Developmental Biology of Peripheral Lymphoid Organs

1. Front Matter

   Pages i-x

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2. Introduction: Evolution of Peripheral Lymphoid Organs

   • Péter Balogh

   Pages 1-3

3. Common Themes in Lymphoid Organ Development

   1. Front Matter

      Pages 5-5

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4. Common themes in lymphoid organ development

   1. Cellular Partners in the Embryonic Induction of Lymphoid Territories: Origins and Transcriptional Regulation

      • Péter Balogh

      Pages 7-13

   2. Lymphotoxin/Tumour Necrosis Factor Family Members as Morphogenic Factors

      • Péter Balogh

      Pages 15-24

   3. NF-κB Signalling and Lymphoid Tissue Organogenesis

      • Cecile Benezech, Emma Mader, Falk Weih, Jorge Caamaño

      Pages 25-38

   4. Homeostatic Chemokines, Cytokines and Their Receptors in Peripheral Lymphoid Organ Development

      • Péter Balogh

      Pages 39-45

5. Development of Lymph Nodes in Humans and Rodents

   1. Front Matter

      Pages 47-47

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6. Development of lymph nodes in humans and rodents

   1. Developmental Relationship and Convergence Between the Formation of Lymphoid Organs and Lymphatic Vasculature

      • Péter Balogh

      Pages 49-58

   2. Development and Structure of Lymph Nodes in Humans and Mice

      • Tom Cupedo, Mark C. Coles, Henrique Veiga-Fernandes

      Pages 59-74

   3. Development of Lymph Node Circulation and Homing Mechanisms

      • Ann Ager, Mark C. Coles, Jens V. Stein

      Pages 75-94

7. Programmed and Nascent Gut-Associated Organized Lymphoid Tissues

   1. Front Matter

      Pages 95-95

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8. Programmed and nascent gut-associated organized lymphoid tissues

   1. Structure and Development of Peyer’s Patches in Humans and Mice

      • Tom Cupedo, Mark C. Coles, Henrique Veiga-Fernandes

      Pages 97-106

   2. Cryptopatches and Isolated Lymphoid Follicles: Aspects of Development, Homeostasis and Function

      • Heike Herbrand, Oliver Pabst

      Pages 107-117

9. Single Complexity: The Spleen

   1. Front Matter

      Pages 119-120

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10. Single complexity: the spleen

    1. Structural Evolution of the Spleen in Man and Mouse

       • Péter Balogh, Árpád Lábadi

       Pages 121-141

    2. Formation and Function of White Pulp Lymphocyte Rich Areas of Spleen

       • Peter J. L. Lane, Fiona M McConnell, David Withers

       Pages 143-157

11. Disassembling the Puzzle: Effect of Aging

    1. Front Matter

       Pages 159-159

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12. Disassembling the puzzle: effect of aging

    1. Age-Associated Decline in Peripheral Lymphoid Organ Functions

       • Rania M. El Sayed, John G. Tew, Andras K. Szakal

       Pages 161-174

13. Back Matter

    Pages 175-177

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The human immune system is a complex network of tissues and organs dispersed throughout the body. Immunology, as one of the most rapidly evolving fields in bio¬medical research, has to date covered the essential cellular and molecular events neces¬sary for immune responses to occur. However, it has paid relatively little attention to important developmental processes underlying the formation of the tissues themselves that carry out immune responses in humans and other mammalians. In contrast to the thymus and bone marrow that are the sole tissues for generating mature leukocytes for antigen recognition and han¬dling in humans and most mammalian species, the peripheral lymphoid tissues where adaptive immune responses are focused display broad tissue distribution and possess diverse archi¬tectural characteristics. These organs develop prior to the individual’s exposure to external antigens, and despite their similar functions, their varied appearances indicate a substantial complexity of tissue ontogeny. This volume presents a comprehensive overview of the developmental features of the major peripheral lymphoid organs, thus examining the connection between immunological functionality and structural characteristics utilizing a developmental approach, for an audience ranging from undergraduate students to senior researchers in immunology, histology and clinical medicine.

• Histology
• Immunology
• Lymphoid Organs
• Lymphoid Tissues
• Spleen development

• , Department of Immunology and Biotechnolo, University of Pecs, Pecs, Hungary

  Peter Balogh

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