

   • M. Palmarini, H. Fan

   Pages 81-115

6. Endogenous Retroviruses Related to Jaagsiekte Sheep Retrovirus

   • J. C. DeMartini, J. O. Carlson, C. Leroux, T. Spencer, M. Palmarini

   Pages 117-137

7. Transformation and Oncogenesis by Jaagsiekte Sheep Retrovirus

   • H. Fan, M. Palmarini, J. C. DeMartini

   Pages 139-177

8. Identification of Hyal2 as the Cell-Surface Receptor for Jaagsiekte Sheep Retrovirus and Ovine Nasal Adenocarcinoma Virus

   • A. D. Miller

   Pages 179-199

9. Enzootic Nasal Adenocarcinoma of Sheep and Goats

   • M. De las Heras, A. Ortín, C. Cousens, E. Minguijón, J. M. Sharp

   Pages 201-223

10. Pathology of Human Bronchioloalveolar Carcinoma and Its Relationship to the Ovine Disease

    • J.-F. Mornex, F. Thivolet, M. De Las Heras, C. Leroux

    Pages 225-248

11. Back Matter

    Pages 249-252

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Retroviruses have been of great importance to biomedical science for the past half century. Initially, studies on oncogenic animal retroviruses provided important insights into molecular processes in carcinogenesis – most notably the existence and mechanisms of action of oncogenes and proto-oncogenes. Moreover, several human diseases are caused by retroviruses, including AIDS, adult T-cell leukemia and the neurological disease HAM/TSP. The topic of this volume is a relatively unknown animal retrovirus, jaagsiekte sheep retrovirus, the causative agent of transmissible lung cancer in sheep –ovine pulmonary adenocarcinoma. The disease was first documented in South Africa in the 1800s, it has a wide geographical distribution, and it is of economic importance in high endemic regions. However, until very recently the nature of the etiologic agent was unclear, and relatively few laboratories actively studied the disease.

• AIDS
• diseases
• gene
• gene therapy
• leukemia
• maedi virus
• molecular biology
• oncogenesis
• ovine pulmonary adenocarcinoma
• pathology
• retroviruses
• reverse transcriptase
• virus
• visna virus

• Cancer Research Institute, University of California, Irvine, Irvine, USA

  Hung Fan

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