The Immune Response to Implanted Materials and Devices

1. Front Matter

   Pages i-xviii

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2. Host Response to Implanted Materials and Devices: An Overview

   • Michelle E. Scarritt, Ricardo Londono, Stephen F. Badylak

   Pages 1-14

3. Implications of the Acute and Chronic Inflammatory Response and the Foreign Body Reaction to the Immune Response of Implanted Biomaterials

   • James M. Anderson, Sirui Jiang

   Pages 15-36

4. Macrophages: The Bad, the Ugly, and the Good in the Inflammatory Response to Biomaterials

   • Marta Scatena, Karen V. Eaton, Melissa F. Jackson, Susan A. Lund, Cecilia M. Giachelli

   Pages 37-62

5. Understanding Nanoparticle Immunotoxicity to Develop Safe Medical Devices

   • Marina A. Dobrovolskaia

   Pages 63-80

6. Host Response to Synthetic Versus Natural Biomaterials

   • Kishor Sarkar, Yingfei Xue, Shilpa Sant

   Pages 81-105

7. Convergence of Osteoimmunology and Immunomodulation for the Development and Assessment of Bone Biomaterials

   • Zetao Chen, Chengtie Wu, Yin Xiao

   Pages 107-124

8. Modulation of Innate Immune Cells to Create Transplant Tolerance

   • Yue Zhao, Peixiang Lan, Xian C. Li

   Pages 125-150

9. Inflammatory Cytokine Response to Titanium Surface Chemistry and Topography

   • Stephen M. Hamlet, Saso Ivanovski

   Pages 151-167

10. The Biomechanical Environment and Impact on Tissue Fibrosis

    • Wayne Carver, Amanda M. Esch, Vennece Fowlkes, Edie C. Goldsmith

    Pages 169-188

11. Advancing Islet Transplantation: From Donor to Engraftment

    • Omaima M. Sabek

    Pages 189-211

12. Targeted Modulation of Macrophage Functionality by Nanotheranostics in Inflammatory Liver Disease and Cancer

    • Matthias Bartneck, Frank Tacke

    Pages 213-222

13. T-Cell Mediated Immunomodulation and Transplant Optimization

    • Sandra Grass, Sara Khalid Al-Ageel, Martin Hildebrandt

    Pages 223-235

14. Back Matter

    Pages 237-241

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This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

• Biomimicry at the cellular-material interface
• Functional tissue restoration
• Host response to implant
• Immune evasion
• Immuno-modulation
• Innate and acquired immunity
• Synthetic vs natural biomaterials

• Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy

  Bruna Corradetti

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