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Chromosomal Instability in Cancer Cells

  • Book
  • © 2015

Overview

Editors:
  1. B. Michael Ghadimi

    1. Visceral and Pediatric Surgery, Department of General, Göttingen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Thomas Ried

    1. Center for Cancer Research, National Cancer Institute, Bethesda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Reviews up-to-date knowledge of chromosomal instability in cancer
  • Examines strategies to harness this information for the better treatment of cancer patients
  • Written by acknowledged experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 200)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. DNA Repair and Chromosomal Translocations

    • Stefan K. Bohlander, Purvi M. Kakadia
    Pages 1-37

  3. CINcere Modelling: What Have Mouse Models for Chromosome Instability Taught Us?

    • Judith E. Simon, Bjorn Bakker, Floris Foijer
    Pages 39-60

  4. Telomere Dysfunction, Chromosomal Instability and Cancer

    • Jitendra Meena, K. Lenhard Rudolph, Cagatay Günes
    Pages 61-79

  5. Genetic Instability and Disease Prognostication

    • Timo Gemoll, Gert Auer, Thomas Ried, Jens K. Habermann
    Pages 81-94

  6. Causes of Chromosomal Instability

    • Holger Bastians
    Pages 95-113

  7. Patterns of Chromosomal Aberrations in Solid Tumors

    • Marian Grade, Michael J. Difilippantonio, Jordi Camps
    Pages 115-142

  8. Yeast as Models of Mitotic Fidelity

    • Eduardo Torres
    Pages 143-164

  9. The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development

    • Mirjam S. de Pagter, Wigard P. Kloosterman
    Pages 165-193

  10. Consequences of Aneuploidy in Cancer: Transcriptome and Beyond

    • Milena Dürrbaum, Zuzana Storchová
    Pages 195-224
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Keywords

About this book

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Editors and Affiliations

  • Visceral and Pediatric Surgery, Department of General, Göttingen, Germany

    B. Michael Ghadimi

  • Center for Cancer Research, National Cancer Institute, Bethesda, USA

    Thomas Ried

Bibliographic Information

  • Book Title: Chromosomal Instability in Cancer Cells

  • Editors: B. Michael Ghadimi, Thomas Ried

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-319-20291-4

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-20290-7Published: 25 September 2015

  • Softcover ISBN: 978-3-319-34962-6Published: 22 October 2016

  • eBook ISBN: 978-3-319-20291-4Published: 16 September 2015

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: VII, 224

  • Number of Illustrations: 39 illustrations in colour

  • Topics: Oncology, Cancer Research, Human Genetics

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