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Pharmacology of Mitochondria

  • Book
  • © 2017

Overview

Editors:
  1. Harpreet Singh

    1. Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Shey-Shing Sheu

    1. Department of Medicine, Thomas Jefferson University, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First book in the HEP series on pharmacology of mitochondria, in which vast number of current topics pertaining to mitochondria will be presented
  • Unique methods to study mitochondria are covered, such as super resolution microscopy, nano particles, proteomics, calcium and ROS measurements
  • Drug development specifically to mitochondria will be extensively discussed
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 240)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism

    • Naresh Babu V. Sepuri, Prasad Tammineni, Fareed Mohammed, Arunkumar Paripati
    Pages 3-20

  3. The Mitochondrial Permeability Transition Pore and ATP Synthase

    • Gisela Beutner, Kambiz N. Alavian, Elizabeth A. Jonas, George A. Porter Jr
    Pages 21-46

  4. The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer

    • Ildikò Szabò, Luigi Leanza
    Pages 47-69

  5. Anion Channels of Mitochondria

    • Devasena Ponnalagu, Harpreet Singh
    Pages 71-101

  6. Guide to the Pharmacology of Mitochondrial Potassium Channels

    • BartÅ‚omiej Augustynek, Wolfram S. Kunz, Adam Szewczyk
    Pages 103-127

  7. The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology

    • Jyotsna Mishra, Bong Sook Jhun, Stephen Hurst, Jin O-Uchi, György Csordás, Shey-Shing Sheu
    Pages 129-156

  8. Mitochondrial Fission in Human Diseases

    • Madhavika N. Serasinghe, Jerry E. Chipuk
    Pages 159-188

  9. Mitochondrial Cholesterol and the Paradox in Cell Death

    • Carmen García-Ruiz, Vicente Ribas, Anna Baulies, Jose C. Fernández-Checa
    Pages 189-210

  10. Mitochondrial Changes in Cancer

    • Shubha Gururaja Rao
    Pages 211-227

  11. The Emerging Role of Mitochondrial Targeting in Kidney Disease

    • Alfonso Eirin, Amir Lerman, Lilach O. Lerman
    Pages 229-250

  12. Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases

    • Sang-Bing Ong, Derek J. Hausenloy
    Pages 251-279

  13. Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!

    • Susana M. Cardoso, Sónia C. Correia, Cristina Carvalho, Paula I. Moreira
    Pages 281-308

  14. Leber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways

    • Rui Bi, Ian Logan, Yong-Gang Yao
    Pages 309-336

  15. Leber Hereditary Optic Neuropathy: Exemplar of an mtDNA Disease

    • Douglas C. Wallace, Marie T. Lott
    Pages 339-376

  16. Equipping Physiologists with an Informatics Tool Chest: Toward an Integerated Mitochondrial Phenome

    • Anders Olav Garlid, Jennifer S. Polson, Keith D. Garlid, Henning Hermjakob, Peipei Ping
    Pages 377-401

  17. Mitochondrial Flashes: Elemental Signaling Events in Eukaryotic Cells

    • Gaomin Feng, Beibei Liu, Tingting Hou, Xianhua Wang, Heping Cheng
    Pages 403-422

  18. Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and Mitocans

    • Diana Guzman-Villanueva, Volkmar Weissig
    Pages 423-438

  19. Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

    • Hiroko P. Indo, Clare L. Hawkins, Ikuo Nakanishi, Ken-ichiro Matsumoto, Hirofumi Matsui, Shigeaki Suenaga et al.
    Pages 439-456

  20. MITO-Porter for Mitochondrial Delivery and Mitochondrial Functional Analysis

    • Yuma Yamada, Hideyoshi Harashima
    Pages 457-472
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Keywords

About this book

This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

Editors and Affiliations

  • Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, USA

    Harpreet Singh

  • Department of Medicine, Thomas Jefferson University, Philadelphia, USA

    Shey-Shing Sheu

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